Effectiveness of contrast-enhanced ultrasound for the diagnosis of acute pancreatitis: A systematic review and meta-analysis

Yang, Fei; Li, Weiqin

doi:10.1016/j.dld.2017.03.017

Cited by 6 publications

(4 citation statements)

References 22 publications

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“…Another study demonstrated 91.0% sensitivity & 83.0% specificity of ultrasonography in diagnosis of patients with acute pancreatitis. 8 In research done by Tenner et al a total of 110 patients with acute pancreatitis were included. The likelihood of a positive ultrasonography result in a patient with acute pancreatitis that was clinically significant was 89.60% (sensitivity).…”

Section: Discussionmentioning

confidence: 99%

Study of Ct Scan Versus Ultrasonography in Diagnosis of Acute Pancreatitis

2024

jcdr

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Background: A pancreatic inflammation with a high morbidity and mortality rate is known as pancreatitis. Acute pancreatitis can be categorized into mild acute pancreatitis (MAP) and severe acute pancreatitis (SAP). Ultrasonography gives an early radiological evaluation of the organ, a hint as to the degree of involvement, and a chance to scan adjacent abdominal organs. An organ's crosssectional morphology, internal structure, focal or diffuse involvement, and involvement of nearby structures are all provided by a CT scan. Understanding the roles and difference in diagnosis of CT and USG in pancreatitis was the main goal, as was highlighting and assessing the instances in which USG was unable to diagnose cases that CT helped to resolve. Aim and Objectives:To assess and compare the diagnostic accuracy of USG and CT scan in pancreatitis patients hospitalized in our tertiary care hospital in India. Materials and Methods:It was a cross-sectional study at the Department of Radiology in our tertiary care hospital. The study included 78 patients, both male and female, aged 15-55, with an illness duration of less than two weeks. Individuals with quick onset stomach discomfort, temperature (>101F), tachycardia (heart rate >120/min), and serum amylase > 400U/L were considered positive indicators of acute pancreatitis and were included in this study. The study excluded patients with a history of abdominal injuries, hypersensitivity to iodinated contrast agents in the past, chronic renal failure, claustrophobic patients, and patients unable to undergo CT scanning.Result And Discussion: In 35 patients (44.87%), ultrasonography confirmed the diagnosis of acute pancreatitis. Acute pancreatitis was verified by CT in 40 (51.28%) of the patients. There were 30 true positives and 5 false positives among the USG-positive patients. Of the 43 patients who did not receive a positive USG, 5 were false negatives and 38 were true negatives (p=0.0001). When using computed tomography as the gold standard to diagnose acute pancreatitis, the overall sensitivity,

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Section: Discussionmentioning

confidence: 99%

Study of Ct Scan Versus Ultrasonography in Diagnosis of Acute Pancreatitis

2024

jcdr

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“…The clinical challenge is the early identification of the 20% of patients for whom AP will become severe in a matter of days (Afghani et al, 2015). Usually, the clinical signs of acute pancreatitis are non-specific, with serum amylase and lipase levels correlating poorly with disease severity (Fei and Li, 2017). The severe form of the disease is accompanied by serious complications and is reported to have a high mortality rate (Frossard et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

“…The mortality rate of AP, especially the clinically severe form (SAP), can be as high as 15-48.4% (Dellinger et al, 2012). Imaging is recommended to confirm the clinical diagnosis, evaluate the cause of the abdominal pain, and grade the extent and severity of acute pancreatitis (Fei and Li, 2017). There are many etiological factors such as trypsin autodigestion, pancreatic microcirculation malfunction, calcium overload in pancreatic acinar cells, oxygen-free radical injury, and cytokine injury involved in the pathogenesis of severe forms of acute pancreatitis (Frossard et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

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The Concept of AI-Based Algorithm: Analysis of CEUS Images and HSPs for Identification of Early Parenchymal Changes in Severe Acute Pancreatitis

Kielaite-Gulla¹,

Samuilis²,

Raišutis³

et al. 2021

Informatica

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1) Background: Identifying early pancreas parenchymal changes remains a challenging radiologic diagnostic task. In this study, we hypothesized that applying artificial intelligence (AI) to contrast-enhanced ultrasound (CEUS) along with measurement of Heat Shock Protein (HSP)-70 levels could improve detection of early pancreatic necrosis in acute pancreatitis. (2) Methods: Acute pancreatitis (n = 146) and age-and sex matched healthy controls (n = 50) were enrolled in the study. The severity of acute pancreatitis was determined according to the revised Atlanta classification. The selected severe acute pancreatitis (AP) patient and an age/sex-matched healthy control were analysed for the algorithm initiation. Peripheral blood samples from the pancreatitis patient were collected on admission and HSP-70 levels were measured using ELISA. A CEUS device acquired multiple mechanical index contrast-specific mode images. Manual contour selection of the two-dimensional (2D) spatial region of interest (ROI) followed by calculations of the set of quantitative parameters. Image processing calculations and extraction of quantitative parameters from the CEUS diagnostic images were performed using algorithms implemented in the MATLAB software. (3) Results: Serum HSP-70 levels were 100.246 ng/ml (mean 76.4 ng/ml) at the time of the acute pancreatitis diagnosis. The CEUS Peek value was higher (155.5) and the mean transit time was longer (40.1 s) for healthy pancreas than in parenchyma affected by necrosis (46.5 and 34.6 s, respectively). (4) Conclusions: The extracted quantitative parameters and HSP-70 biochem- * Corresponding authors.A. Kielaite-Gulla et al. ical changes are suitable to be used further for AI-based classification of pancreas pathology cases and automatic estimation of pancreatic necrosis in AP.

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