Effectiveness of growth hormone on growth and final height in paediatric chronic kidney disease

The success of growth hormone (GH) replacement in children with classical GH deficiency led to excitement that other causes of short stature may benefit similarly. However, clinical experience has shown less consistent and generally less dramatic effects on adult height, perhaps not surprising in light of increased understanding of GH and growth plate biology. Nonetheless, clinical demand for GH treatment continues to grow. Upon the 20th anniversary of the U.S. FDA’s approval of GH treatment for idiopathic short stature, this review will consider the factors underlying the expansion of GH treatment, the biological mechanisms of GH action, the non-GH deficient uses of GH as a height-promoting agent, biological constraints to GH action, and future directions.

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Effectiveness of growth hormone on growth and final height in paediatric chronic kidney disease

Cited by 3 publications

References 19 publications

Childhood growth hormone treatment: challenges, opportunities, and considerations

Childhood growth hormone treatment: challenges, opportunities, and considerations

Longitudinal Relationship Between Anemia and Statural Growth Impairment in Children and Adolescents With Nonglomerular CKD: Findings From the Chronic Kidney Disease in Children (CKiD) Study

Growth Hormone Treatment for Non-GHD Disorders: Excitement Tempered by Biology

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