Effectiveness of n-3 fatty acids in the treatment of hypertriglyceridemia in HIV/AIDS patients: a meta-analysis

Vieira, Aline Doria Sobral; Silveira, Glória Regina Mesquita da

doi:10.1590/1413-81232017228.21752015

Cited by 14 publications

(8 citation statements)

References 36 publications

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“…Very few studies have investigated the role of n-3 PUFA in PLWH. n-3 PUFA, or fish oil, supplementation has been shown to be beneficial in general for people with hypertriglyceridemia [50] as well as PLWH [51,52]. In the present study, we found that DHA and the ratio of DHA/AA were negatively correlated with baseline CIMT score.…”

Section: Discussionsupporting

confidence: 57%

Relationships between Atherosclerosis and Plasma Antioxidant Micronutrients or Red Blood Cell Polyunsaturated Fatty Acids in People Living with HIV

et al. 2019

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Background: People living with human immunodeficiency virus infection and acquired immune deficiency syndrome (HIV/AIDS) (PLWH) are at an increased risk of cardiovascular disease. Diet-related factors may contribute. The aim of this pilot study was to determine, in PLWH, the relationship between atherosclerosis assessed by carotid intima-media thickness (CIMT) and (A) plasma antioxidant micronutrients and oxidative stress or (B) red blood cell polyunsaturated fatty acids (RBC PUFA), particularly long chain omega-3 polyunsaturated fatty acids (n-3 PUFA). Methods: (A) In a cross-sectional study, subjects had CIMT evaluated by high resolution carotid artery ultrasound. Plasma was collected for vitamin C, measured by spectrophotometry; and alpha- and gamma-tocopherol, retinol, and malondialdehyde—a marker of oxidative stress—using high pressure liquid chromatography and fluorescence spectrophotometry. (B) In a prospective cohort study, other subjects had RBC PUFA measured at baseline, using gas chromatography, and CIMT assessed at baseline and repeated after 2 years. Clinical data was also collected. Results: (A) 91 PLWH participated. Only alpha- and gamma-tocopherol levels were positively correlated with CIMT. In a multivariate analysis, age and systolic blood pressure were significantly associated with CIMT with gamma-tocopherol near significance (p = 0.053). (B) 69 PLWH participated. At baseline, docosahexaenoic acid (n-3 PUFA) and the ratio of docosahexaenoic acid to arachidonic acid (n-6 PUFA) were significantly and negatively correlated with CIMT. However, a multivariate analysis failed to detect a significant relationship either at baseline or 2 years after. Conclusion: In addition to age and systolic blood pressure, atherosclerosis assessed by CIMT might be associated with higher serum gamma-tocopherol levels. There was a non-significant association between CIMT and RBC n-3 PUFA or the ratio of n-3 to n-6 PUFA.

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Section: Discussionsupporting

confidence: 57%

Relationships between Atherosclerosis and Plasma Antioxidant Micronutrients or Red Blood Cell Polyunsaturated Fatty Acids in People Living with HIV

et al. 2019

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“…Fish oils are also known to have beneficial effects in diabetic patients (Pinel et al, 2014). Moreover, fatty acids have been reported to have positive effects in the treatment of patients with AODS (Vieira & Silveira, 2017;Tort et al, 2016). Given the high benefits of consuming seafood in human health, the American Heart Association Nutrition Committee suggests eating fish of 2 or 3 times a week (Kris-Etherton et al, 2003;Mnari et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Fish oil for human health: omega-3 fatty acid profiles of marine seafood species

Durmuş

2019

Food Sci. Technol

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“…The greatest reduction was seen among people with advanced hypertriglyceridaemia. Numerous studies have shown measurable benefits from incorporating omega-3 supplementation into pharmacotherapy [27] also in the HIV population [25,28,[31][32][33][34]. However, benefits of supplementation have not been established for protease inhibitors [10].…”

Section: Discussionmentioning

confidence: 99%

Effect of diet on lipid profile in HIV-infected patients

Jackiewicz¹,

Czarnecki²,

Knysz³

2018

HIV & AIDS Review

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The implementation of highly active antiretroviral therapy has increased the life expectancy of people living with human immunodeficiency virus (HIV), thus reducing the number of deaths from acquired immune deficiency syndrome. Nowadays life expectancy of HIV(+) patients is comparable to those who are not infected. However, due to the use of antiretroviral therapy and the persistent immune activation and inflammation caused by HIV, other negative events may occur including dyslipidaemias, cardiovascular disorders, chronic kidney disease, early ageing, and neurocognitive impairment. It also increases the risk of developing metabolic syndrome and becomes a risk factor for cardiovascular disease: e.g. hypertension, brain stroke, and heart infarct. Comprehensive care of HIV patients with disturbed lipid profile includes lifestyle modifications such as dietary changes along with smoking cessation and has a beneficial effect on the lipid profile (total cholesterol, LDL, HDL, triglyceride levels). Therefore, it can reduce the risk of cardiovascular disease, allows the patients to avoid additional pharmacotherapy, and can eliminate drug-drug interactions with antiretroviral drugs. There are a lot of data showing that early dietary intervention and consistent diet control have a beneficial effect on lipid disorders in HIV-infected patients. Clinicians should be aware of it. In view of the benefits that can be gained by people living with HIV from dietary intervention, it is appropriate to include dieticians in a panel of specialists who take care of HIV(+) patients.

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Effectiveness of n-3 fatty acids in the treatment of hypertriglyceridemia in HIV/AIDS patients: a meta-analysis

Cited by 14 publications

References 36 publications

Relationships between Atherosclerosis and Plasma Antioxidant Micronutrients or Red Blood Cell Polyunsaturated Fatty Acids in People Living with HIV

Relationships between Atherosclerosis and Plasma Antioxidant Micronutrients or Red Blood Cell Polyunsaturated Fatty Acids in People Living with HIV

Fish oil for human health: omega-3 fatty acid profiles of marine seafood species

Effect of diet on lipid profile in HIV-infected patients

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