Effectiveness of Cork Fish Extract Gel on Fibroblast Proliferation in Socket Wound After Tooth Extraction

Abstract

Objective: Socket wound healing involves soft tissue cells that play an important role, namely fibroblasts. In the wound-healing process, proteins are needed that can accelerate wound healing, one of which is albumin. Cork fish contains the highest albumin than other fish. Albumin contains natural proteins and collagen that make up the extracellular matrix, which has the role of inducing growth factors, cell migration and adhesion, and tissue regeneration. The purpose of this study was to examine the effect of 1%, 3%, 5% and 7% cork fish extract gel on fibroblast cell proliferation in socket wound healing after tooth extraction. Methods: This study was a laboratory experimental study with 30 Wistar rats that were grouped into 5 groups. The treatment group was given cork fish extract gel, namely 1%, 3%, 5% and 7%, and the negative control group was only given base gel was then the tissue was tested using Hematoxylin Eosin to observe fibroblasts on the 3rd, 7th and 14th day. Results: Based on the results of the one-way ANOVA test, it showed that cork fish extract with a concentration of 1%, 3%, 5% and 7% has an effect on fibroblast proliferation in socket wound healing after tooth extraction. Conclusion: Based on the results of the one-way ANOVA test, it showed that 3% cork fish extract had an influence on fibroblast proliferation in healing socket wounds after tooth extraction.