Effectiveness of modern anthelmintic agents for strongylatoses sheep digestive canal

Abstract

Currently, the use of anthelmintic agents is considered to be one of the fastest and most practical ways to combat strongylates sheep's digestive tract. Despite the wide assortment of anthelmintic preparations both in the world market and in Ukraine, veterinary specialists are increasingly noticing the low level of efficacy of medicines. Scientists have found that the emergence of resistance in nematodes to the action of anthelmintic agents is due to their excessive and uncontrolled use. In view of the above, regular monitoring of the state of anthelmintic resistance, as part of the program for the control of strongylatoses sheep digestive canal, is a priority area of research. Therefore, the purpose of the study was to evaluate the anthelmintic efficacy of drugs of different chemical groups (benzimidazoles, imidotiazole, macrolides, and combination drugs) for strongylatoses sheep digestive canal with regard to their method of administration. Medicines (Brovalsen, Albendazole-250, Albendazole 10%; Brovalevamisole 8%, Levavet 10%; Univerm, Ivermekvet 1%; Kloziveron, Kombitrem) have been shown to have anthelmintic action (EE – 50–100%, IE – 76.20–100%) against the pathogens of gastrointestinal strongylates. It was noted that their effectiveness depended on the method of administration and the chemical group to which they belonged. The most effective (EE and IE reached 100%) were injectable drugs Ivermekvet 1%, Kloziveron and Levavet 10 %, administered by single subcutaneous injection. Less effective was the use of a suspension of Albendazole 10% and Kombitrem emulsion for individual feeding, as well as powders of Brovalevamisole 8% and the Univerm for both individual and group feeding. The indicators of their EE and IE varied between 60–90% and 88.45–92.63% respectively. The Brovalsen drug, which was administered to animals by group feeding, was ineffective, with EE and IE being 50 and 76.20%, respectively. The results of the obtained data will allow to increase the efficiency of conducting therapeutic and preventive measures for strongylatoses digestive canal in sheep farms of different forms of ownership.