Effectiveness of meticillin-resistant Staphylococcus aureus decolonization in long-term haemodialysis patients: a systematic review and meta-analysis

Gebreselassie, Hiwot Mamo; Priore, Elia Lo; Marschall, Jonas

doi:10.1016/j.jhin.2015.08.015

Cited by 27 publications

(11 citation statements)

References 28 publications

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“…Therefore, it is necessary to pay great attention to nasal luid specimens in hemodialysis patients. A meta-analysis on six published cohort studies indicated that among 1150 hemodialysis patients, methicillin-resistant S. aureus (MRSA) was isolated from nasal swabs of 147 (12.8%) patients [23], which is lower than the percentages in the present study. This difference is due to the fact that we have reported the whole infections and they have considered MRSA as the most important pathogen in resistant BSI.…”

Section: Discussioncontrasting

confidence: 78%

Can bloodstream infection be predicted by nasal culture in hemodialysis patients?

Broumand¹,

Boroumandi²,

Rahbar³

et al. 2019

J Clini Nephrol

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The blood and drainage cultures are suggested for early diagnosis of bloodstream infection (BSI), which are time consuming and laborious. Nasal colonization of bacteria is one of the modalities, occasionally can predict BSI. We hypothesized that nasal culture, as an accessible fl uid may be helpful to predict future BSI in hemodialysis patients. The present prospective study evaluated 63 patients undergoing maintenance hemodialysis at the Pars hospital dialysis center, Tehran, Iran, from November 2015 until February 2016. Nasal fl uid of patients were collected from the 1-cm internal anterior part of both nostrils of patients by a sterile swab and cultured in Trypticase soy agar. All patients were followed for three months for BSI. The results of fi rst nasal fl uid sample revealed that 33.3% in fi rst sampling and 27.0% in sampling had positive nasal fl uid culture. The type of bacteria in all positive cases was Staphylococcus aureus. The rate of BSI infection in the patients with positive and negative fi rst nasal fl uid culture was 9.5% and 2.4% respectively with no signifi cant difference. We found also no signifi cant association between BSI positivity and nasal culture results so that positive BSI was revealed in 5.9% of patients with positive nasal fl uid culture and 4.3% in those with negative nasal fl uid culture with no meaningful difference. None of the baseline variables including age and gender, underlying risk factor, access, or duration of dialysis was associated with BSI positivity. In hemodialysis patients, BSI may not be predicted by nasal fl uid culture positivity.

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Section: Discussioncontrasting

confidence: 78%

Can bloodstream infection be predicted by nasal culture in hemodialysis patients?

Broumand¹,

Boroumandi²,

Rahbar³

et al. 2019

J Clini Nephrol

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“…Antiseptic agents such as chlorhexidine digluconate (chlorhexidine, CHX), octenidine dihydrochloride (OCT), polyhexanide (polyhexamethylene biguanide, PHMB), PVP-iodine (Poly(vinylpyrrolidone)-iodine complex, PVP-I), and triclosan (5-chlorine-2-(2,4-dichlorphenoxy)-phenol, TCX) are widely used as topical antiseptics against colonization and infection of humans and animals with Methicillin-resistant Staphylococcus aureus (MRSA) [1–7]. The clinical benefits of decolonization of MRSA patients for prevention of nosocomial infections is well documented [8–10]. The antimicrobial properties of these agents against hospital acquired (HA) MRSA strains have been repeatedly shown [11–17].…”

Section: Introductionmentioning

confidence: 99%

Susceptibility of livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) to chlorhexidine digluconate, octenidine dihydrochloride, polyhexanide, PVP-iodine and triclosan in comparison to hospital-acquired MRSA (HA-MRSA) and community-aquired MRSA (CA-MRSA): a standardized comparison

Dittmann

Schmidt

Müller

et al. 2019

Antimicrob Resist Infect Control

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Background Recent publications have raised concerns of reduced susceptibilities of clinical bacterial isolates towards biocides. This study presents a comparative investigation of the susceptibility of livestock-associated Methicillin-resistant Staphylococcus aureus (LA-MRSA), hospital-acquired MRSA (HA-MRSA) and community-aquired MRSA (CA-MRSA) to the commonly used antiseptics chlorhexidine (CHX), octenidine (OCT), polyhexanide (PHMB), PVP-iodine (PVP-I) and triclosan (TCX) based on internationally accepted standards. Methods In total, 28 (18 LA-, 5 HA- and 5 CA) genetically characterized MRSA strains representing a broad spectrum of hosts, clonal complexes and spa-types, as well as the reference methicillin-sensitive Staphylococcus aureus (MSSA) strain ATCC 6538, were selected. Minimal inhibitory concentration (MIC) and minimal microbicidal concentration (MBC) were determined in accordance with DIN 58940–7, 58940–8 and DIN EN ISO 20776-1. The microbicidal efficacy was determined in accordance with DIN EN 1040. Results Results from the MIC/MBC and quantitative suspension tests revealed differences between antiseptic substances but not between epidemiological groups of MRSA strains. OCT and PHMB were the most active substances with a minimal MIC of 1 mg/L, followed by CHX (2 mg/L), TCX (32 mg/L) and finally PVP-I (1024 mg/L). The MSSA reference strain showed a tendency to a higher susceptibility compared to the MRSA strains. Conclusions This investigation of the susceptibility of a range of LA-, HA- and CA-MRSA strains using standardized conditions gave no indication that LA-MRSA strains are less susceptible to commonly used antiseptics compared to HA- and CA-MRSA strains.

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“…Most typically, aerobic Gram‐positive cocci such as Staphylococcus serve as the contaminant, with resistant pathogens such as MRSA representing an increasing proportion of infections in recent years . Such infections play a major role in patients undergoing haemodialysis, after total hip and knee arthroplasty, cardiac surgery, recurrent staphylococcal skin infections, especially for patients with atopic dermatitis and soft tissue infections . Decolonization is considered important in critical care medicine .…”

mentioning

confidence: 99%

Photodynamic inactivation of bacteria to decolonize meticillin-resistant Staphylococcus aureus from human skin

et al. 2018

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Effectiveness of meticillin-resistant Staphylococcus aureus decolonization in long-term haemodialysis patients: a systematic review and meta-analysis

Cited by 27 publications

References 28 publications

Can bloodstream infection be predicted by nasal culture in hemodialysis patients?

Can bloodstream infection be predicted by nasal culture in hemodialysis patients?

Photodynamic inactivation of bacteria to decolonize meticillin-resistant Staphylococcus aureus from human skin

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