Effectiveness of &lt;em&gt;Cucumis sativus&lt;/em&gt; extract versus glucosamine-chondroitin in the management of moderate osteoarthritis: a randomized controlled trial

Nash, Robert J.; Azantsa, Boris Gabin Kingue; Sharp, Hazel; Shanmugham, Velmurugan

doi:10.2147/cia.s173227

Cited by 17 publications

(13 citation statements)

References 26 publications

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“…For a human subject weighing 60 kg the equivalent cucumber extract (Q-Actin) dose from the animal study where no adverse effects were noted will be 60,000 mg/person/day. The findings from the present subchronic animal toxicity study, where a 6000-fold higher dose as compared to the human study (10 mg/day) in which no adverse effects were observed (Nash & Azantsa, [ 12 ], further support the safe use of Q-Actin in human.…”

Section: Discussionsupporting

confidence: 70%

“…Cucumber fruit contains a unique iminosugar, ido-BR1, shown to have anti-inflammatory properties, prompting interest in human application. In a six-month (180 days) randomized, double-blind clinical trial in 122 patients diagnosed with osteoarthritis, Nash & Azantsa [ 12 ] compared the effects of cucumber extract (Q-Actin) with that of a combination of glucosamine hydrochloride and chondroitin sulphate (GC). The patients received either 10 mg of Q-Actin or 1350 mg of GC (control) twice a day for 180 days.…”

Section: Discussionmentioning

confidence: 99%

“…This iminosugar, Ido-BR1, can directly reduce TNF-ɑ, a cytokine involved in acute and systemic inflammation, in human blood, leading to interest for human use. Q-Actin a standardized extract has recently been evaluated in a human clinical trial for anti-inflammatory effects with promising results [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

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Safety assessment of a standardized cucumber extract (Q-Actin™): Oral repeat-dose toxicity and mutagenicity studies

Kothari¹,

Saravana²,

Muthusamy³

et al. 2018

Toxicology Reports

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Cucumus sativus (cucumber) is one of the most widely consumed fruit vegetables worldwide. Recent discovery of iminosugars in commonly consumed fruits and vegetables has promoted the interest in isolating these compounds and understanding the potential benefits to human health. The objective of the present study was to investigate the general toxicity and mutagenic effects of an aqueous extract of cucumber (Q-Actin), standardized to ≥1% (1–2%) ido-BR1 iminosugar. Single dose of Q-Actin was well tolerated without mortality at 2000 mg/kg body weight (bw) in Sprague Dawley rats. Oral (gavage) administration of Q-Actin up to 1000 mg/kg bw/day was well tolerated followed by repeated administration for a maximum period of 90 days in Sprague-Dawley rats. There were no treatment related changes in clinical observations, ophthalmic examinations, body weights and body weight gains or feed consumption, clinical chemistry and pathological changes compared to control. The mutagenicity as evaluated by Ames assay, in vitro chromosomal aberration test and in vivo micronucleus assay did not reveal any potential of Q-Actin to induce genotoxicity. The results showed that Q-Actin is well tolerated in general toxicity studies and did not induce mutagenicity. The no-observed-adverse-effect level (NOAEL) of the standardized aqueous cucumber extract (Q-Actin) is considered to be ≥1000 mg/kg bw/day, followed by repeated administration for90 days.

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Section: Discussionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 99%

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Safety assessment of a standardized cucumber extract (Q-Actin™): Oral repeat-dose toxicity and mutagenicity studies

Kothari¹,

Saravana²,

Muthusamy³

et al. 2018

Toxicology Reports

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“…Além de ser utilizado na alimentação, é matéria-prima para fabricação de cosméticos (MUKHERJEE et al, 2013). Nash et al (2018) estudaram o efeito de um extrato aquoso do pepino em um ensaio clínico randomizado, duplocego, de grupos paralelos, com 122 pacientes (56 homens e 66 mulheres) com diagnóstico de osteoartrite moderada do joelho. Ensaios, v. 24, n. 3, p. 273-282, 2020…”

Section: Pepino (Cucumis Savitus)unclassified

Bebidas Mistas de Frutas e Vegetais no Contexto de Alimentação Saudável: uma Revisão de Literatura

2020

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Este trabalho objetivou realizar uma revisão de literatura sobre bebidas mistas de frutas e vegetais e seus principais componentes no contexto do consumo alimentar. O presente estudo é uma revisão narrativa elaborada a partir da consulta em diferentes bases de dados, como: Web of science e Science Direct. Optou-se pela busca por termos livres. Os termos juice, drinks foram combinados com as palavras fruits “AND” vegetables para localizar estudos sobre os dois temas. Posteriormente, a fim de selecionar estudos com os principais componentes das bebidas mistas, foram utilizados os termos livres “citrus limon”, “Malus domestica”, “Ananas comosus”, “Cucumis savitus”, “Brassica oleracea”, “Spinacia oleracea”, “Zingiber officinale” e “Mentha ssp”. O critério de inclusão dos trabalhos foi pautado na seleção de materiais que tivessem por objetivo estudar os efeitos isolados do consumo dos principais ingredientes das bebidas mistas, como também os artigos que utilizaram a bebida mista com alegação “detox” nos estudos. O direcionamento dos artigos selecionados está relacionado com a prospecção da atividade antioxidante e, apesar da composição das bebidas ser diversificada, destacam-se o uso de maçã, de repolho e de pepino como ingredientes das preparações. As bebidas mistas, sucos ou smoothies apresentaram variável composição que determina os atributos sensoriais, composição físico-química, compostos bioativos e atividade antioxidante. Palavras-chave: Suco. Nutrição. Alimentação. Abstract This study aimed to conduct a literature review on mixed fruit and vegetable drinks and their main components in the context of food consumption. The present study is a narrative review elaborated from the consultation in different databases, such as Web of science and Science Direct databases. It was chosen to search free terms. The terms juice, drinks were combined with the words fruits “AND” vegetables to locate studies on both themes. Subsequently, in order to select studies with the main components of mixed drinks, the free terms "citrus limon", "Malus domestica", "Ananas comosus", "Cucumis savitus", "Brassica oleracea", "Spinacia oleracea" ”,“ Zingiber officinale ”and “Mentha ssp ”. The inclusion criterion of the studies was based on the selection of materials that aimed to study the effects of vegetable consumption alone, which are the main ingredients of mixed drinks and included articles that used the mixed drink or juices with claim “detox” in the studies. The direction of the selected studies is related to the prospecting of antioxidant activity and, although the drinks composition is diverse, the use of apple, cabbage and cucumber as ingredients of the preparations stand out. Plant foods are important sources of nutrients for food. The mixed drinks, juices or smoothies presented variable composition that determines the sensory attributes, physicochemical composition, bioactive compounds and antioxidant activity. Keywords: Juice. Nutrition. Food.

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“…Self-management (SM) refers to the individual’s capability to manage lifestyle, mental and physical changes caused by the illness, the symptoms, and treatment of the disease, hence requiring the acquisition of skills to cope with the disease (24). Some patients are not fully aware of the management and control of their illnesses (25, 26). The patients cannot make effective health-related decisions since they usually lack the self-care skills (27).…”

Section: Introductionmentioning

confidence: 99%

Effect of Self-Management Program on Pain and Disability Index in Elderly Men with Osteoarthritis

et al. 2019

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Background: Osteoarthritis (OA) is a progressive disease of the joints, leading to decreased function and disability. Objectives: The study aimed to investigate the effect of self-management (SM) program on disability index and pain in aging men with knee OA. Methods: The study included an SM group and a control group. Given the sample size of the previous studies, 83 patients were recruited. The study tools included a demographic profile questionnaire, visual analogue scale (VAS), and HAQ 8-item DI. The intervention included 10 SM sessions for patients in the SM group (8 sessions of in-person intervention and 2 sessions of telephone intervention). Patients were placed in groups of 7, and the sessions were held weekly each for a period of 45 to 60 minutes. Data were analyzed using descriptive and analytical tests by SPSS V. 16 software. Results: The two groups(SM and control group) were homogeneous in terms of demographic characteristics (P > 0.05). The mean (SD) disability score was 19.12 (1.92) in the SM group before the intervention, which reduced to 14.70 (1.63) after the intervention (P = 0.000, T = 10.02). The mean (SD) pain score, was 9.19 (0.71) in the SM group before the intervention, which reduced to 6.48 (0.84) after the intervention (P = 0.000, T = 18.15). Conclusions: Training can help patients perform SM measures and improve their health status by enhancing the information needed for the disease.

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Effectiveness of <em>Cucumis sativus</em> extract versus glucosamine-chondroitin in the management of moderate osteoarthritis: a randomized controlled trial

Cited by 17 publications

References 26 publications

Safety assessment of a standardized cucumber extract (Q-Actin™): Oral repeat-dose toxicity and mutagenicity studies

Safety assessment of a standardized cucumber extract (Q-Actin™): Oral repeat-dose toxicity and mutagenicity studies

Bebidas Mistas de Frutas e Vegetais no Contexto de Alimentação Saudável: uma Revisão de Literatura

Effect of Self-Management Program on Pain and Disability Index in Elderly Men with Osteoarthritis

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