Effectiveness of nanoscale delivery systems on improving the bioavailability of lutein in rodent models: a systematic review

Zhang, Yanqi; Kong, Lingyan; Tan, Libo

doi:10.1080/10408398.2020.1853035

Cited by 14 publications

(9 citation statements)

References 72 publications

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“…This study did not suggest significant relations between MetS and dietary L/Z intakes in quartiles 2 and 3. Given the low absorption rate of lutein, it is plausible that the intakes of L/Z in these 2 quartiles were not high enough for optimal bioavailability and functionality ( 29 ).…”

Section: Discussionmentioning

confidence: 99%

Association between Dietary Lutein/Zeaxanthin Intake and Metabolic Syndrome among US Females: An Analysis of National Health and Examination Surveys 2015–2018

Zhang

Knol

Tan

2021

Current Developments in Nutrition

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The prevalence of metabolic syndrome (MetS) is greater among U.S. females than males, mainly due to higher risks of dyslipidemia and hyperglycemia. Lutein and zeaxanthin (L/Z) are carotenoids that can alter the composition of lipoproteins, which may affect components of MetS. However, little is known about the association between L/Z intake and MetS, especially in females. The purpose of this study was to explore the relationship between dietary L/Z or dietary plus supplemental L/Z intakes and MetS in women (n = 630), aged 20-50, participating in the National Health and Nutrition Examination Survey 2015-2018. Compared to the lowest quartile, women in the highest quartile of dietary L/Z intake had significantly lower risk of MetS after adjusting for confounders (OR = 0.46; 95% CI: 0.21, 0.98). No significant relationship was noted between dietary plus supplemental L/Z intake and MetS. Future cohort studies should investigate the effects of L/Z on MetS development in women.

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Section: Discussionmentioning

confidence: 99%

Association between Dietary Lutein/Zeaxanthin Intake and Metabolic Syndrome among US Females: An Analysis of National Health and Examination Surveys 2015–2018

Zhang

Knol

Tan

2021

Current Developments in Nutrition

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“…Nano-emulsion has a small volume and a relatively higher interface area, which is not only conducive to digestion but also beneficial for improving bioactive substances’ utilization rate [ 102 , 103 ]. Protein-stabilized oil-in-water emulsions have been widely used in the encapsulation of hydrophobic active substances, and they have a markedly protective effect on lutein [ 104 , 105 ], lycopene [ 106 ], lemon essential oil [ 107 ], and other active substances. The chemical breakdown rate of lutein decreased in the generated lutein-rich sodium caseinate nano-emulsions, and the nano-emulsions could stay stable after 30 days at 4 °C storage [ 108 ].…”

Section: Construction Of Protein Nanoparticle Carriersmentioning

confidence: 99%

Research Progress of Protein-Based Bioactive Substance Nanoparticles

Han

Liu

et al. 2023

Foods

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Bioactive substances exhibit various physiological activities—such as antimicrobial, antioxidant, and anticancer activities—and have great potential for application in food, pharmaceuticals, and nutraceuticals. However, the low solubility, chemical instability, and low bioavailability of bioactive substances limit their application in the food industry. Using nanotechnology to prepare protein nanoparticles to encapsulate and deliver active substances is a promising approach due to the abundance, biocompatibility, and biodegradability of proteins. Common protein-based nanocarriers include nano-emulsions, nano-gels, nanoparticles, and nano complexes. In this review, we give an overview of protein-based nanoparticle fabrication methods, highlighting their pros and cons. Additionally, we discuss the applications and current issues regarding the utilization of protein-based nanoparticles in the food industry. Finally, we provide perspectives on future development directions, with a focus on classifying bioactive substances and their functional properties.

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“…However, the potential of lutein as a nutritional intervention is hindered by its low stability, poor water solubility, and low oral bioavailability [20]. As a lipophilic compound, lutein depends on the formation of micelles with lipids and bile acids in the small intestine for absorption, resulting in a lower absorption rate as compared to water-soluble substances [21].…”

Section: Introductionmentioning

confidence: 99%

“…Encapsulation systems, such as oil-in-water (O/W) emulsion, have shown promise in enhancing lutein stability and bioavailability in adult human and rodent models [20,23]. An O/W emulsion contains oil droplets carrying the lipophilic compound and dispersed in a continuous water phase, stabilized by emulsifiers.…”

Section: Introductionmentioning

confidence: 99%

Utilization of Biopolymer-Based Lutein Emulsion as an Effective Delivery System to Improve Lutein Bioavailability in Neonatal Rats

Zhang,

Kong,

Lawrence

et al. 2024

Nutrients

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Newborns’ eyes and brains are prone to oxidative stress. Lutein has antioxidant properties and is the main component of macular pigment essential for protecting the retina, but has low bioavailability, thereby limiting its potential as a nutritional supplement. Oil-in-water emulsions have been used as lutein delivery systems. In particular, octenylsuccinated (OS) starch is a biopolymer-derived emulsifier safe to use in infant foods, while exhibiting superior emulsifying capacity. This study determined the effects of an OS starch-stabilized lutein emulsion on lutein bioavailability in Sprague-Dawley neonatal rats. In an acute study, 10-day-old pups received a single oral dose of free lutein or lutein emulsion, with subsequent blood sampling over 24 h to analyze pharmacokinetics. The lutein emulsion group had a 2.12- and 1.91-fold higher maximum serum lutein concentration and area under the curve, respectively, compared to the free lutein group. In two daily dosing studies, oral lutein was given from postnatal day 5 to 18. Blood and tissue lutein concentrations were measured. The results indicated that the daily intake of lutein emulsion led to a higher lutein concentration in circulation and key tissues compared to free lutein. The OS starch-stabilized emulsion could be an effective and safe lutein delivery system for newborns.

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Effectiveness of nanoscale delivery systems on improving the bioavailability of lutein in rodent models: a systematic review

Cited by 14 publications

References 72 publications

Association between Dietary Lutein/Zeaxanthin Intake and Metabolic Syndrome among US Females: An Analysis of National Health and Examination Surveys 2015–2018

Association between Dietary Lutein/Zeaxanthin Intake and Metabolic Syndrome among US Females: An Analysis of National Health and Examination Surveys 2015–2018

Research Progress of Protein-Based Bioactive Substance Nanoparticles

Utilization of Biopolymer-Based Lutein Emulsion as an Effective Delivery System to Improve Lutein Bioavailability in Neonatal Rats

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