Effectiveness of Omeprazole‐Amoxicillin‐Clarithromycin (OAC) Therapy for <i>Helicobacter pylori</i> Infection in a Japanese Population

Miwa, Hiroto; Ohkura, Ryuichi; Murai, Toshio; Nagahara, Akihito; Yamada, Tetsuya; Ogihara, Tatsuo; Watanabe, Sumio; Sato, Nobuhiro

doi:10.1046/j.1523-5378.1998.08041.x

Cited by 23 publications

(23 citation statements)

References 18 publications

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“…They have provided cure rates as high as 80% to 90% with few adverse effects. [1][2][3][4] However, the number of patients with treatment failure has begun to increase with the increased levels of treatment for this bacterium. Therefore, it is urgently necessary to establish a standard re-treatment regimen.…”

Section: Introductionmentioning

confidence: 99%

Second-line treatment for Helicobacter pylori infection in Japan: proton pump inhibitor-based amoxicillin and metronidazole regimen

et al. 2004

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Section: Introductionmentioning

confidence: 99%

Second-line treatment for Helicobacter pylori infection in Japan: proton pump inhibitor-based amoxicillin and metronidazole regimen

et al. 2004

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“…In addition, a multi-center study performed in France demonstrated a somewhat higher, although not significant, eradication rate with lowdose clarithromycin triple therapy compared with the conventional regimen [17] . In a study by Miwa H et al [15] using different doses of omeprazole-clarithromycin-amoxicillin, in their low-dose group of omeprazole 20 mg, amoxicillin 750 mg and clarithromycin 200 mg all b.i.d, the eradication rates by ITT and PP were 82.5% and 90% respectively. In our study, the eradication rate of low-dose regimen was 85% and 88% by ITT and PP analysis, respectively.…”

Section: Discussionmentioning

confidence: 98%

“…The treatments were well tolerated and associated with a high compliance rate. Many studies have compared different doses of clarithromycin in H pylori eradication, with contradictory results, but those that have evaluated clarithromycinamoxicillin combination in low-dose regimens for H pylori eradication are scarce [15] . Hp consensus groups have generally recommended a 500 mg b.i.d dosage of clarithromycin for H pylori eradication [7,8] .…”

Section: Discussionmentioning

confidence: 99%

“…As this regimen is costly for routine use in developing countries, dose reduction is an option to decrease its cost. There are limited studies that have evaluated the efficacy of both clarithromycin and amoxicillin in low-dose regimens in H pylori eradication with a PPI-based triple therapy [15][16][17][18][19] . Therefore, we tried to investigate the efficacy and tolerability of omeprazole-based triple therapy with high and low doses of clarithromycin and amoxicillin in H pylori eradication in Iranian population.…”

Section: Introductionmentioning

confidence: 99%

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Omeprazole-based triple therapy with low-versus high-dose of clarithromycin plus amoxicillin forH pylorieradication in Iranian population

Keshavarz

Bashiri²,

Rahbar³

2007

WJG

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AIM:To investigate the efficacy and tolerability of H pylori eradication in an omeprazole-based triple therapy with high-and low-dose of clarithromycin and amoxicillin. C-urea breath test 6 wk after the therapy. Standard questionnaires were administered to determine the compliance to treatment and possible adverse events of therapy. Data were subject to χ 2 to compare the eradication rates in the two groups. The significant level of 95% (P ≤ 0.05) was considered statistically different. METHODS: RESULTS:We found that the per-protocol eradication rate was 88% (68/77) in group A, and 89% (67/75) in group B. The intension-to-treat eradication rate was 85% (68/80) in group A and 83.75% (67/80) in group B. Overall adverse events were 26% in group A and 31% in group B. The adverse events were generally mild in nature and tolerated well in both groups with a compliance of 98% in group A vs 96% in group B. CONCLUSION:

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“…[8] This treatment regimen is known to be effective for eradication in 80-90% of cases, with few adverse effects. [9][10][11] However, there have been few reports about the efficacy and safety of eradication therapy for H. pylori in hemodialysis patients. [12,13] CAM is metabolized both in the liver and kidney, [14] while AMOX is metabolized mainly in the kidney.…”

Section: Introductionmentioning

confidence: 99%

Eradication ofHelicobacter pyloriin Hemodialysis Patients

et al. 2007

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Background. Helicobacter pylori (H. pylori) are a causative agent of digestive disease. Although a proton pump inhibitor combined with amoxicillin-clarithromycin is the accepted drug treatment for H. pylori eradication in Japan, there is no consensus treatment for hemodialysis patients. Study. Seventy-seven hemodialysis patients underwent upper digestive tract endoscopy. Biopsy specimens were taken, and histological findings, culture, and rapid urease tests were performed to confirm the presence of H. pylori. H. pylori-positive patients were then administered at random either a seven-day lansoprazole (60 mg a day)-amoxicillin (750 mg a day)-clarithromycin (400 mg a day) (LAC) regimen or a seven-day lansoprazole (60 mg a day)-clarithromycin (400 mg a day) (LC) regimen. The success of H. pylori eradication was determined from histological findings, culture, and rapid urease tests. Results. In 13 of 77 patients (13.6%), ulcers and/or ulcer scars were seen by endoscopy. Thirty-one patients (40.3%) were positive for H. pylori, and 20 patients among them were randomized to one of two regimens: one is seven-day LAC regimen (eleven patients) and the other is seven-day LC regimen (nine patients). Eradication was successful in nine of the eleven patients (72.7%) receiving the LAC regimen, but in only three of the nine patients (33.3%) who underwent the LC regimen. No serious adverse effects were observed with either regimen, and 95% of the patients reported complete compliance. Conclusion. A seven-day low dose LAC regimen is safe and effective and recommended for treatment of H. pylori infection in hemodialysis patients.

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Effectiveness of Omeprazole‐Amoxicillin‐Clarithromycin (OAC) Therapy for Helicobacter pylori Infection in a Japanese Population

Abstract: Two weeks PPI/AC therapy is highly effective for cure of H. pylori infection in the Japanese population. The low dose one month regimen and the one week OAC regimen were also effective in our patient population.

Cited by 23 publications

References 18 publications

Second-line treatment for Helicobacter pylori infection in Japan: proton pump inhibitor-based amoxicillin and metronidazole regimen

Second-line treatment for Helicobacter pylori infection in Japan: proton pump inhibitor-based amoxicillin and metronidazole regimen

Omeprazole-based triple therapy with low-versus high-dose of clarithromycin plus amoxicillin forH pylorieradication in Iranian population

Eradication ofHelicobacter pyloriin Hemodialysis Patients

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