Effectiveness of magnetocardiography to identify patients in need of coronary artery revascularization: a cross-sectional study

Abstract

Background: Patients with angina-like symptoms need invasive or non-invasive angiography to determine whether revascularization is necessary. For patients in need of revascularization, undergoing coronary computed tomography angiography (CCTA) may delay the treatment of revascularization and increase exposure to contrast agents and radiation. The aim of this cross-sectional study was to accessed the effectiveness of magnetocardiography (MCG) to identify patients who should undergo coronary revascularization. Methods: A total of 203 patients who were suffering from angina-like symptoms and underwent percutaneous coronary angiography (PCA) between July 27, 2015 and April 10, 2017 at the 8th Medical Center of Chinese PLA General Hospital, were enrolled in this cross-sectional study. In all patients, 12lead electrocardiography (ECG) and MCG test were performed before PCA. For each subject. The value at every single sampling point was extracted from T wave of each MCG channel in time sequence. Pearson's correlation coefficients were calculated for each two T-waves. A binary logistic regression diagnosis model of these coefficients was established to identify patients in need of revascularization.Results: Ten pairings of coefficients were entered into diagnostic regression model as covariates. The area under the receiver operating characteristic (ROC) curve (AUC) was 0.747 (95% CI: 0.680-0.815), and the asymptotic P value was less than 0.001. At the cut-off value of 0.55, the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy were 72.9%, 65.9%, 74.8%, 63.6% and 69.9%, and the positive and negative post-test probabilities were 65.9% and 25.7%. The accuracy, sensitivity, specificity, PPV and NPV for 12-lead ECG were 67.0%, 62.7%, 63.5%, 70.5% and 55.1%, respectively. However, when those acute myocardial infarction (AMI) patients were ruled out from both

Clinical magnetocardiography: the unshielded bet—past, present, and future

“…Obviously, high-performance EMS still remains the preferred choice when the highest possible high resolution is needed, especially for experimental research. Instead, as concerns most routine clinical MCG applications, there is an increasing evidence that progress in magnetic sensor technology combined with more advanced signal denoising methods is rapidly reaching the requirements for the near-future availability of several novel device variants for budget-price unshielded MCG, covering the needs of different deployment scenarios, from ED triage for suspected ACS (87,259) to largescale screenings of ambulatory patients (189) and to contactless monitoring during interventional cardiology (128) or badly burned patients and even foreseen for dynamic long-term assessment of cardiac MF dynamics (285).…”

“…While clinical studies, which was carried out in specialized centers with shielded and unshielded SQUID-based MCG systems, enhanced the evidence for MCG 3D electroanatomical localization accuracy and for risk assessment of arrhythmogenic mechanisms/substrates ( 82 , 83 , 90 , 226 , 245 – 251 ), a renewed interest for biomagnetic sensor technology has raised again not only at the academic but also at the industrial level ( 252 , 253 ). In fact, apart from the traditionally available multichannel cryogenic MCG systems working in MSRs ( 246 , 254 – 259 ) and a more downscaled price for sequential unshielded MCG mapping ( 77 , 256 – 259 ), three younger companies have manufactured innovative multichannel MCG devices, based on different sensor technologies, all of them specifically designed for clinical application at minimized running costs and with optimized operational simplicity. All of them have gathered regulatory clearance for the recording of human cardiac magnetic fields.…”

Accurate diagnosis of severe coronary stenosis based on resting magnetocardiography: a prospective, single-center, cross-sectional analysis

“…The magnetic pole angle was defined as that is from the center point of positive pole to the center point of negative pole in the coordinate. [16]…”