Effectiveness of Hyaluronic Acid Gel and Intrauterine Devices in Prevention of Intrauterine Adhesions after Hysteroscopic Adhesiolysis in Infertile Women

Abstract

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Alternativas terapéuticas para el manejo del síndrome de Asherman

“…Cedars y Adeleye (2021) compararon el porcentaje de recurrencia entre las mujeres en las que se usó el ácido hialurónico con las que no se utilizó, se evidencia que la tasa disminuye al 14% en el primer grupo, sin embargo, no existen datos sobre la tasa de embarazo y nacidos vivos después de su uso. Otro estudio realizado por Trinh et al (2022) indica que el DIU en combinación con HA es más eficaz que él HA solo y en los casos donde aparecieron nuevas adherencias, estas en su mayoría eran leves.…”

“…El ácido hialurónico (HA) actúa uniéndose a un conjunto de moléculas de agua para lograr una mejor hidratación tisular y disminuir la formación de tejido fibrótico, incrementa la capacidad de resistencia de las células ante lesiones mecánicas, de esta manera, evitan la aparición de tejido de granulación y fibroso, además tiene propiedades como visco-elasticidad, plasticidad y permeabilidad, lo que contribuye a la prevención de adherencias postoperatorias (Trinh et al, 2022).…”

Cyclical endometrial repair and regeneration: Molecular mechanisms, diseases, and therapeutic interventions

“…Endometrial regeneration and menstruation were also better in patients with postoperative HA implants during long-term follow-up. 232 However, many studies have confirmed that simple physical barriers or drugs are ineffective in promoting endometrial repair and maintaining tissue homeostasis. After 5 years of followup, Thubert et al 233 found that HA could not restore the abnormally shed endometrium to a normal functional condition and could not interfere with the outcome of pregnancy.…”

Efficacy of electrical stimulation combined with ultrasound acupuncture therapy on treatment in patients with intrauterine adhesions: Study protocol for a placebo-controlled, single-blind, single-center, randomized trial

“…[ 7 ] The current report found that IUA was associated with decline in reproductive clinical outcomes after natural conception and assisted reproductive technologies. [ 8 ] The prevalence of IUAs is currently not entirely consistent, ranging from 0.3% (an incidental finding in women with intrauterine device placement without gynecological symptoms) to 21.5% (women with postpartum curettage). [ 9 ] Of all the tools used to diagnose IUA or evaluate the severity of IUA, hysteroscopy is the current gold.…”

“…[ 10 ] In the treatment, the recovery of uterine shape and function is mainly helped by surgical separation of the adherent uterine cavity, supplemented by physical isolation and hormone to promote endometrial regeneration. [ 8 ] Operative hysteroscopy is also considered a good treatment for patients. [ 11 ] The postoperative effectiveness of hysteroscopic separation of IUAs is generally satisfactory, and the probability of usual or improved menstruation after surgery can reach 92% to 96%.…”