Effectiveness of dydrogesterone, 17-OH progesterone and micronized progesterone in prevention of preterm birth in women with a short cervix

Abstract

Combination management strategy including VP significantly benefits pregnancy outcomes in women with a short cervix compared with cerclage. Dydrogesterone, 17OHP, and OP were not found to be efficacious.

The value of oral micronized progesterone in the prevention of recurrent spontaneous preterm birth: a randomized controlled trial

“…published their 90‐patient study on the significant value of OMP in the tertiary prevention of preterm birth among patients who had successful tocolysis . Very recently, another study was published, unfortunately still with a very low number of cases. It assigned 10–15 cases only in each of the following four groups: dydrogesterone, OMP, vaginal progesterone and 17OHP‐C .…”

“…Very recently, another study was published, unfortunately still with a very low number of cases. It assigned 10–15 cases only in each of the following four groups: dydrogesterone, OMP, vaginal progesterone and 17OHP‐C . The patients started progesterone supplementation (400 mg/day) as late as 24 weeks in pregnancy and did not have any history of prior preterm delivery.…”

“…The scarcity of relevant research on the use of OMP to prevent SPD is further complicated by the variable doses used in the published studies, ranging between 100 mg 12‐hourly , 100 mg six‐hourly , 200 mg , and 400 mg once daily .…”

“…and Glover et al. . It reduces the risk of false‐positive results, since the rate of recurrent preterm birth may be as high as 22.5%, representing a 2.5‐fold increase in the risk of prematurity, as opposed to that among women with no previous SPD .…”

“…Exclusion criteria included established persistent uterine contractions, progesterone use in the current pregnancy (ongoing or past), active liver disease, obstetric, medical or surgical complications indicating delivery, presence of fetal anomalies incompatible with life, and preterm premature rupture of membranes (PPROM). We followed the example of some previous studies in allowing for cervical cerclage among our recruited cases . This, ethically, aimed to leave the women in the control group with some sort of protection against preterm delivery.…”