Effectiveness of dietary manipulation in the prevention of food allergy in infants

Zeiger, Robert S.; Heller, Susan; Mellon, Michael; O’Connor, Richard D.; Hamburger, Robert N.

doi:10.1016/0091-6749(86)90016-3

Cited by 99 publications

(44 citation statements)

References 75 publications

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“…Neonatal identification could lead to prevention regimens including exclusive breast-feeding and avoidance of smoking and domestic pets [1,4,9,14]. Next to a positive family history, cord blood IgE has been pre-…”

Section: Introductionmentioning

confidence: 98%

Cord serum IgE and early detection of the atopic phenotype: Suitable for routine screening?

Varonier

Assimacopoulos

1991

Eur J Pediatr

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Cord serum IgE has been shown to be a valuable marker for the prediction of atopy. Our study was designed to verify these findings for possible systematic screening recommendation. Our study consisted of 338 children who were followed from birth to 18 months. Cord serum IgE was measured by paper immunosorbent test and radioimmunoassay. All other data (sex, family history and environment, diet, occurrence of atopic manifestations) were recorded. Of the 338 children, 118 (34.9%) developed obvious clinical symptoms of atopy during the study period. Using the receiver operator curve we found an IgE level of 1.20 IU/ml to be the best cut-off point as a predictor of atopy with 95% specificity but 13% sensitivity. Combination with other predictors such as sex, family history, environmental factors and diet did not increase the predictive value of the test. Because of this low sensitivity we conclude that cord serum IgE is insufficient to detect individuals at risk for atopy even if associated with genetic and environmental factors. Thus it should not be recommended for routine screening purposes; more sensitive markers are needed.

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Section: Introductionmentioning

confidence: 98%

Cord serum IgE and early detection of the atopic phenotype: Suitable for routine screening?

Varonier

Assimacopoulos

1991

Eur J Pediatr

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“…The manifestation of atopic disease in genetically predisposed infants appears to depend on environ mental factors such as cigarette smoke, cooking with gas or the degreee of allergen exposure [1][2][3][4][5]. The eventual immunologic response to potential allergens also seems to be modulated by secretory antibodies and other immune factors from breast milk and by the infant's own production of IgA.…”

Section: Introductionmentioning

confidence: 99%

Elevated Concentrations of Salivary Secretory Immunoglobulin A Anti-Cow’s Milk Protein in Newborns at Risk of Allergy

Renz

Vestner

Petzoldt

et al. 1990

Int Arch Allergy Immunol

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Secretory immunoglobulin A (SIgA) anti-casein and SIgA anti-β-lactoglobulin (BLG) were determined in the saliva of 158 healthy mature infants at birth and in breast milk samples using a direct Elisa technique. IgG anti-casein and anti-BLG were measured in serum samples from mothers and newborns (cord blood). A high risk of allergy was defined in 66 infants who had cord blood (CB)-IgE levels ≥0.9 IU/ml and/or parents with atopic diseases. Thirty infants had CB levels <0.9 IU/ml and parents without clinical symptoms of atopy but with elevated serum IgE concentrations or type I skin reactions to common allergens (low risk). Sixty-two infants had CB-IgE levels <0.9 IU/ml and healthy parents (no risk). The groups were matched for social status, smoking and dietary habits. SIgA anti-casein and anti-BLG were detected in all newborns. SIgA anti-casein was significantly higher (p <0.05) in high risk infants (median 157; 50% confidence limits 45–270) than in no risk (48; 25–150) or low risk infants (43; 21–130). SIgA anti-casein values correlated with maternal allergy, maternal allergy plus CB-IgE, but not with paternal allergy. Breast milk SIgA anti-BLG was depressed (p <0.05) in mothers with manifest allergy compared to healthy mothers. Determination of salivary SIgA anti-casein may represent an additional screening method for early detection of infants with atopic disposition.

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“…These trials have had various designs and often limited followup and are thus difficult to compare. Multiple food avoidance during lactation and for the infant until age 1 appears to confer some benefit in infancy, with some groups reporting less of any atopic disorder in the first 2 years of life (28,(43)(44)(45)(46). Mostly, however, the followup stops at age 2 years, but in children followed up longer conflicting results emerge.…”

Section: Dietary Intervention -Avoidancementioning

confidence: 66%

Can we prevent allergy?

Gore

Čustović

2004

Allergy

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Allergic conditions continue to increase steeply. The last two decades have seen many prevention trials, studying the effect of dietary and environmental interventions. These trials have yielded invaluable information about the atopic march and also highlighted the need for a clear and commonly used nomenclature as well as a need for better outcome measures. This review discusses primary and secondary prevention studies and their results.

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Effectiveness of dietary manipulation in the prevention of food allergy in infants

Cited by 99 publications

References 75 publications

Cord serum IgE and early detection of the atopic phenotype: Suitable for routine screening?

Cord serum IgE and early detection of the atopic phenotype: Suitable for routine screening?

Elevated Concentrations of Salivary Secretory Immunoglobulin A Anti-Cow’s Milk Protein in Newborns at Risk of Allergy

Can we prevent allergy?

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