1999
DOI: 10.1001/jama.282.2.137
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Effectiveness of Live, Attenuated Intranasal Influenza Virus Vaccine in Healthy, Working Adults

Abstract: Intranasal trivalent LAIV vaccine was safe and effective in healthy, working adults in a year in which a drifted influenza A virus predominated.

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Cited by 379 publications
(205 citation statements)
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“…It is possible that variations in study endpoint and population, and season‐to‐season variability may contribute to the conflicting results regarding the relative efficacy of LAIV and TIV in adults 14 , 19 , 28 . In the more robust pediatric data, there is evidence to suggest that LAIV efficacy does not decline with increasing age.…”
Section: Discussionmentioning
confidence: 99%
“…It is possible that variations in study endpoint and population, and season‐to‐season variability may contribute to the conflicting results regarding the relative efficacy of LAIV and TIV in adults 14 , 19 , 28 . In the more robust pediatric data, there is evidence to suggest that LAIV efficacy does not decline with increasing age.…”
Section: Discussionmentioning
confidence: 99%
“…Delivering 1,000-3,000 TCID 50 of Edmonston B vaccine by drops to 5-10 year old children has been reported to result in an immune response among 41% of vaccine recipients 18 whereas delivering 25,000-45,000 TCID 50 of Edmonston-Zagreb vaccine by nasal drops to 6-12 month old children resulted in a reported immune response among all vaccine recipients. 19 Nasal spray administration, an effective delivery method of live-attenuated influenza vaccine, 20 has not been adequately studied for measles vaccine administration. 9 Additionally, the importance of delivering live-attenuated measles vaccine to the lung as opposed to nasal or bronchoalveolar lymphoid tissue is not known.…”
Section: Discussionmentioning
confidence: 99%
“…Although live attenuated vaccines (LAIVs) can induce of both humoral and cellular immunogenicity, in adults these vaccines have previously been associated with lower seroconversion rates and higher rates of laboratory-confirmed influenza when compared to trivalent influenza vaccine. These phenomena may possibly due to pre-existing immunogenicity at mucosal sites (7,29,30). Less than half of the vaccinees in a recent phase I clinical trial assessing safety and immunogenicity of a H7N9 LAIVs seroconverted (48%, (95% CI 29 4-67 5)) after one vaccination (31).…”
Section: Prime-boost Vaccinated Mice Intranasally Challenged With DIVmentioning
confidence: 99%