Effectiveness of Duloxetine for the Treatment of Chronic Nonorganic Orofacial Pain

Nagashima, Wataru; Kimura, Hiroyuki; Ito, Mikiko; Tokura, Tatsuya; Arao, Munetaka; Aleksić, Branko; Yoshida, Keizo; Kurita, K.; Ozaki, Norio

doi:10.1097/wnf.0b013e31827453fa

Cited by 60 publications

(50 citation statements)

References 26 publications

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“…Duloxetine is a selective serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor [40]. Duloxetine has been reported to be effective in diabetic neuropathic pain and recently in chronic orofacial pain disorders, such as burning mouth syndrome [41,42], suggesting other mechanisms of action. Indeed, duloxetine has been shown to act on certain sodium channels, blocking persistent late Nav1.7 currents.…”

Section: Discussionmentioning

confidence: 99%

SUNCT and SUNA: medical and surgical treatments

Lambru

Matharu

2013

Neurol Sci

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Short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) and short-lasting unilateral neuralgiform headache attacks with cranial autonomic symptoms (SUNA) are rare and often disabling primary headache disorders. Their management can be challenging. The abortive therapies are not generally useful as the attacks are relatively short lasting. A myriad of pharmacological preventive treatments have been tried in single case reports or small series in an openlabel fashion. Lamotrigine, as an oral preventive treatment, and lidocaine, as an intravenous transitional treatment, seem to be the most effective therapies. For medically intractable chronic forms of SUNCT and SUNA, several surgical approaches have been tried. These include ablative procedures involving the trigeminal nerve or the Gasserian ganglion, microvascular decompression of the trigeminal nerve, and neurostimulation techniques. This review provides an overview of the current pharmacological and surgical options for SUNCT and SUNA syndromes.

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Section: Discussionmentioning

confidence: 99%

SUNCT and SUNA: medical and surgical treatments

Lambru

Matharu

2013

Neurol Sci

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“…Thus, BMS/AO are relatively common conditions that are often treatment resistant, and new and effective therapeutics are urgently needed. We previously reported that the antidepressant, duloxetine, had some effect on chronic pain around the orofacial region (Nagashima et al, ) but that this effect was not related to its plasma concentration (Kobayashi et al, ).…”

Section: Introductionmentioning

confidence: 99%

Effect of antidepressant treatment on plasma levels of neuroinflammation‐associated molecules in patients with somatic symptom disorder with predominant pain around the orofacial region

Miyauchi

Tokura

Kimura

et al. 2019

Human Psychopharmacology

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Objective Burning mouth syndrome (BMS) and atypical odontalgia (AO) are examples of somatic symptom disorders with predominant pain around the orofacial region. Neuroinflammation is thought to play a role in the mechanisms, but few studies have been conducted. We aimed to better understand the role of neuroinflammation in the pathophysiology and treatment of BMS/AO. Methods Plasma levels of 28 neuroinflammation‐related molecules were determined in 44 controls and 48 BMS/AO patients both pretreatment and 12‐week post‐treatment with duloxetine. Results Baseline plasma levels of interleukin (IL)‐1β (p < .0001), IL‐1 receptor antagonist (p < .001), IL‐6 (p < .0001), macrophage inflammatory protein‐1β (p < .0001), and platelet‐derived growth factor‐bb (.04) were significantly higher in patients than in controls. Plasma levels of granulocyte macrophage colony stimulating factor were significantly higher in patients than in controls (p < .001) and decreased with treatment (.009). Plasma levels of eotaxin, monocyte chemoattractant protein‐1, and vascular endothelial growth factor decreased significantly with treatment (p < .001, .022, and .029, respectively). Conclusions Inflammatory mechanisms may be involved in the pathophysiology and/or treatment response of somatic symptom disorders with predominant pain around the orofacial region.

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“…Widely used chiral drugs, such as rosuvastatin, duloxetine and salbutamol, play an important role in treating human diseases 1,2,3 . In the environment of living systems, specific binding between molecules ( eg , enzymes, receptors, transporters, and DNA) is required for their medicinal effect.…”

Section: Introductionmentioning

confidence: 99%

Stereoselective binding of chiral drugs to plasma proteins

et al. 2013

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Chiral drugs show distinct biochemical and pharmacological behaviors in the human body. The binding of chiral drugs to plasma proteins usually exhibits stereoselectivity, which has a far-reaching influence on their pharmacological activities and pharmacokinetic profiles. In this review, the stereoselective binding of chiral drugs to human serum albumin (HSA), α1-acid glycoprotein (AGP) and lipoprotein, three most important proteins in human plasma, are detailed. Furthermore, the application of AGP variants and recombinant fragments of HSA for studying enantiomer binding properties is also discussed. Apart from the stereoselectivity of enantiomer-protein binding, enantiomer-enantiomer interactions that may induce allosteric effects are also described. Additionally, the techniques and methods used to determine drug-protein binding parameters are briefly reviewed.

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Effectiveness of Duloxetine for the Treatment of Chronic Nonorganic Orofacial Pain

Abstract: Duloxetine significantly relieved chronic nonorganic orofacial pain. Its pain-relieving effect appeared from 2 weeks of treatment. Furthermore, the pain-relieving effects of duloxetine similarly appeared regardless of the presence or absence of baseline depressive symptoms.

Cited by 60 publications

References 26 publications

SUNCT and SUNA: medical and surgical treatments

SUNCT and SUNA: medical and surgical treatments

Effect of antidepressant treatment on plasma levels of neuroinflammation‐associated molecules in patients with somatic symptom disorder with predominant pain around the orofacial region

Stereoselective binding of chiral drugs to plasma proteins

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