2014
DOI: 10.4238/2014.may.30.7
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Effectiveness of olfactory ensheathing cell transplantation for treatment of spinal cord injury

Abstract: ABSTRACT. The aim of this study was to determine the effectiveness and safety of transplantation of olfactory ensheathing cells for functional repair of the spinal cord. An olfactory bulb was obtained from a 4-to 5-month-old aborted fetus, and it was digested into single olfactory ensheathing cells and then cultured and purified for 1 to 2 weeks. Under general anesthesia, these single-cell suspensions of olfactory ensheathing cells were injected into the corresponding spinal injury site with 0.45-mm-diameter i… Show more

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Cited by 25 publications
(13 citation statements)
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“…OEC can secrete neurotrophic factors, remyelinate damaged axons, survive and migrate within the nerve tissue and guide the axonal neurite outgrowth [ 17 ]. Regarding the availability of patient specific OEC, their neurotrophic characteristics and their safety and effectiveness for the treatment of nerve injuries [ 15 ] these cells may be great candidates for implantation to PNI to promote neurite extension, endogenous Schwann cell migration and finally better nerve regeneration [ 18 ]. In comparison with SCI, OEC have been underappreciated for PNI and just a few studies have addressed their incredible therapeutic potential [ 19 , 18 ].…”
Section: Backgroundsmentioning
confidence: 99%
“…OEC can secrete neurotrophic factors, remyelinate damaged axons, survive and migrate within the nerve tissue and guide the axonal neurite outgrowth [ 17 ]. Regarding the availability of patient specific OEC, their neurotrophic characteristics and their safety and effectiveness for the treatment of nerve injuries [ 15 ] these cells may be great candidates for implantation to PNI to promote neurite extension, endogenous Schwann cell migration and finally better nerve regeneration [ 18 ]. In comparison with SCI, OEC have been underappreciated for PNI and just a few studies have addressed their incredible therapeutic potential [ 19 , 18 ].…”
Section: Backgroundsmentioning
confidence: 99%
“…Cell therapy is thought to be a promising strategy for CNS repair over recent years. Neural stem cells (NSCs) and olfactory ensheathing cells (OECs) are two major types of cells used in a variety of CNS disease for both clinical application and animal models, including brain injury, spinal cord injury (SCI), Parkinsonian disease, and cognitive dysfunction (Srivastava et al, 2009;Ambasudhan et al, 2014;Rao et al, 2014;Wakeman et al, 2014). However, the sources of these two cells from hippocampus and olfactory bulb (OB) impede the progress of clinical application.…”
Section: Introductionmentioning
confidence: 97%
“…Physiological neural regeneration is not possible because of injured central nerve axons. Functional reconstruction after spinal cord injury has been a challenging clinical problem [4]. …”
Section: Introductionmentioning
confidence: 99%