Effectiveness of different approaches to mass delivery of praziquantel among school-aged children in rural communities in Nigeria

Mafe, M A; Appelt, B; Adewale, Babatunde; Idowu, Emmanuel Taiwo; Akinwale, Olaoluwa P.; Adeneye, Adeniyi; Manafa, Ogenna; Sulyman, M; Akande, Oluwadamilola; Omotola, B.D.

doi:10.1016/j.actatropica.2004.11.004

Cited by 35 publications

(43 citation statements)

References 9 publications

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“…However, this did not guarantee increased school attendance. For instance, the use of communities, instead of schools, to distribute praziquantel for the control of schistosomiasis in Nigeria was recommended because of the low school attendance rate in many parts of the country (Mafe et al, 2005). In primary schools, praziquantel is distributed on a grade-wise basis and children swallow the tablets under the observation of the teachers.…”

Section: Discussionmentioning

confidence: 99%

Understanding Low Uptake of Mass Treatment for Intestinal Schistosomiasis Among School Children: A Qualitative Study in Jinja District, Uganda

et al. 2014

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SummaryDespite attempts to control intestinal schistosomiasis through school-based mass drug administration (MDA) with praziquantel using school teachers in Uganda, less than 30% of the school children take the treatment in some areas. The aim of the study was to understand why the uptake of praziquantel among school children is low and to suggest strategies for improved uptake. This was a cross-sectional qualitative study in which 24 focus group discussions and 15 key informant interviews were conducted 2 months after MDA. The focus group discussions were held with school children in twelve primary schools and the key informant interviews were held with school teachers, sub-county health assistants and the District Vector Control Officer. The study shows that the low uptake of praziquantel among school children is a result of a complex interplay between individual, interpersonal, institutional, community and public policy factors. The individual and interpersonal factors underpinning the low uptake include inadequate information about schistosomiasis prevention, beliefs and attitudes in the community about treatment of schistosomiasis and shared concerns among children and teachers about the side-effects of praziquantel, especially when the drug is taken on an empty stomach. The institutional, policy and community factors include inadequate preparation and facilitation of teachers and the school feeding policy, which requires parents to take responsibility for providing their children with food while at school, yet many parents cannot meet the cost of a daily meal due to the prevailing poverty in the area. It is concluded that strategies to improve uptake of praziquantel among school children need to be multi-pronged addressing not only the preparation and motivation of teachers and health education for children, but also the economic and political aspects of drug distribution, including the school feeding policy.

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Section: Discussionmentioning

confidence: 99%

Understanding Low Uptake of Mass Treatment for Intestinal Schistosomiasis Among School Children: A Qualitative Study in Jinja District, Uganda

et al. 2014

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“…It is pertinent to state however, that since the adoption of the WHA resolution, great progress has been made in a number of sub-Saharan African countries in the control of STH infections and schistosomiasis via mass chemotherapy among school children Adams et al, 2004;Mafe et al, 2005;King, 2006;Kihara et al, 2007;Adugna et al, 2007;Midzi et al, 2008). In many parts of sub-Saharan Africa there is currently a growing awareness of the public health significance of these helminth infections which previously were grossly neglected, and concerted advocacy for their control has resulted in increased political will and financial means to combat them (Keiser & Utzinger, 2008).…”

Section: Discussionmentioning

confidence: 99%

Soil transmitted helminth infections and schistosomiasis in school age children in sub-Saharan Africa: Efficacy of chemotherapeutic intervention since World Health Assembly Resolution 2001

Uneke

2010

Tanzania J Hlth Res

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Soil transmitted helminth infections (STH) and schistosomiasis constitute major public health challenges among school-age children in sub-Saharan Africa. This review assessed the efficacy of chemotherapeutic intervention in line with the World Health Assembly (WHA) resolution since the passage in 2001. Using the Medline Entrez-Pubmed search, relevant publications were identified via combinations of key words such as helminth infection, school children, chemotherapy, Africa. Albendazole, mebendazole, and praziquantel were the antihelminthic drugs most commonly evaluated. Cure rates >80% and egg reduction rates >90% were recorded in most cases of schistosomiasis using praziquantel. Albendazole was very effective against A. lumbricoides and hookworm infections with majority of the studies recording cure rates >75%, but the efficacy of the drug was poor against T. trichiura. To ensure the realization of the WHA resolution, there is need for regular treatment of school children, development of alternative antihelminthic drugs and vaccines, environmental control measures and health education. ______________________________________________________________________________________

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“…The benefit of this approach has been documented [18]–[20]. However, studies undertaken among school children have reported low uptake of praziquantel [21]–[23]. The fear of treatment and low school-attendance rates were highlighted as some of the major contributors to the low uptake.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of a Pre-treatment Snack on the Uptake of Mass Treatment for Schistosomiasis in Uganda: A Cluster Randomized Trial

et al. 2014

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Effectiveness of different approaches to mass delivery of praziquantel among school-aged children in rural communities in Nigeria

Cited by 35 publications

References 9 publications

Understanding Low Uptake of Mass Treatment for Intestinal Schistosomiasis Among School Children: A Qualitative Study in Jinja District, Uganda

Understanding Low Uptake of Mass Treatment for Intestinal Schistosomiasis Among School Children: A Qualitative Study in Jinja District, Uganda

Soil transmitted helminth infections and schistosomiasis in school age children in sub-Saharan Africa: Efficacy of chemotherapeutic intervention since World Health Assembly Resolution 2001

Effectiveness of a Pre-treatment Snack on the Uptake of Mass Treatment for Schistosomiasis in Uganda: A Cluster Randomized Trial

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