Effectiveness of Dichrostachys glomerata Spice Phenolics in Reduction of Oxidative Stress Associated with Obesity and Type 2 Diabetes; a Randomized, Double-Blind Placebo-Controlled Clinical Trial

Abstract

This work evaluated the effect of Dichrostachys glomerata on the improvement of antioxidant biomarkers in obesity and type 2 diabetes participants, in an eight-week randomized, double-blind, placebo-controlled design study. The active (400 mg) or placebo formulation were administered twice daily throughout the study period to two normoglycemic and two diabetic obese random groups. Plasma levels of a total of 8 biochemical parameters were taken at the baseline and after 4 and 8 weeks of treatment. No differences in urate variation were observed while the plasma phenolic content as well as the reduced glutathione level, ascorbate concentration, FRAP value and enzymatic antioxidant activities significantly increased with a concomitant reduction of MDA after 8 weeks compared to placebo (P < 0.01). On the contrary to urate and ascorbate, plasma polyphenol content correlated well with FRAP level in both treated groups indicating that phenolics from the spice greatly contributed to the antioxidant activity.

Oxidative Stress Modulation by Cameroonian Spice Extracts in HepG2 Cells: Involvement of Nrf2 and Improvement of Glucose Uptake

“…These processes ultimately appear to be significant in terms of counteracting the impairment of glucose uptake produced by oxidative stress, thereby restoring insulin sensitivity. In support of our results, the hypoglycemic activity of four of the spices studied here, Dichrostachys glomerata, Tetrapleura tetraptera, Xylopia aethiopica, and Aframomum melegueta, was reported by other studies conducted in animal models of diabetes and in clinical trials [39][40][41][42][43].…”

Effect of sieved fractionation on the physical, flow and hydration properties of Boscia senegalensis Lam., Dichostachys glomerata Forssk. and Hibiscus sabdariffa L. powders

“…Dry fruit pods are commonly used as spices in a traditional soup in Cameroon (Tchiegang and Mbougueng, 2005). Beneficial properties include antioxidant, anti-inflammatory, antihypertensive, anti-cancer and anti-diabetic effects (Fankam et al, 2011;Kuate et al, 2013). D. glomerata fruit powder has been used as supplement for enhancing growth performance of farmed chicken and producing chicken meat free from antibiotics residues (Kana et al, 2017).…”

The effects of DyglomeraⓇ (dichrostachys glomerata extract) on body fat percentage and body weight: a randomized, double-blind, placebo-controlled clinical trial

“…The results of in-vitro and in-vivo tests showed that this plant had antiviral, anti-infectious, anti-inflammatory and analgesic effects, inhibitory activity on low-density lipoproteins (LDL) oxidation, and improvement of obesity and type 2 diabetes [27,28,29,30,31,32,33]. In addition, the results of our research team's clinical trial on patients with metabolic diseases showed that the intake of DG extract greatly contributed to the improvement of antioxidant activity in the body and the improvement of cardiovascular risk factors [34,35]. In the previous clinical study to evaluate the efficacy of DG, it was confirmed that weight loss and fatty acid-related factors were decreased, however the change in body fat was not measured [34].…”