Effectiveness of Local Delivery of Alendronate in Reducing Alveolar Bone Loss Following Periodontal Surgery in Rats

Binderman, Itzhak; Adut, M.; Yaffe, Avinoam

doi:10.1902/jop.2000.71.8.1236

Cited by 74 publications

(79 citation statements)

References 22 publications

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“…Therefore, it is also possible that the addition of BP at high doses (100 and 200 μg) influenced osteoclasts, osteoclast precursors, and osteoblasts, and excessively inhibited bone metabolic turnover. In contrast, new bone increased in the 1 μg BP+DDM group, suggesting that this additive BP dose (1 μg) was close to the dose that reached the defective bone region in the abovementioned studies performed by Binderman et al (150 μg/kg) 9) and Hikita et al (1.0 mg/kg) 10) . The influence may have been limited to slight inhibition of osteoclasts and may have been too small to influence the entire bone metabolism at this dose.…”

Section: Discussionmentioning

confidence: 59%

“…In addition, it has been reported that BP administration near the extraction socket and extraction site and below the maxillary periosteum on the opposite side improved the osteochondral repair ability of the extraction socket [9][10][11] . However, it is unclear whether or not direct BP administration to the defective bone region exhibits a similar effect.…”

Section: Introductionmentioning

confidence: 99%

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Experimental study of influence of direct bisphosphonate administration on bone substitute

et al. 2015

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Section: Discussionmentioning

confidence: 59%

Section: Introductionmentioning

confidence: 99%

Experimental study of influence of direct bisphosphonate administration on bone substitute

et al. 2015

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“…Like other bisphosphonates, alendronate sodium is used for the treatment and prevention of Paget's disease, fibrous dysplasia, and osteoporosis, which are characterized by increased bone turnover and resorption 6 . Recent studies investigating the local effects and systemic side effects of alendronate sodium have shown that locally administered alendronate solution is absorbed by the bone at a rate of 20%-30% at the site of administration, where it inhibits bone resorption 7 .…”

mentioning

confidence: 99%

Effects of local alendronate administration on bone defect healing. Histomorphometric and radiological evaluation in a rabbit model

et al. 2017

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Purpose: To performed a histomorphometric and radiological study to evaluate the effects of alendronate sodium administered locally in mandibular bone defects created in rabbits. Methods: Two circular defects 5 mm in diameter were created bilaterally in the mandibular corpus of 20 New Zealand rabbits (i.e., four defects per animal). Each defect received one of four treatments: no treatment (EC group), alendronate irrigation (AL group), autogenous bone grafting (AG group), or alendronate irrigation with autogenous bone grafting (AL+AG group). Histomorphometric and radiological assessments were conducted at 4 and 8 weeks after surgery. Results: Between-group comparisons of the new bone area, the value of the AL+AG group was significantly lower thanthe remaining three groups at 4 weeks postoperatively. In all groups, the new bone area was significantly larger at 8 weeks than at 4 weeks. The residual graft area at 4 and 8 weeks was significantly higher in the AL+AG group than in the AG group, although it was significantly smaller at 8 weeks than at 4 weeks in both these groups. Conclusion: The use of alendronate sodium in conjunction with autogenous bone grafting improves the osteoconductive properties of the graft, enhances graft retention in the defect, and improves ossification.

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“…It has also been administered locally to prevent bone loss due to periodontitis in animal models [5][6][7][8]. Nevertheless the effect of bisphosphonates on ridge preservation by local application in humans remains poorly investigated.…”

Section: Introductionmentioning

confidence: 99%

The Local Effect of Alendronate with Intra-alveolar Collagen Sponges on Post Extraction Alveolar ridge Resorption: A Clinical Trial

Sarkar

Singhvi

Shetty

et al. 2014

J. Maxillofac. Oral Surg.

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Introduction Extraction of teeth is followed by resorption of the residual alveolar ridge that continues throughout life resulting in loss of alveolar height and width. Of the numerous techniques that have been used to arrest post extraction alveoloar ridge resorption, the placement of a graft material inside the socket immediately after extraction has been mostly followed. Type 1 collagen is one of the commonly used graft material that prevent resorption by providing dimensional stability to the socket.Bisphosphonates are an anti-osteoclastic drug that prevent resorption by disrupting the membrane ruffling of the osteoclasts. Alendronate a bisphosphonate, is primarily used in diseases with bone loss. It has been used to reduce active bone resorption significantly without interfering with bone mineralization and quality. The need for the study is to examine the inhibitory effect of alendronate on residual ridge resorption when applied locally in combination with type I collagen on alveolar bone immediately following tooth extraction. Materials and Methods Twenty patients with age between 30 and 65 years were selected from the out patient department of The Oxford Dental College and Hospital. The patients were divided into two groups. In the first group after extraction of teeth from premolar to midline the sockets were irrigated with saline and sutured. On the left side type I collagen sponge was placed and sutured. In the other group the right side was treated the same way after extraction as in first group where as in the left side sockets type I collagen soaked in 20 mg/ml of alendronate was placed and sutured. Patients were evaluated clinically for any local irritation as well as radiologically with orthopantomograph X-rays were taken immediately after the extraction, 1 month after extraction and 4 months after extraction to determine the amount of bone loss prevented. Results The statistically significant bone loss prevented by the collagen alone was 22.8 % and in collagen with alendronate group was 44.38 % at the end of 4 months. Conclusion Type I collagen soaked with alendronate when placed in the socket immediately after extraction of teeth prevents post-extraction alveolar ridge resorption.

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Effectiveness of Local Delivery of Alendronate in Reducing Alveolar Bone Loss Following Periodontal Surgery in Rats

Abstract: This study implies that topical delivery of alendronate at the time of surgery reduces bone loss in periodontal procedures involving mucoperiosteal flap surgery. The most effective dose is 200 microg for topical delivery at the surgical site and 400 microg for distant sites.

Cited by 74 publications

References 22 publications

Experimental study of influence of direct bisphosphonate administration on bone substitute

Experimental study of influence of direct bisphosphonate administration on bone substitute

Effects of local alendronate administration on bone defect healing. Histomorphometric and radiological evaluation in a rabbit model

The Local Effect of Alendronate with Intra-alveolar Collagen Sponges on Post Extraction Alveolar ridge Resorption: A Clinical Trial

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