Effectiveness of low-intensity pulsed ultrasound on osteoarthritis of the temporomandibular joint: A review

Tanaka, Eiji; Liu, Yao; Xia, Linze; Ogasawara, Naoko; Sakamaki, Tatsuya; Kano, Fumiya; Hashimoto, Noboru; Feng, Xiaoxing; Yamamoto, Akihito

doi:10.1007/s10439-020-02540-x

Cited by 30 publications

(23 citation statements)

References 93 publications

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“…The manifestations of TMJ OA can differ to some degree based on the model used. 37,39 Usually in the model of TMJ OA induced by surgery or drugs, OA progresses rapidly and is accompanied by redness, swelling, hyperplasia, and other inflammatory reactions, which may be useful in developing drugs for OA. It is widely known that occlusion is closely related to TMJ, and alteration of occlu-sion, such as change in molar height or incisor overjet, can lead to TMJ OA and is another model of TMJ OA.…”

Section: Discussionmentioning

confidence: 99%

“…These research models can be roughly categorized as those involving drug‐induced TMJ OA, surgically induced TMJ OA, and gene modification and oral intervention. The manifestations of TMJ OA can differ to some degree based on the model used 37,39 . Usually in the model of TMJ OA induced by surgery or drugs, OA progresses rapidly and is accompanied by redness, swelling, hyperplasia, and other inflammatory reactions, which may be useful in developing drugs for OA.…”

Section: Discussionmentioning

confidence: 99%

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Experimental functional shift–induced osteoarthritis‐like changes at the TMJ and altered integrin expression in a rat model

Zou

Cai

Lin

et al. 2022

Annals of the New York Academy of Sciences

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Mandibular deviation affects the biomechanical environment of the temporomandibular joint (TMJ) and causes thinning of cartilage on the deviated side. We aimed to evaluate, using a rat model, the effect of mandibular functional deviation on the TMJ in relation to the functional roles of integrin β family members. The effects of experimental functional deviation on the TMJ of 6-week-old Sprague-Dawley female rats, randomly assigned to control (n = 42) and experimental groups (n = 42), were evaluated at 3 days and 1, 2, 4, and 8 weeks by histological staining, immunofluorescence, real-time quantitative polymerase chain reaction, and micro-computed tomography. The results showed that the experimental functional shift changed the shape of condyles, thinned the cartilage, and increased the proportion of the hypertrophic layer on the deviated sides of condyles. In addition, the extracellular matrix of the condyle cartilage exhibited degradation at 1 week and subchondral trabecular bone was lost at 4 and 8 weeks. Osteoarthritis (OA)-like changes occurred in the left and right condyles of rats in the experimental group and were aggravated over time. Integrin β family expression, especially integrin β 2 , was altered from week 1, possibly related to the OA-like changes. These data may provide insight into the onset of TMJ OA.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Experimental functional shift–induced osteoarthritis‐like changes at the TMJ and altered integrin expression in a rat model

Zou

Cai

Lin

et al. 2022

Annals of the New York Academy of Sciences

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“…Therapeutic benefits by ultrasound on articular cartilage repair and regeneration have been studied in various animal models [ 24 , 25 ]. Ultrasound-induced chondrogenic progenitor cell migration has been characterized in both monolayer culture and fibrin hydrogel-embedded cartilage defects [ 26 , 27 ].…”

Section: Discussionmentioning

confidence: 99%

Piezoelectric effect stimulates the rearrangement of chondrogenic cells and alters ciliary orientation via atypical PKCζ

Lim

Liu

Chu

et al. 2022

Biochemistry and Biophysics Reports

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“…Ultrasound (US) has been studied for treating temporomandibular joint osteoarthritis (TMJ-OA) 16 and hypoxia-induced chondrocyte damage in temporomandibular disorders, 17 since it is recognized as a stimulator if used at low-intensity level, and would promote neovascularization, differentiation of mesenchymal stem cells and local release of angiogenic factors that action on ischemic tissues due to improved blood flow. 18–20 Some preliminary studies show that US is effective in treating TMJ disorders and relieving pain, particularly if it is used in combination with an ice bath.…”

Section: Introductionmentioning

confidence: 99%

Ultrasound is Effective to Treat Temporomandibular Joint Disorder

Ba¹,

Zhou²,

Yu³

2021

JPR

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Background Temporomandibular joint disorder (TMD) affects millions of people. It is unclear if low intensity ultrasound (US) is effective to treat TMD. Methods A total of 160 patients with TMD were enrolled in this study. The subjects were randomized into two groups to receive US therapy or no therapy. Patients in the US group were given US therapy once a day for 5 days per week for 2 consecutive weeks. Before and 4 weeks and 6 months after the treatments, the patients were assessed for pain using visual analog scale (VAS) and the maximum pain-free inter-incisal distance (IID). In addition, mandibular movement (MM), jaw noise (JN), disability index (DI) and craniomandibular index (CMI) were also assessed. Results Compared with the patients before the therapy, VAS, IID, MM, JN, DI and CMI in the US group were significantly improved 4 weeks and 6 months after therapy. However, 6 months after the therapy, US group had a recurrence rate of 2.63%. Conclusion US therapy can significantly reduce the pain, and improve the functionality of the temporomandibular joint and mouth opening limit for TMD patients, and is therefore recommended for TMD patients.

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Effectiveness of low-intensity pulsed ultrasound on osteoarthritis of the temporomandibular joint: A review

Cited by 30 publications

References 93 publications

Experimental functional shift–induced osteoarthritis‐like changes at the TMJ and altered integrin expression in a rat model

Experimental functional shift–induced osteoarthritis‐like changes at the TMJ and altered integrin expression in a rat model

Piezoelectric effect stimulates the rearrangement of chondrogenic cells and alters ciliary orientation via atypical PKCζ

Ultrasound is Effective to Treat Temporomandibular Joint Disorder

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