Effectiveness of inulin-type on the iron bioavailability in anemic female rats fed bio-yogurt

Mohammed, Osama B.; Dyab, Noha; Kheadr, Ehab; Dabour, Nassra

doi:10.1039/d0ra08873k

Cited by 12 publications

(10 citation statements)

References 59 publications

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“…In another study in 2020, the researchers tried to determine the effects of iron fortified yogurt (supplemented with short chain fatty acids produced by prebiotics) on various blood parameters of anemic rats. The results of this study showed that not only the hemoglobin and hematocrit levels of anemic rats were improved after consumption of fortified yogurt, but also the Red blood cell count was significantly improved (Mohammed, Dyab, Kheadr, & Dabour, 2021).…”

Section: Discussionmentioning

confidence: 88%

Co‐administration of Inulin and Iron Fortificants improves Iron Deficiency Biomarkers in Female Sprague Dawley Rats

Ahmad

Farooq²,

Anees

et al. 2022

Food Science & Nutrition

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Micronutrient deficiencies affect approximately 2 billion people worldwide and iron deficiency anemia is one of them. The instant research was an attempt to determine the efficacy of co‐administration of two iron fortificants (NaFeEDTA and FeSO4) and inulin (a prebiotic) on serum iron, ferritin, transferrin, and total iron‐binding capacity in iron‐deficient female Sprague Dawley rats. For this research, rats were divided into ten groups, (two control and eight treatment groups). Treatment groups were made iron deficient by feeding them with triapine, an iron binder for two weeks. All treatment groups were fed with inulin at two different dosage levels along with iron fortificants. The study results showed that serum ferritin and serum iron levels significantly improved from initiation to termination of study. Also, mean values of total iron‐binding capacity and serum transferrin showed a steady decline over a period of three months indicating that iron stores were being improved. It was concluded that co‐administration of inulin and iron fortificants helped improve iron deficiency biomarkers in female Sprague Dawley rats.

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Section: Discussionmentioning

confidence: 88%

Co‐administration of Inulin and Iron Fortificants improves Iron Deficiency Biomarkers in Female Sprague Dawley Rats

Ahmad

Farooq²,

Anees

et al. 2022

Food Science & Nutrition

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“…The effect of inulin on iron absorption has also been investigated in animals. A study by Mohammed et al, showed that the addition of inulin to yogurt with Fe 2 (SO 4 ) 3 administered to rats increased the bioavailability of iron, and the greatest effect was observed in the case of long-chain inulin [ 48 ] ( Table 2 ). The effect of increased iron absorption in the intestine after inulin ingestion in rats was also shown by Freitas et al [ 49 ] ( Table 2 ).…”

Section: Prebiotics In Anemiamentioning

confidence: 99%

“…has been successfully tested for the production of folate-enriched fermented dairy products [ 67 ]. The addition of Lactobacillus acidophilus in food has been correlated with higher levels of vitamin B12 and folate serum (postbiotic) ( p < 0.05) and decreased anemia prevalence ( p < 0.01) [ 48 , 68 ].…”

Section: Metabolic Postbiotics In Anemiamentioning

confidence: 99%

Prebiotics, Probiotics, and Postbiotics in the Prevention and Treatment of Anemia

et al. 2022

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Iron deficiency anemia (IDA) is very common and affects approximately 1/3 of the world’s human population. There are strong research data that some probiotics, such as Lactobacillus acidophilus and Bifidobacterium longum improve iron absorption and influence the course of anemia. Furthermore, prebiotics, including galactooligosaccharides (GOS) and fructooligosaccharides (FOS), increase iron bioavailability and decrease its destructive effect on the intestinal microbiota. In addition, multiple postbiotics, which are probiotic metabolites, including vitamins, short-chain fatty acids (SCFA), and tryptophan, are involved in the regulation of intestinal absorption and may influence iron status in humans. This review presents the actual data from research studies on the influence of probiotics, prebiotics, and postbiotics on the prevention and therapy of IDA and the latest findings regarding their mechanisms of action. A comparison of the latest research data and theories regarding the role of pre-, post-, and probiotics and the mechanism of their action in anemias is also presented and discussed.

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“…[15][16][17] Previous animal studies showed that inulin or FOS enhanced iron absorption. [18][19][20][21][22] Furthermore, most studies on rat models indicate a 10% (w/w) supplementation of inulin or FOS could enhance mineral absorption. [23][24][25] Higher dose could repress feed intake, whereas below 10% could lead to compromised effect or no effect.…”

Section: Introductionmentioning

confidence: 99%

Prebiotic Oligosaccharides Enhance Iron Absorption Via Modulation of Protein Expression and Gut Microbiota in a Dose‐Response Manner in Iron‐Deficient Growing Rats

Chen

Wang

Pan

et al. 2022

Molecular Nutrition Food Res

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Scope: Iron deficiency anemia (IDA) in children is one of the most common nutrition-related health conditions worldwide. Prebiotic oligosaccharides, fructo-oligosaccharide (FOS) and galacto-oligosaccharides (GOS), have shown to affect iron absorption in anemic subjects, but the results in previous studies are inconsistent, thus the underlying mechanism and the effective dose of GOS in mitigating anemia remain unclear. Methods and Results: The present study aims to investigate the mechanism of how GOS/FOS affect iron absorption in an iron-deficient growing rat model from the perspectives of protein expression and gut microbiota, and determine the optimum dose of GOS. Iron-deficient models are established by providing young rats diet without iron addition for 14 days. Later, iron-deficient rats are provided with standard rat chows supplemented with 0%, 3%, 5%, 10% GOS, and 10% FOS for 21 days. The results show that ≥5% GOS supplementation in diet improves iron status and significantly impacts iron-binding/transport protein expression. Furthermore, a dose-dependent modulating effect of GOS on gut microbiota is determined. Conclusion: For the first time, the present study provides evidence that GOS supplementation induces a dose-response effect on iron absorption and gut microbiota in the established model, suggesting a positive role of GOS in ameliorating IDA in children.

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Effectiveness of inulin-type on the iron bioavailability in anemic female rats fed bio-yogurt

Abstract: It is well-documented that iron deficiency leads to anemia, which is the utmost critical problem of nutrition worldwide.

Cited by 12 publications

References 59 publications

Co‐administration of Inulin and Iron Fortificants improves Iron Deficiency Biomarkers in Female Sprague Dawley Rats

Co‐administration of Inulin and Iron Fortificants improves Iron Deficiency Biomarkers in Female Sprague Dawley Rats

Prebiotics, Probiotics, and Postbiotics in the Prevention and Treatment of Anemia

Prebiotic Oligosaccharides Enhance Iron Absorption Via Modulation of Protein Expression and Gut Microbiota in a Dose‐Response Manner in Iron‐Deficient Growing Rats

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