Effectiveness of highly active antiretroviral therapy in Spanish cohorts of HIV seroconverters

Pérez‐Hoyos, S.; Amo, Julia del; Muga, Roberto; Romero, Jorge del; Olalla, Patricia García de; Guerrero, Rafael; Hernández-Aguado, Ildefonso

doi:10.1097/00002030-200302140-00009

Cited by 90 publications

(57 citation statements)

References 28 publications

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“…Finally, regarding the clinical and epidemiological aspects of the results, these correspond with a multicentric study on the e ectiveness of highly active antiretroviral treatment in Spain [23], where longer AIDS incubation periods were observed for women. There are several possible reasons for the observation that the longer an injecting drug user remains seronegative, the longer s/he remains AIDS-free once s/he is infected with HIV.…”

Section: Discussionsupporting

confidence: 73%

A parametric survival model with an interval‐censored covariate

Langohr

Gómez

Muga

2004

Statistics in Medicine

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We present a parametric survival model whose particularity consists in the inclusion of an interval-censored covariate. The methodology is motivated by a study on injecting drug users in Badalona (Spain), most of whom suffered HIV infection as a result of their drug addiction. The study aims to examine the possible association between the elapsed time from first injecting drug use until HIV infection and the subsequent AIDS incubation period. Whereas the moment of HIV infection cannot be observed exactly and is therefore interval-censored, time until AIDS onset is doubly-censored. For the maximization of the resulting likelihood function, we use a numerical solver. Maximization is carried out by means of the mathematical programming language AMPL.

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Section: Discussionsupporting

confidence: 73%

A parametric survival model with an interval‐censored covariate

Langohr

Gómez

Muga

2004

Statistics in Medicine

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“…Since the advent of ART, mortality rates for people living with HIV/AIDS have decreased substantially both in resourcerich 1,2 and resource-limited settings 3,8 with conflicting reports about gender-related differences in mortality [9][10][11][12][13][14][15][16] . Where differences have been reported, little is known about the reasons.…”

Section: Introductionmentioning

confidence: 99%

Gender differences in retention and survival on antiretroviral therapy of HIV-1 infected adults in Malawi

Taylor-Smith¹,

Tweya²,

Harries³

et al. 2010

Mal. Med. J

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BackgroundThere is currently a dearth of knowledge on gender differences in mortality among patients on ART in Africa. MethodsUsing data from the national ART monitoring and evaluation system, a survival analysis of all healthcare workers, teachers, and police/army personnel who accessed ART in Malawi by June, September and December 2006 respectively, was undertaken. Gender differences in survival were analysed using Kaplan-Meier estimates and rate ratios were derived from Poisson regression adjusting for confounding. Results 4670ART patients (49.8% female) were followed up for a median of 8.7 months after starting ART. Probability of death was significantly higher for men than women (p<0.001). Controlling for age, WHO clinical stage and occupation, men experienced nearly 2 times the mortality of women RR 1.90 [95% CI: 1.57-2.29]. A higher proportion of men initiated ART in WHO stage 4 (p<0.001). ConclusionAmong healthcare workers, teachers, police/army personnel, men have higher mortality on ART than women. Possible reasons are unclear but could be biological or because men present for ART at a later clinical stage or have poorer adherence to therapy. Improving early access to ART may reduce mortality, especially among men. A gender difference in adherence to therapy needs further investigation.

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“…1,2 Others have examined relative survival time following AIDS diagnosis, controlling for stage of disease. 3,4 Such approaches…”

Section: Introductionmentioning

confidence: 99%

Trends in Predictors of Death due to HIV-Related Causes Among Persons Living with AIDS in New York City: 1993-2001

Nash

Katyal

Shah

2005

Journal of Urban Health: Bulletin of the New York Academy of Me

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Effectiveness of highly active antiretroviral therapy in Spanish cohorts of HIV seroconverters

Abstract: Reductions in incidence of AIDS and death in GEMES are seen after 1998 and 1999, respectively, compared with 1992-1995, being more pronounced in MSM compared with IDU, the commonest category in Spain.

Cited by 90 publications

References 28 publications

A parametric survival model with an interval‐censored covariate

A parametric survival model with an interval‐censored covariate

Gender differences in retention and survival on antiretroviral therapy of HIV-1 infected adults in Malawi

Trends in Predictors of Death due to HIV-Related Causes Among Persons Living with AIDS in New York City: 1993-2001

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