2001
DOI: 10.1164/ajrccm.164.6.2008010
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Effectiveness of Continuous Positive Airway Pressure in Mild Sleep Apnea–Hypopnea Syndrome

Abstract: The aim of this trial was to evaluate the effectiveness of continuous positive airway pressure (CPAP) in patients with mild sleep apnea- hypopnea syndrome (SAHS). One hundred forty-two consecutive patients with mild SAHS (apnea-hypopnea index 10-30, without severe sleepiness) were randomly assigned to receive conservative treatment (CT)-sleep hygiene and weight loss-(65 patients) or CT plus CPAP (77 patients), and 125 patients (86% males, age: 54 +/- 9 yr, BMI: 29 +/- 4 kg/m(2), AHI: 20 +/- 6, ESS: 12 +/- 4) c… Show more

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Cited by 230 publications
(169 citation statements)
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“…This discrepancy may be explained by the observation that nocturnal blood pressure measurements with automatic inflation devices produce electroencephalic evidence of arousals from sleep, and probably underestimate the true reduction in blood pressure during sleep [45]. Interestingly, therapeutic CPAP did not significantly lower office blood pressure when compared to subtherapeutic CPAP in current study, a finding similar to that of MONASTERIO et al [46], who did not observe a reduction in office blood pressure after 6 weeks of CPAP in patients with mild OSAS. These findings are likely to be due to difficulties in detecting small changes in blood pressure with the less reproducible office measurements [47], often ascribed to variable ''white coat'' effects [47].…”
Section: Blood Pressure Measurementssupporting
confidence: 67%
“…This discrepancy may be explained by the observation that nocturnal blood pressure measurements with automatic inflation devices produce electroencephalic evidence of arousals from sleep, and probably underestimate the true reduction in blood pressure during sleep [45]. Interestingly, therapeutic CPAP did not significantly lower office blood pressure when compared to subtherapeutic CPAP in current study, a finding similar to that of MONASTERIO et al [46], who did not observe a reduction in office blood pressure after 6 weeks of CPAP in patients with mild OSAS. These findings are likely to be due to difficulties in detecting small changes in blood pressure with the less reproducible office measurements [47], often ascribed to variable ''white coat'' effects [47].…”
Section: Blood Pressure Measurementssupporting
confidence: 67%
“…In mild to moderate disease, CPAP ameliorated only nighttime symptoms (e.g. snoring) in all studies (91)(92)(93)(94)(95), whereas in most studies subjective sleepiness did not change (92,94,95).…”
Section: Sleep Apnea and Continuous Positive Airway Pressure (Cpap) Tmentioning
confidence: 81%
“…These studies employed both generic measures such as the SF 36, which assesses physical functioning, mental health, role functioning, social functioning, pain, vitality, and mobility, and disease specific measures, commonly the Functional Outcomes of Sleep Questionnaire that examines the impact of daytime sleepiness on general productivity, activity level, vigilance, social outcome, and intimate and sexual relationships, to operationally define functional status and quality of life. These studies were inconsistent in their results as to whether CPAP enhances daily functioning better than conservative measures, (26,37,41) (35) A recent study of the effect of CPAP treatment on blood pressure in non-sleepy patients, defined as an ESS < 10, whose sample included older individuals, failed to observe an effect of active treatment on blood pressure compared to sham-CPAP. (43) Previously demonstrating that CPAP positively affected blood pressure in a sample that included sleepy participants,(35) the investigators suggested that the impact of CPAP on this outcome may be mechanistically related to daytime sleepiness.…”
Section: Functional Status and Quality Of Lifementioning
confidence: 99%