To mitigate the conflict between ecological restoration and the pursuit of economic benefits in characteristic agriculture within plateau regions, this study proposes a theoretical framework for supervising plateau-characteristic agroecological security (PCAES). Initially, characteristic agriculture is conceptualized as an artificial ecosystem resulting from the complex interactions between the ecological environment and specific agricultural resources in a given plateau region; thus, PCAES is defined as a sustainable developmental state of plateau-characteristic agriculture that ensures a high-quality resource supply without compromising ecological integrity. Subsequently, a theoretical framework of PCAES is constructed by analyzing supervisory subjects, objects, and their interrelationships, followed by an in-depth study from three different perspectives. At the foundational level, the monitoring and evaluation mechanism focuses on gathering data regarding resource composition and environmental conditions to assess ecological security. At the intermediate level, the early warning and decision-making mechanism aims at estimating potential ecological security issues and then designing and selecting optimal measures. At a higher level, the control and assurance mechanism directs stakeholders toward compliance with ecological safety regulations via resource allocation and macro-policy interventions while ensuring effective system operation. This study holds significant implications for advancing green development initiatives, enhancing agricultural scientific innovation, and promoting sustainable practices in plateau agriculture.