This study intended to establish an Attribute X Treatment interaction among anxiety, stress, and response mode to programmed instruction, A total of 144 subjects were randomly assigned either to a constructed response mode, with or without reinforcement, or to a reading condition. Stress instructions were used for half the sample. Multiple linear regression analysis indicated that the reinforced constructed response group achieved more (than the reading group) on technical, difficult material. A significant interaction among facilitating anxiety and other variables was interpreted in terms of achievement motivation. Debilitating anxiety interacted with stress on easy materials, but did not interact with other variables on complex, technical content. Implications of these results for anxiety research in similar settings are discussed.