Prevention is a long-sought goal in psychiatry, and while primary prevention requires etiological knowledge we do not yet possess, secondary prevention, to minimize adverse illness effects, is a feasible objective. In the early 1990s, researchers identified long delays, averaging many years, between the onset of psychosis and the initiation of treatment (1) and found extended duration of untreated psychosis to be associated with more severe symptoms and poorer outcomes (2, 3). The effects were small in magnitude and did not affect quality of life, employment, or hospitalization (3), and researchers were clear that while prolonged duration of untreated psychosis was a possible cause of poor outcomes, prolonged untreated psychosis and poor outcomes might both be caused by other factors, such as lack of insight and/or motivation for treatment.