Effectiveness of Lifestyle Interventions on Obstructive Sleep Apnea (OSA): Systematic Review and Meta-Analysis

Araghi, Marzieh; Chen, Yen-Fu; Jagielski, Alison; Choudhury, Sopna; Banerjee, Dev; Hussain, Shakir; Thomas, G. Neil; Taheri, Shahrad

doi:10.5665/sleep.3056

Cited by 180 publications

(169 citation statements)

References 53 publications

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“…26-31 This, in turn, may be strongly associated with future cardiovascular events, fatal arrhythmia and sudden cardiac death. 5,6,8,9,24,32,33 OSA is also a common sleep disorder associated with several adverse health outcomes, 34 and the sporadic night arousal characteristic of OSA is responsible for the nocturia. 35 In the present study, the severity of SDB correlated with the frequency of nocturnal urination; however, the mechanism of nocturia in patients with OSA has not been fully elucidated.…”

Section: Discussionmentioning

confidence: 99%

Nocturia in Patients With Sleep-Disordered Breathing and Cardiovascular Disease

Miyazaki

Kojima

Yamamuro

et al. 2015

Circ J

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Background: Sleep apnea is a common condition and a cardiovascular risk factor. Continuous positive airway pressure (CPAP) reduces cardiovascular events and sleep apnea-related symptoms, especially in patients with obstructive sleep apnea (OSA), who occasionally experience nocturia, a common problem in individuals of advanced age. Methods and Results:The present study was a prospective, observational study including 1,429 consecutive patients with cardiovascular disease (CVD). A questionnaire on nocturia was administered and nocturnal pulse oximetry was performed. Patients with moderate-to-severe sleep-disordered breathing (SDB) underwent polysomnography, and patients with OSA received CPAP therapy. Nocturia was observed in 561 of 666 patients included in the analysis. A multiple logistic regression analysis revealed that nocturia was associated with oxygen desaturation defined as a 3% decrease (P=0.0335) independent of age (P<0.0001), male sex (P=0.0078), hypertension (P=0.0139), and B-type natriuretic peptide (BNP) level (P=0.0185). Nocturia was reduced in patients who continued CPAP treatment and they also showed a decrease in the apnea-hypopnea index (45.3±13.6 vs. 2.5±3.7 events/h, P<0.0001), systolic blood pressure (121.6±11.9 vs. 113.4±8.8 mmHg, P=0.0002), and BNP level (57.7 [15.0-144.4] vs. 27.4 [8.5-111.7] pg/ml, P=0.0006).Conclusions: CPAP has the potential to reduce nocturia and risk factors for SDB such as increased blood pressure and BNP level, which may be beneficial in older men with CVD and OSA. (Circ J 2015; 79: 2632 -2640

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Section: Discussionmentioning

confidence: 99%

Nocturia in Patients With Sleep-Disordered Breathing and Cardiovascular Disease

Miyazaki

Kojima

Yamamuro

et al. 2015

Circ J

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“…Since, for the snoring symptoms, a 95% significant drop in prevalence was found for the RYGB group, with no change in the NS group, it is possible to speculate that the effects on blood pressure in the S group would be related to sleep apnea since by improving it using other types of treatment, hypertensive levels of blood pressure can decrease. 20 In the same context, in the Norwegian study of Hofsø et al, 4 76 patients underwent RYGB and 63 received an NST for intensive lifestyle modifications: clear benefits of RYGB on decreasing the BP of the SO patients were shown. Rossi et al 15 also showed a similar decrease of 68.1% in cases of hypertension after surgery.…”

Section: Discussionmentioning

confidence: 97%

Metabolic syndrome resolution by Roux-en-Y gastric bypass in a real world: a case control study

Schmid

Neto

Dias

et al. 2015

Rev. Assoc. Med. Bras.

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Metabolic syndroMe resolution by roux-en-y gastric bypass in a real world: a case control study rev assoC med bras 2015; 61 (2) Conflict of interest: noneObjectives: the aim of this study was to evaluate the efficacy of Roux-en-Y Gastric Bypass (RYGB), compared with nonsurgical treatment (NS group), as an instrument for inducing remission of co-morbidities related to Metabolic Syndrome (MetS) in patients with Obesity, grades 2 and 3 (Ob2,3). Methods: two hundred and fifty eight Ob2,3 patients were selected in a retrospective analysis and included in a case control study. MetS was defined as described by the International Diabetes Federation. One hundred and twenty-nine of these patients underwent RYGB (S group), and 129 were assessed as an NS group. Results: at baseline, S and NS groups did not differ in BMI, age, female sex and prevalence of MetS (p>0.05). For the S group the outcomes were a reduction in BMI of 38.1% (p<0.001), waist circumference of 28.6% (p<0.001), fasting plasma glucose of 10.5% (p<0.001), serum LDL-cholesterol of 21.9% (p<0.001) and of 85% in the number of patients with MetS (p<0.001). For the NS group, only a decrease of 4.12%(p=0.047) in triglyceride levels and of 5.9%(p=0.031) in Diastolic Blood Pressure was observed. In the NS group, 98.6% of the patients continued to have MetS. The number needed to treat (NNT) with surgery to resolve one case of MetS was 1.2 (CI 95%: 1.1 -1.4). Conclusion: in the real world, in the South of Brazil, compared with NS treatment and after 1 year of observation, RYGB is highly effective for decreasing the prevalence of MetS.

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“…This recommendation has been bolstered by findings from large-scale clinical trials that have demonstrated improvement of OSA with interventions that incorporate calorie restricted [6][7] , or very low calorie diets [8] . Furthermore, others have reported that the magnitude of reduction in apnea-hypopnea index (AHI), a measure of OSA severity, is associated with the degree of weight loss [9][10] .…”

Section: Weight Loss For Osa Treatmentmentioning

confidence: 99%

Focusing on Omega-3 Fatty Acids for Treatment of Obstructive Sleep Apnea and its Cardiovascular Complications

Papandreou

Patil

Dobrosielski

2016

Journal of Respiratory Research

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The aim of this review is to focus on the role of omega-3 fatty acids on OSA and associated CVD risk, as well as provide novel hypotheses on their functional impact. Obstructive sleep apnea (OSA) is associated with increased cardiovascular disease (CVD) morbidity and mortality and is highly prevalent in obesity. The American Academy of Sleep Medicine recommends dietary induced weight-loss as a behavioral treatment option for OSA. Since a complex, rather than linear, relationship exists between weight loss and OSA improvement, dietary intervention studies must focus not only on the direct effects of weight loss, but whether dietary-quality may also affect OSA severity, through potential improvements in neuromuscular function of the upper airway.

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Effectiveness of Lifestyle Interventions on Obstructive Sleep Apnea (OSA): Systematic Review and Meta-Analysis

Cited by 180 publications

References 53 publications

Nocturia in Patients With Sleep-Disordered Breathing and Cardiovascular Disease

Nocturia in Patients With Sleep-Disordered Breathing and Cardiovascular Disease

Metabolic syndrome resolution by Roux-en-Y gastric bypass in a real world: a case control study

Focusing on Omega-3 Fatty Acids for Treatment of Obstructive Sleep Apnea and its Cardiovascular Complications

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