Effectiveness of lingual versus labial fixed appliances in adults according to the Peer Assessment Rating index

Ata-Ali, Fadi; Plasencia, Eliseo; Lanuza-Garcia, Alicia; Ferrer-Molina, Marcela; Melo, María; Ata-Ali, Javier

doi:10.1016/j.ajodo.2018.07.018

Cited by 18 publications

(14 citation statements)

References 22 publications

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Section: Introductionmentioning

confidence: 99%

“…In common practice, orthodontic treatments utilize different kinds of orthodontic appliances [1][2][3]. The appliances are described in various types depending on the position in which they are applied for their function [2,4]. Many differential forces are exerted on the periodontal tissues by all forms of orthodontic appliances [2,5,6].…”

Section: Introductionmentioning

confidence: 99%

“…The appliances are described in various types depending on the position in which they are applied for their function [2,4]. Many differential forces are exerted on the periodontal tissues by all forms of orthodontic appliances [2,5,6]. Such mechanical stresses applied on the periodontium allow a wide range of growth factors, cytokines and chemokines to be secreted by the tissue [7,8].…”

Section: Introductionmentioning

confidence: 99%

“…Such mechanical stresses applied on the periodontium allow a wide range of growth factors, cytokines and chemokines to be secreted by the tissue [7,8]. It has been well known that the secretory proteins in the saliva play a significant indirect role in the induction and resorption of the bone tissue by endogenous signalling pathways, which is also associated in the remodelling of the periodontium complex essential for tooth movement along with periodontal tissues [2,3,8,9]. In order to discern the factors influencing bone formation during treatment, an approachable understanding of the interplay and modifications in the secretion of these proteins is of foremost relevance and the studies so far are seeking to understand the principal molecules and the complicated signal transduction pathways necessary for remodelling the periodontal bone tissues for efficacious orthodontic procedures [8,9].…”

Section: Introductionmentioning

confidence: 99%

“…A number of cytokines are concurrent and actively secreted in saliva due to orthodontic procedure with distinct appliances, which therefore attribute as molecular signals for bone regeneration and remodelling [3,6,10]. Linking the levels of salivary cytokines and defensins within different appliances used for orthodontic treatments has presented practical experience to pursue and continuously achieve greater novel engineered orthodontic appliances that take into account the health of periodontium and aesthetics as well, as there is increasing demand for this [2,[11][12][13]. We are taking this opportunity in this comparative evaluation to explore a wide range of secreted cytokines and defensins in the saliva as well as salivary cell marker analysis of the patients treated with two different orthodontic appliance modalities.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of salivary pro inflammatory cytokines profile level in patients treated with labial and lingual fixed orthodontic appliances

Baeshen

2021

PLoS ONE

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The secretions of certain cytokines, chemokines and growth factors are triggered by orthodontic appliances, which often affect the remodelling of periodontal tissues. Critical cumulative forces are applied by various types of orthodontic appliances to the periodontium. The secretion of such molecules is probably responsible, through molecular and cellular communications, for the optimal resorption of hard tissues in the periodontal setting, which therefore enables the coordination of multiple movements of tooth. This study assessed and compared a wide range of cytokines, cellular marker analysis and defensins present in the saliva samples of human subjected to orthodontic treatment with two different treatment modalities, i.e., conventional lingual and labial fixed orthodontic appliances. A total 40 samples of saliva were obtained, of which 20 were treated with traditional lingual appliances and 20 were treated with labial fixed appliances. After 21 days of treatment, all salivary samples were collected from the subjects. In order to analyse a broad range of soluble cytokine levels in saliva by flow cytometry, a bead-based immunoassay was performed. Cell surface markers were analysed by flow cytometry. Protein levels of saliva for defensins were quantified by ELISA. Non-significant differences were observed in the cytokine levels in the saliva except for the significant effects for CCL2, IL-17A and IL-6. Cellular markers CD45 and CD326 showed high percentage in conventional lingual samples. Defensin levels were found to be lower in conventional lingual patients. Subjects with conventional lingual appliances had significantly higher salivary protein levels of IL-1β, CCL2, IL17A, and IL-6, higher CD45+ and CD326+ cells and lower defensin levels than subjects with fixed labial appliances. The current study provided a clear basis for the development of innovative methods to aid in the improvement of various procedural treatments and orthodontic equipment of next generation.

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