Effectiveness of cyanoacrylate glue in the fixation of midline catheters and peripherally inserted central catheters in hospitalised adult patients: Randomised clinical trial (CIANO-ETI)

Padilla-Nula, Ferran; Bergua-Lorente, Alejandro; Farrero-Mena, Jordi; Escolà-Nogués, Anna; Llauradó-Mateu, Miriam; Serret-Nuevo, Carme; Bellon, Filip

doi:10.1177/20503121231170743

Cited by 6 publications

(6 citation statements)

References 38 publications

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“…In general, placement of catheters in vessels with low blood flow increases the risk of thrombosis; in both cases in our study group, catheter migration may have contributed to the thrombosis. Previous studies have shown that the use of CG was effective in reducing bleeding at the puncture site and controlling infection rather than immobilizing the catheter 14–16 . Our study using chest radiographs showed that the use of CG also inhibited catheter tip migration within the body.…”

Section: Discussionsupporting

confidence: 54%

“…Previous studies have shown that the use of CG was effective in reducing bleeding at the puncture site and controlling infection rather than immobilizing the catheter. [14][15][16] Our study using chest radiographs showed that the use of CG also inhibited catheter tip migration within the body. Because arrhythmias were not monitored, their incidence rate could not be evaluated.…”

Section: Catheter Tip Migration and Venous Thrombosismentioning

confidence: 82%

“…14,15 In addition, the effect of CG on catheter fixation has only been evaluated in studies using catheter length outside the body, and there have been no studies evaluating catheter tip position inside the body, which is supposed to affect the occurrence of complications. 16 In this study, we aimed to investigate the effect of CG on the suppression of catheter-related complications, such as catheter infection and thrombus formation, at the first institution in Japan to adopt CG for peripherally inserted central catheter (PICC) fixation in acutely ill adult patients. Moreover, we aimed to examine the effect of CG on the suppression of catheter tip migration inside the body using radiography.…”

Section: Introductionmentioning

confidence: 99%

“…However, although previous studies have shown that the use of CG is effective in controlling bleeding from the catheter insertion site and reducing infection, reports from Asia or Japan are lacking 14,15 . In addition, the effect of CG on catheter fixation has only been evaluated in studies using catheter length outside the body, and there have been no studies evaluating catheter tip position inside the body, which is supposed to affect the occurrence of complications 16 …”

Section: Introductionmentioning

confidence: 99%

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Peripherally inserted central catheter securement with cyanoacrylate glue and bloodstream infection: A retrospective cohort study

Kurata,

Ohira,

Hayano

et al. 2024

J Parenter Enteral Nutr

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BackgroundTreatment via a peripherally inserted central venous catheter is important for anticancer treatment, perioperative management, and nutritional management. In this study, we aimed to investigate the usefulness of cyanoacrylate glue (CG) in managing peripherally inserted central venous catheters in adults.MethodsThis retrospective cohort study enrolled 411 adults requiring a central venous catheter for treatment in the Chiba University Esophageal‐Gastro‐Intestinal Surgery department between January 2021 and October 2022. The preventive effect of CG in reducing adverse events, including infection, tip migration, and thrombus formation, was evaluated by reviewing electronic medical records, chest radiographs, and contrast‐enhanced computed tomography scans.ResultsCG and other dressings were used in 158 (CG group) and 253 (control group) patients, respectively. The incidence of catheter infection based on the clinical course was lower in the CG group (3.2%) than in the control group (9.1%; p=0.03). However, cases of infection confirmed by blood or catheter culture did not differ between the CG (1.3%) and control (1.9%) groups (p=1.0). Chest radiographs revealed that catheter tip migration was lesser in the CG group (8.2±6.7 mm) than in the control group (15.0±15.8 mm; p<0.01). There were two cases of venous thrombus formation in the control group.ConclusionIn a population dominated by esophago‐gastroenterological malignancy, peripherally inserted central catheter securement via CG was associated with decreased catheter removal due to suspected catheter infection. Further research on larger cohorts is needed to determine if other adverse events decrease following peripherally inserted central catheter securement via CG.This article is protected by copyright. All rights reserved.

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Section: Discussionsupporting

confidence: 54%

Section: Catheter Tip Migration and Venous Thrombosismentioning

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Peripherally inserted central catheter securement with cyanoacrylate glue and bloodstream infection: A retrospective cohort study

Kurata,

Ohira,

Hayano

et al. 2024

J Parenter Enteral Nutr

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“…In a sample of patients, Arista TM AH powder was applied at the site of anastomosis instead of glue, and a comparison of the two devices was carried out to test their stability and effectiveness at that site of action (Figure 3B). The procedure for stabilization and fixation of the PICCs (peripherally inserted central catheters) took place in the angiography room after identification by ultrasound of the endovascular access site and exclusion of in situ thrombosis [37,38] (Figure 4). If the identified site was affected by venous thrombosis, the other arm was used.…”

Section: Data Collections and Proceduresmentioning

confidence: 99%

Synthetic Hemostatic Sealants: Effectiveness, Safety and In Vivo Applications

Curcio,

Perri,

Piro

et al. 2023

Preprint

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Rapid haemostasis during surgery is essential when one wants to reduce the duration of opera-tions, reduce the need for transfusions, and above all when one wants to achieve better patient management. The use of haemostatic agents, sealants and adhesives improves the haemostatic process by offering several advantages, especially in vascular surgery. These agents vary widely in their mechanism of action, composition, ease of application, adhesion to wet or dry tissue, im-munogenicity and cost. The most used are cyanoacrylate-based glues (Glubran 2) or polysaccharide hydrogel-microsphere powder (AristaTMAH). This work is based on a retrospective study carried out on a sample of patients with different vascular diseases (FAV, pseudoaneurysm and PICC application) in which two different haemostatic sealants were used. The aim was to assess the safety, the advantages and the ability of both sealants to activate the haemostatic process at the affected site, also in relation to their chemical-physical characteristics. The obtained results showed that the application of Glubran 2 and AristaTMAH as surgical wound closure systems is effective and safe as the success achieved was ≥94% on anastomoses of FAV; 100% on stabilization of Picc catheters; ≤95% on pseudoaneurysms.

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Use of tissue adhesive for neonatal intravenous access devices: A scoping review

de Souza,

Takashima,

Silva

et al. 2024

Eur J Pediatr

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Neonates often require vascular access devices for medication or fluid therapy, but a third of devices fail before treatment completion or end with a complication. For adults and children, securing these devices with tissue adhesive (TA) increases the dwell and reduces complications. However, there is a lack of evidence for the neonatal population. This scoping review aimed to assess the evidence of TA for vascular access devices in neonates. The Arksey and O’Malley’s (2005) framework was used. The inclusion criteria covered studies published from 2007 (when TA was first reported for use in vascular access devices) to June 2024, available in English, Portuguese, and Spanish, across six databases. Two independent reviewers assessed the studies using Covidence software, with a third reviewer resolving conflicts. Quality assessment was performed using the Mixed Methods Appraisal Tool. From 981 identified studies, 12 were included. Most studies (n = 5, 41.7%) enrolled between 100 and 500 neonates with vascular access devices. Publications originated from four regions and were observational studies (n = 6, 50%), quasi-experimental (n = 3, 25%), and case series (n = 2, 16.7%) with one randomized controlled trial (8.3%) focusing on umbilical venous catheters (UVC). The most common TA composition used was a combination of n-butyl- and 2-octyl- cyanoacrylate (n = 4, 33.3%). The amount of TA applied varied across studies, and often TA was part of a bundle (n = 7, 58.3%). Most studies applied TA to central venous access devices (n = 10, 83.3%) and 2 (16.7%) in peripheral devices. Although there was variation in device failure, the studies generally indicated a reduction in complications such as dislodgment (central catheter: 11.3% [peripherally inserted central catheter {PICC}] to 24.6% [UVC] in non-TA group vs 0.7% [PICC] to 7.7% [UVC] in TA group), device-associated bloodstream infections (central: 7.7% [UVC] and incidence of 2.76/1000 catheter days [PICC] in non-TA group vs 3.1% [UVC] and incidence of 0.99/1000 catheter day [PICC] in TA group), and phlebitis (13% in non-TA group vs 3% in TA-group), as well as increased dwell time in peripheral catheters. Most studies included both term and preterm neonates but did not differentiate between them in their analyses. Skin assessment, life of first dressing, and follow-up of catheters and patients were not reported in most studies. Conclusion: TA may reduce complications in vascular access devices, but the evidence in neonates is limited and varied. Many studies include TA as part of bundle, making it difficult to isolate its effects. Additionally, the current evidence lacks robustness due to the design limitations of the studies. Future research should focus on randomized controlled trials to evaluate TA’s effectiveness and safety in preventing device failures and complications in neonates, considering different subgroups, to ensure the safety of TA in these nuanced populations. What is Known:• Research in adults and pediatrics provides evidence supporting the use of tissue adhesive (TA) for vascular access devices, showing a positive impact in reducing failures and complications.• The use of TA in neonates needs to be carefully considered due to their unique characteristics.What is New:• There is a gap in the literature on the use of TA for securing vascular access devices in neonates, particularly regarding its safety and effectiveness in preventing failures and complications.• Further studies are needed to provide robust evidence verifying the effectiveness and safety of TA in this population.

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Effectiveness of cyanoacrylate glue in the fixation of midline catheters and peripherally inserted central catheters in hospitalised adult patients: Randomised clinical trial (CIANO-ETI)

Cited by 6 publications

References 38 publications

Peripherally inserted central catheter securement with cyanoacrylate glue and bloodstream infection: A retrospective cohort study

Peripherally inserted central catheter securement with cyanoacrylate glue and bloodstream infection: A retrospective cohort study

Synthetic Hemostatic Sealants: Effectiveness, Safety and In Vivo Applications

Use of tissue adhesive for neonatal intravenous access devices: A scoping review

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