Effectiveness of Hydrogen Rich Water on Antioxidant Status of Subjects with Potential Metabolic Syndrome—An Open Label Pilot Study

Nakao, Atsunori; Toyoda, Yoshiya; Sharma, Prachi; Evans, Malkanthi; Guthrie, Najla

doi:10.3164/jcbn.09-100

Cited by 277 publications

(230 citation statements)

References 28 publications

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“…It has been well established that hydrogen-rich water has beneficial effects on different disease models and is mostly dependent on its anti-inflammation, 48) and antioxidative properties. 49) Hydrogen molecules also rapidly diffuse into tissues and cells and it is mild enough to disturb cellular processes.…”

Section: Discussionmentioning

confidence: 99%

Anti-obesity Effect of Alkaline Reduced Water in High Fat-Fed Obese Mice

Ignacio

Kang

Kim

et al. 2013

Biological & Pharmaceutical Bulletin

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Whether or not alkaline reduced water (ARW) has a positive effect on obesity is unclear. This study aims to prove the positive effect of ARW in high-fat (HF) diet-induced obesity (DIO) in C57BL/6 mice model. Toward this, obesity was induced by feeding the C57BL/6 male mice with high-fat diet (w/w 45% fat) for 12 weeks. Thereafter, the animals were administered with either ARW or tap water. Next, the degree of adiposity and DIO-associated parameters were assessed: clinico-pathological parameters, biochemical measurements, histopathological analysis of liver, the expression of cholesterol metabolism-related genes in the liver, and serum levels of adipokine and cytokine. We found that ARW-fed mice significantly ameliorated adiposity: controlled body weight gain, reduced the accumulation of epididymal fats and decreased liver fats as compared to control mice. Accordingly, ARW coordinated the level of adiponectin and leptin. Further, mRNA expression of cytochrome P450 (CYP)7A1 was upregulated. In summary, our data shows that ARW intake inhibits the progression of HF-DIO in mice. This is the first note on anti-obesity effect of ARW, clinically implying the safer fluid remedy for obesity control.Key words alkaline reduced water; adiponectin; cytokine; adiposity; epididymal fat; cholesterol 7α-hydroxylase Obesity has reached global epidemic status. In developed and developing countries, obesity is reported to be the sixth most important risk factor contributing to the overall burden of chronic disease.1) Forty three million children, 82% of which from developing countries, are affected with obesity.2)The World Health Organization recently reported that there were more than 1 billion overweight adults worldwide, of whom 500 million were obese.3) Obesity poses a major public health issue as it is known to be positively associated with increased risk of certain chronic diseases such as cardiovascular disease, hypertension, type 2 diabetes and fatty liver. [3][4][5] Excessive intake of dietary fats influences the progression of obesity, 6) which is characterized by accumulation of body fats marked by abnormal increase in adipose tissue mass and liver fats (adiposity), dysregulated levels of adipokines, and imbalance between pro-and anti-inflammatory cytokine. 7-9)The complexity of these pathogenetic mechanisms of obesity poses a challenge to the development of effective therapy. In that context, there has been growing concern for the need of newer therapeutic strategies that directly deal with these mechanisms. Of several such candidates, we first introduced the alkaline reduced water (ARW) for obesity control in highfat (HF) diet-induced obesity (DIO) in mice model. ARW refers to electrolyzed water produced from minerals such as magnesium and calcium, which is characterized by supersaturated hydrogen, high pH, and a negative oxidation reduction potential. This hydrogen-rich functional water has been introduced as a feasible therapeutic strategy for health promotion and disease prevention. [10][11][12] Our previous studies ...

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Section: Discussionmentioning

confidence: 99%

Anti-obesity Effect of Alkaline Reduced Water in High Fat-Fed Obese Mice

Ignacio

Kang

Kim

et al. 2013

Biological & Pharmaceutical Bulletin

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“…The positive therapeutic effect is proved during the research for people who suffer from metabolic syndrome [11].…”

Section: Research Of Existing Solutions Of the Problemmentioning

confidence: 99%

Influence of redox potential of different water quality on the human blood

Matsiyevska

2017

TAPR

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“…A pilot study was undertaken at Pittsburgh University in collaboration with KGK Synergic London Ontario Canada in order to evaluate the effectiveness of this type of water on 20 subjects (10 men and 10 women) whose biological status (weight, blood sugar, lipemia and cholesterolemia) was conducive to developing metabolic syndrome [50]. The MSW was prepared with a magnesium stick (Dr. Suisosui Friendear, Tokyo, Japan) to obtain a concentration of 0.55-0.65 mM.…”

Section: Studies Of the Therapeutic Action Of Mswmentioning

confidence: 99%

Physico-Chemical, Biological and Therapeutic Characteristics of Electrolyzed Reduced Alkaline Water (ERAW)

Henry

Chambron

2013

Water

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Abstract:The consumption of alkaline reduced water produced by domestic electrolysis devices was approved in Japan in 1965 by the Ministry of Health, Labour and Welfare for the cure of gastro-intestinal disorders. Today, these devices are freely available in several countries and can be easily purchased without reserve. The commercial information included with the device recommends the consumption of 1-1.5 L of water per day, not only for gastro-intestinal disorders but also for numerous other illnesses such as diabetes, cancer, inflammation, etc. Academic research in Japan on this subject has been undergoing since 1990 only but has established that the active ingredient is dissolved dihydrogen that eliminates the free radical HO• in vivo. In addition, it was demonstrated that degradation of the electrodes during functioning of the device releases very reactive nanoparticles of platinum, the toxicity of which has not yet been clearly proven. This report recommends alerting health authorities of the uncontrolled availability of these devices used as health products, but which generate drug substances and should therefore be sold according to regulatory requirements.

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Effectiveness of Hydrogen Rich Water on Antioxidant Status of Subjects with Potential Metabolic Syndrome—An Open Label Pilot Study

Cited by 277 publications

References 28 publications

Anti-obesity Effect of Alkaline Reduced Water in High Fat-Fed Obese Mice

Anti-obesity Effect of Alkaline Reduced Water in High Fat-Fed Obese Mice

Influence of redox potential of different water quality on the human blood

Physico-Chemical, Biological and Therapeutic Characteristics of Electrolyzed Reduced Alkaline Water (ERAW)

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