Effectiveness of Identified Javanese Turmeric Ethanol Extract for the Inhibition of Biofilm Formation by Streptococcus Mutans and Porphyromonas Gingivalis

Abstract

Objective: To study the effectiveness of identified Javanese turmeric ethanol extract (IJTEE) against single and combined biofilm formation byStreptococcus mutans and Porphyromonas gingivalis.Methods: S. mutans ATCC 25175 and P. gingivalis ATCC 33277 were tested for the minimum inhibitory concentration (MIC) and minimum bactericidalconcentration (MBC) of IJTEE using microdilution technique. The inhibition of biofilm formation by IJTEE was analyzed using crystal violet assay.Results: MIC and MBC of IJTEE for S. mutans were 5% and 15%, respectively. MIC of IJTEE for the biofilm of S. mutans was 1% and for that ofP. gingivalis was 15%; the MIC of IJTEE for the combined biofilm was 0.5%.Conclusion: IJTEE was effective in inhibiting single and combined biofilm formation by S. mutans and P. gingivalis.

Curcuma Xanthorrhiza Roxb. An Indonesia Native Medicinal Plant with Potential Antioral Biofilm Effect

“…Our studies have shown that the effectiveness of C. xanthorrhiza ethanol extract against Gram-positive bacteria was superior compared with its effect against Gram-negative bacteria. In addition, the efficacy of C. xanthorrhiza extract and XNT against Gram-positive bacteria is comparable to CHX [48,49,52].…”

“…Medicinal plant's extract from Acacia arabica, Tamarix aphylla L., and Melia azadirachta L. showed evidence of reducing oral biofilm formation and cleaning the well-developed oral biofilm [45]. Medicinal plant from South East Asia, C. xanthorrhiza Roxb., has also been proven through several studies to have eradication and inhibition effects against oral bacteria and candida biofilm [23,[46][47][48][49][50][51][52][53].…”