Effectiveness of natural oral contrast agents in magnetic resonance imaging of the bowel

Abstract

Purpose: The purpose was to find an oral contrast agent that can be utilized in MRI of the small bowel and fulfill the following criteria: natural, with no or minimal side effects, nonexpensive, causes the maximum bowel distension and has the best imaging quality with no artifacts. Methods: Fourteen healthy volunteers were included. Each volunteer underwent 3 MRI examinations on different days using 3 different oral contrast materials; water, milk and pineapple juice. Coronal T2WI MRI was done at KAUH Diagnostic Radiology department. Standardized questionnaire was used to study post-MRI abdominal complaint. Statistical analysis was done using SPSS program version 17.0. Results: All tested contrast agents could significantly distend the small bowel loops with the p value <0.05. Pineapple juice could distend up to 5 segments in 7 volunteers. Good image quality was depicted in 50% of volunteers using juice, while water showed the worst results where 75% had bad image quality. The highest percentage of image artifacts was found with milk (64.3%). Conclusion: Pineapple juice has the highest ability of bowel distention and good image quality with insignificant image artifacts and no reported side effects.

Automatic assessment of human gastric motility and emptying from dynamic 3D magnetic resonance imaging

“…31 A bright intra-gastric intensity is essential to facilitate automated image segmentation. While the most common contrast meal used in gastric MRI studies is a soupbased diet or caloric liquid nutrient (eg, Ensure) with the addition of paramagnetic MRI contrast agents (eg, gadolinium chelates), 32 some studies have proposed to use naturalistic contrast meal such as blueberry or pineapple juice because they contain a high level of manganese 30,33,34 ; the use of naturalistic contrast meal is advantageous because it avoids potential safety concerns of an otherwise fabricated contrast agent. Here, we identified that firm tofu is also a high manganese food that contains 1.2 mg of manganese per 100 g tofu.…”

Role of MR Enterography in Assessment of Small Bowels Diseases: A Review Article

“…Commonly, agents such as 0.1% lowdensity barium suspension (NeuLumEX) and mannitol are used. Recent studies have identified pineapple juice as a potent medium for bowel expansion and enhancing image clarity, offering the advantage of minimal artefacts and lacking adverse reactions (Figure 1) [4] . ---------------------------------------------------------------------------------------------------------------------------------------------Imaging Sequences: MRE employs an extensive range of imaging sequences to obtain intricate visuals of the small intestine.…”

The Role of Black Tea and Pineapple Juice as Negative Oral Contrasts on Magnetic Resonance Cholangiopancreatography (Mrcp) Examination

“…Bahan yang dapat dimanfaatkan sebagai negative oral contrast harus dapat bertahan dalam waktu yang cukup lama di gastrointestinal tract dan memiliki kandungan unsur iron (Fe) dan Mangan (Mn) karena terdapat ikatan paramagnetic dari unsur tersebut yang bisa mengurangi waktu recovery (recovery time) pada T2 (dan T1) (AlShehri, 2015). Adapun bahan yang dapat berperan sebagai negative oral contrast antara lain adalah Gadopentetate Dimeglumine, Mannitol, atau Sorbitol, namun pada aplikasinya bahan-bahan tersebut memiliki kekurangan antara lain adalah adanya resiko alergi yang ditimbulkan oleh contrast agent tersebut, harga yang relatif mahal dan tingkat ketersediaan yang rendah untuk beberapa Negara (Chan et al, 2000, Elsayed et al, 2015. Berdasarkan literatur, contrast agent yang ideal digunakan dalam melakukan pemeriksaan medis pada manusia haruslah memenuhi persyaratan antara lain adalah dapat di toleransi, tersedia, dapat dengan mudah dipersiapkan, terdistribusi secara homogen pada gastrointestinal tract, tidak terserap pada sirkulasi sistemik, tidak menimbulkan artefak, dapat terekskresi dengan sempurna, meningkatkan nilai sensitivitas diagnostik, dan harga yang terjangkau serta tingkat keamanan yang tinggi.…”