Effectiveness of CoQ10 Oral Supplements as an Adjunct to Scaling and Root Planing in Improving Periodontal Health

Manthena, Sathish

doi:10.7860/jcdr/2015/13486.6291

Cited by 19 publications

(36 citation statements)

References 16 publications

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“…10 Antioxidant therapy for treatment of periodontitis has given positive results as stated in a systemic review by Castro et al 11 CoQ10, which is also known as ubiquinone, because of its ubiquitous presence, is an antioxidant enzyme and has been studied widely for its effect in treatment of periodontal disease. [12][13][14][15][16][17][18][19][20] In the present study, an attempt had been made to evaluate the efficacy of CoQ10 in reduction of clinical parameters (GI, PI, PPD, and CAL) and its effect on SOD in GCF as an adjunct to Phase 1 periodontal therapy.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Evaluation of Efficacy of Coenzyme Q10 as an Adjunct to Nonsurgical Periodontal Therapy and Its Effect on Crevicular Superoxide Dismutase in Patients with Chronic Periodontitis

et al. 2020

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Objectives To assess the efficacy of coenzyme Q10 (CoQ10) as an adjunct to nonsurgical periodontal therapy and its effect on superoxide dismutase (SOD) in gingival crevicular fluid (GCF) in patients with chronic periodontitis (CP). Materials and Methods A total of 16 patients aged between 30 and 50 years having mild to moderate CP of both sexes having pocket depth of 5 to 7 mm in four nonadjacent interproximal sites were selected. The sites were randomized and divided into treatment and control groups. CoQ10 and a placebo gel were administered in the treatment and control sites, respectively, at baseline after scaling and root planing (SRP). GCF was collected using microcapillary method at baseline and 3 months and was assessed for SOD using enzyme-linked immunosorbent assay reader at 450 nm wavelength. Probing pocket depth, gingival index, and plaque index were assessed at baseline, 1 month, and 3 months, respectively. Statistical analysis For each assessment point, data were statistically analyzed using Student’s t-test and paired t-test. Level of significance was set at p < 0.05. Results On intergroup comparison, there was no statistically significant difference between the clinical parameters of both the groups at all the time intervals (p > 0.05), but there was a significant increase in the level of SOD in the test group (p > 0.05) compared with the control group at 3 months. Conclusions Adjunctive use of CoQ10 with SRP can boost the antioxidant concentration, but it is not superior to SRP in the treatment of CP.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Evaluation of Efficacy of Coenzyme Q10 as an Adjunct to Nonsurgical Periodontal Therapy and Its Effect on Crevicular Superoxide Dismutase in Patients with Chronic Periodontitis

et al. 2020

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“…The ubidecarenone is a coenzyme related to mitochondrial enzyme complexes and involved in oxidative phosphorylation in the production of ATP, which is sold as a dietary supplement and is not FDA approved as a drug, however, it is recommended to be used under discretion. For pharmacology, coenzyme Q10 was studied to use for treating of several diseases, e.g., Parkinson's [39], fibromyalgia [40,41], migraine [42,43], and periodontal disease [44,45]. DB00756 or Hexachlorophene is a bacteriostatic cleansing agent.…”

Section: Potential Targets Of Succinate Dehydrogenase Complexmentioning

confidence: 99%

Heterogeneous Network Model to Identify Potential Associations Between Plasmodium vivax and Human Proteins

Suratanee

Plaimas

2020

IJMS

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Integration of multiple sources and data levels provides a great insight into the complex associations between human and malaria systems. In this study, a meta-analysis framework was developed based on a heterogeneous network model for integrating human-malaria protein similarities, a human protein interaction network, and a Plasmodium vivax protein interaction network. An iterative network propagation was performed on the heterogeneous network until we obtained stabilized weights. The association scores were calculated for qualifying a novel potential human-malaria protein association. This method provided a better performance compared to random experiments. After that, the stabilized network was clustered into association modules. The potential association candidates were then thoroughly analyzed by statistical enrichment analysis with protein complexes and known drug targets. The most promising target proteins were the succinate dehydrogenase protein complex in the human citrate (TCA) cycle pathway and the nicotinic acetylcholine receptor in the human central nervous system. Promising associations and potential drug targets were also provided for further studies and designs in therapeutic approaches for malaria at a systematic level. In conclusion, this method is efficient to identify new human-malaria protein associations and can be generalized to infer other types of association studies to further advance biomedical science.

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“…[9,10,11] The recently conducted study also supported that CoQ10 supplementation along with scaling and root planing can prevent periodontitis by reducing gingival inflammation. [12] These findings suggest that there were significant clinical and microbiological benefits in supplementing nutritional supplement of CoQ10 with professional prophylaxis. …”

mentioning

confidence: 93%

CLINICAL SIGNIFICANCE OF CoQ10 IN PERIODONTAL HEALTH

Saini¹

2017

jemds

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Effectiveness of CoQ10 Oral Supplements as an Adjunct to Scaling and Root Planing in Improving Periodontal Health

Cited by 19 publications

References 16 publications

Evaluation of Efficacy of Coenzyme Q10 as an Adjunct to Nonsurgical Periodontal Therapy and Its Effect on Crevicular Superoxide Dismutase in Patients with Chronic Periodontitis

Evaluation of Efficacy of Coenzyme Q10 as an Adjunct to Nonsurgical Periodontal Therapy and Its Effect on Crevicular Superoxide Dismutase in Patients with Chronic Periodontitis

Heterogeneous Network Model to Identify Potential Associations Between Plasmodium vivax and Human Proteins

CLINICAL SIGNIFICANCE OF CoQ10 IN PERIODONTAL HEALTH

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