Effectiveness of high-intensity interval training for weight loss in adults with obesity: a randomised controlled non-inferiority trial

D’Amuri, Andrea; Sanz, Jesús M.; Capatti, Eleonora; Vece, Francesca Di; Vaccari, Filippo; Lazzer, Stefano; Zuliani, Giovanni; Nora, Edoardo Dalla; Passaro, Angelina

doi:10.1136/bmjsem-2020-001021

Cited by 23 publications

(32 citation statements)

References 44 publications

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“…Similarly, a previous study found that a 12-week exercise intervention (3 × 90 min exercise session per week) had positive effects on cardiorespiratory fitness, muscular endurance, and body composition in overweight and obese adults [ 55 ]. In addition, another study showed that an exercise intervention using two modalities (continuous and interval training) induced weight loss, reduced BMI, and increased cardiorespiratory fitness in obese subjects [ 56 ]. The results could be explained by the fact that exercise training increases resting energy expenditure, lipid oxidation, and mitochondrial capacity [ 57 ].…”

Section: Discussionmentioning

confidence: 99%

Exercise Training Program Improves Subjective Sleep Quality and Physical Fitness in Severely Obese Bad Sleepers

Floody

Caamaño‐Navarrete

Chirosa

et al. 2022

IJERPH

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Background: Sleep quality is an important modulator of neuroendocrine function, as sleep problems are related to metabolic and endocrine alterations. Objective: The main objective was to determine the effects of an exercise training program on the sleep quality of severely obese patients with sleep problems. The secondary objective was to determine the relationship between fitness and anthropometric parameters with sleep quality scores. Methods: Thirty severely obese patients participated in 16 weeks of PA intervention (age: 39.30 ± 11.62 y, BMI: 42.75 ± 5.27 kg/m2). Subjective sleep quality, anthropometric parameters, and fitness (i.e., handgrip strength and cardiorespiratory fitness) were measured. Results: Two groups were defined as good sleepers (n = 15, 38.06 ± 12.26, men = 1) and bad sleepers (n = 15, 40.53 ± 11.23, men = 3). The good sleeper group reported improvement in cardiorespiratory fitness (61.33 ± 68.75 m vs. 635.33 ± 98.91 m, p = 0.003) and handgrip strength (29.63 ± 9.29 kg vs. 31.86 ± 7.17 kg, p = 0.049). The bad sleeper group improved their cardiorespiratory fitness (472.66 ± 99.7 m vs. 611.33 ± 148.75 m, p = 0.001). In terms of sleep quality dimensions, the bad sleeper group improved their subjective sleep quality (p < 0.001), sleep latency (p = 0.045), sleep duration (p = 0.031), and habitual sleep efficiency (p = 0.015). Comparing the changes in both groups (∆), there were differences in subjective sleep quality scores (∆ = 2.23 vs. ∆ = −3.90, p = 0.002), where 86.6% of the bad sleeper group improved sleep quality (p = 0.030). An increase in handgrip strength was correlated to improving sleep quality scores (r = −0.49, p = 0.050). Conclusions: Severely obese bad sleepers improved their subjective sleep quality, the components of sleep, and cardiorespiratory fitness through an exercise training program. Improvement in subjective sleep quality was linked to an increase in handgrip strength.

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Section: Discussionmentioning

confidence: 99%

Exercise Training Program Improves Subjective Sleep Quality and Physical Fitness in Severely Obese Bad Sleepers

Floody

Caamaño‐Navarrete

Chirosa

et al. 2022

IJERPH

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“…For this secondary analysis aimed at studying the biological response of irisin to long-term aerobic exercise, we used data that come from a randomized, single-blind, singlecentre, parallel-group, non-inferiority trial previously published that compares the efficacy of 12-weeks of HIIT and MICT in weight loss among obese (i.e., BMI between 30 and 55 kg/m 2 ) healthy adults (≤50 years). The study design and the main findings concerning the primary objective of the original study has been already published [25]. Briefly, the study was performed at the Exercise Physiology Laboratory of the University of Udine, Italy, between September 2017 and June 2018.…”

Section: Study Design and Populationmentioning

confidence: 99%

Biological Response of Irisin Induced by Different Types of Exercise in Obese Subjects: A Non-Inferiority Controlled Randomized Study

D’Amuri

Raparelli

Sanz

et al. 2022

Biology

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Background: Weight loss through physical exercise is warranted among obese individuals. Recently, a greater benefit in cardiorespiratory fitness was achievable with high-intensity interval training (HIIT) as compared with moderate intensity continuous training. The beneficial effect of training on CV health might be related to a specific modulation of circulating irisin, an adypo-myokine implicated in the regulation of energy expenditure. Methods: The present study investigates the circulating plasma levels of irisin at baseline and in response to 12-week of training program either with HIIT or moderate-intensity continuous training (MICT) among young female and male obese subjects. Clinical, anthropometric, and training characteristics for each participant were available. A sex-disaggregated data for circulating plasma levels of irisin pre- and post-training are provided as well as an adjusted multivariate linear regression model to identify the determinants of post-training irisin levels. Results: Data from a total of 32 obese healthy individuals (47% female, mean age 38.7 years, mean BMI 35.6 kg/m2), randomized in a 1:1 manner to HIIT or MICT were analyzed. Circulating plasma levels of irisin similarly and significantly decreased in both MICT and HIIT interventional groups. Females had higher post-exercise irisin levels than males (6.32 [5.51–6.75] vs. 4.97 [4.57–5.72] μg/mL, p = 0.001). When stratified by an interventional group, a statistically significant difference was observed only for the MICT group (male, 4.76 [4.20–5.45] μg/mL vs. female 6.48 [4.88–6.84] μg/mL p = 0.03). The circulating post-training level of irisin was independently associated with post-training fat-free mass (β −0.34, 95% confidence interval, CI −0.062, −0.006, p = 0.019) in a model adjusted confounders. When female sex was added into the adjusted model, it was retained as the only factor independently associated with irisin levels (β 1.22, 95% CI, 0.50, 1.93, p = 0.002). Conclusions: In obese healthy subjects, circulating irisin levels were reduced in response to 12-weeks of exercise involving either HIIT or MICT. A sex-specific differences in circulating irisin levels at baseline and as biological response to chronic exercise was described. Sex-specific biological response of irisin to exercise should be further explored to tailor sex-specific training approaches for improving the cardiovascular health of obese healthy subjects.

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“…the most studied form of exercise regime in obesity management [8]. However, MICT requires higher volume to induce a reduction In Body Weight (BW), therefore High Intensity Interval Training (HIIT) was introduced as a time saving alternative for weight control [9].…”

Section: Moderate Intensity Continuous Training (Mict) Ismentioning

confidence: 99%

Retrospective Comparison of Two Circuit Training Programs with Different Intensities in Obese and Overweight Individuals

Irene-Chrysovalanto¹,

Petros²,

Stefanakis³

2022

Int J Sports Exerc Med

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Aim:The aim of this study was to retrospectively compare two Circuit Training (CT) programs, one with moderate and one with high intensity, on the body composition, Cardiorespiratory Fitness (CRF), biochemical and physiological markers and isometric strength in apparently healthy obese and overweight individuals.Methods: This is a retrospective comparison of two groups of apparently healthy obese and overweight individuals that participated in two different trials examining the effect of two intermittent CT programs. The experimental groups in both trials were originally compared to a control (no exercise) group. One trial examined the effect of high intensity CT (HCT group) and the other the effect of moderate intensity CT (MCT group, n = 30). Participants on both trials were randomly assigned to the exercise or the control group. Both groups performed two exercise sessions per week for 8 weeks. MCT group performed 2 circuits of 8 exercise stations with 12 repetitions per station, performed for 1min at 50-60% of Heart Rate Reserve (HRR) alternated with 30s active recovery stations at 40-50% of HRR for the whole duration of the 8 weeks. HCT group performed 2 circuits of 6 exercise stations with 10-12 repetitions per station, performed for 1min at 50-60% of HRR alternated with 1min stations of 40-50% of HRR for the first 2 weeks and then progressed to an intensity of 70-85% of HRR, alternated with stations performed at 50-60% of HRR. Body composition, Cardiorespiratory Fitness (CRF), biochemical and physiological markers and isometric strength were measured in both groups using the same methodology.Results: Both programs had a 100% completion rate without any adverse effects. After 8 weeks, HCT group had greater but not significantly different reductions in body weight (BW) (HCT: -3.6%, MCT: -2.5%), body mass index (BMI) (HCT: -3.5%, MCT: -2.7%), in percentage (%) (HCT: -4.5%, MCT: -3.7%), and in kilograms (Kg) (HCT: -7.9%, MCT: -5.9%) of body fat, percentage (%) (HCT: 5%, MCT: 3.3%) and in kilograms (Kg) of lean body mass (LBM) (HCT: 1.9%, MCT: 0.3%), in waist circumference (WC) (HCT: -2.7%, MCT: -1.4%), in hip circumference (HCT: -1.3%, MCT: -0.5%), waist-hip ratio (WHR) (HCT: -1.2%, MCT: -1.1%), heart rate at rest (HR-rest) (HCT: -5%, MCT: -4.3%), mean arterial pressure (MAP) (HCT: -4.8%, MCT: -4.5%) and greater improvement in maximal oxygen uptake (HCT: 16.7%, MCT: 11.1%) (VO 2 peak). Blood lipids did not improve significantly in either group, but reductions in some variables were greater in the HCT group. On the other hand, MCT group appeared to induce greater improvements in Systolic Blood Pressure (SBP) (HCT: -3%, MCT: -5.3%), Diastolic Blood Pressure (DBP) (HCT: -4.6%, MCT: -5.6%), Double Product (RPP) (HCT: -7.2%, MCT: -10 %) and isometric strength of the lower extremity. Conclusion:Short duration CT programs with moderate intensity produce comparable changes in body weight, body composition and other health variables in obese and overweight individuals without comorbidities. This can possibly increase co...

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Effectiveness of high-intensity interval training for weight loss in adults with obesity: a randomised controlled non-inferiority trial

Cited by 23 publications

References 44 publications

Exercise Training Program Improves Subjective Sleep Quality and Physical Fitness in Severely Obese Bad Sleepers

Exercise Training Program Improves Subjective Sleep Quality and Physical Fitness in Severely Obese Bad Sleepers

Biological Response of Irisin Induced by Different Types of Exercise in Obese Subjects: A Non-Inferiority Controlled Randomized Study

Retrospective Comparison of Two Circuit Training Programs with Different Intensities in Obese and Overweight Individuals

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