Effectiveness of Oral Antiseptics on Tooth Biofilm: A Study in vivo

Mouchrek, José Carlos Elias; Nunes, Lívia Helena de Araújo Castro; Arruda, Cleidiane Silveira; Rizzi, Cláudia de Castro; Mouchrek, Adriana Quinzeiro E Silva; Tavarez, Rudys Rodolfo de Jesus; Tonetto, Mateus Rodrigues; Bandéca, Matheus Coêlho; Filho, Etevaldo Matos Maia

doi:10.5005/jp-journals-10024-1739

Cited by 14 publications

(13 citation statements)

References 22 publications

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“…They are broad-spectrum cationic biocides, which generally affect the microbial membrane integrity of both Gram-positive and Gram-negative bacteria 4 . These antiseptics are also commonly used as co-adjuvants in the treatment of periodontal diseases such as gingivitis and chronic and aggressive periodontitis 5 , as the clinical anti-plaque efficacy of CHX and CPC on oral supragingival and subgingival biofilms has been shown extensively 1,6,7 .…”

Section: Introductionmentioning

confidence: 99%

Development of antiseptic adaptation and cross-adapatation in selected oral pathogens in vitro

Verspecht

Herrero

Khodaparast

et al. 2019

Sci Rep

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There is evidence that pathogenic bacteria can adapt to antiseptics upon repeated exposure. More alarming is the concomitant increase in antibiotic resistance that has been described for some pathogens. Unfortunately, effects of adaptation and cross-adaptation are hardly known for oral pathogens, which are very frequently exposed to antiseptics. Therefore, this study aimed to determine the in vitro increase in minimum inhibitory concentrations (MICs) in oral pathogens after repeated exposure to chlorhexidine or cetylpyridinium chloride, to examine if (cross-)adaptation to antiseptics/antibiotics occurs, if (cross-)adaptation is reversible and what the potential underlying mechanisms are. When the pathogens were exposed to antiseptics, their MICs significantly increased. This increase was in general at least partially conserved after regrowth without antiseptics. Some of the adapted species also showed cross-adaptation, as shown by increased MICs of antibiotics and the other antiseptic. In most antiseptic-adapted bacteria, cell-surface hydrophobicity was increased and mass-spectrometry analysis revealed changes in expression of proteins involved in a wide range of functional domains. These in vitro data shows the adaptation and cross-adaptation of oral pathogens to antiseptics and antibiotics. This was related to changes in cell surface hydrophobicity and in expression of proteins involved in membrane transport, virulence, oxidative stress protection and metabolism.

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Section: Introductionmentioning

confidence: 99%

Development of antiseptic adaptation and cross-adapatation in selected oral pathogens in vitro

Verspecht

Herrero

Khodaparast

et al. 2019

Sci Rep

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“…Therefore, mechanical control of dental biofilm through routine oral hygiene is key to pathogen control and disease prevention [ 6 , 7 , 8 , 9 ]. Chemical plaque control with antibacterial mouthwashes can be an alternative to mechanical methods when they are ineffective [ 7 , 10 , 11 , 12 , 13 , 14 ]. Hence, the use of chemical and mechanical control is recommended synchronously to guarantee good oral hygiene and potentiate a good oral health state [ 7 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

“…Chlorhexidine (CHX), triclosan (TRC), cetylpyridinium chloride (CPC), and some essential oils (EOs) (eucalyptol, thymol, menthol, etc.) are among the active ingredients commonly found in mouthwash formulations [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

“…This form of pneumonia is the most common nosocomial infection in intensive care, affecting 10–30% of mechanically ventilated patients [ 42 , 43 ]. Moreover, both dental professionals and patients are at increased risk of cross-infection in clinical practice [ 12 , 17 , 20 , 22 , 44 ]. The main routes for the spread of most viral, bacterial and fungal infections in a dental setting are droplets, direct contact and air [ 45 , 46 ].…”

Section: Introductionmentioning

confidence: 99%

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Revisiting Oral Antiseptics, Microorganism Targets and Effectiveness

Garrido,

Lyra,

Rodrigues

et al. 2023

JPM

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A good oral health status is mostly dependent on good oral hygiene habits, which knowingly impacts systemic health. Although controversial, chemical oral antiseptics can be useful in adjunct use to mechanical dental plaque control techniques in the prevention and management of local and overall health and well-being. This review aims to revisit, gather and update evidence-based clinical indications for the use of the most popular oral antiseptics, considering different types, microorganism targets and effectiveness in order to establish updated clinical recommendations.

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“…Sus principales agentes patógenos son el Streptococcus mutans (S. mutans) y Porphyromonas gingivalis (P. gingivalis) (2,3) . Para mantener la salud de los tejidos bucales se requieren de cepillos dentales, dentífricos, hilo dental y antisépticos bucales (4)(5)(6) . El gluconato de clorhexidina (CHX) es la primera elección (7) , porque conjuga los efectos antibiopelícula/antibacteriano.…”

Section: Mensajes Clave Introducciónunclassified

Actividad antimicrobiana in vitro del camu camu (Myrciaria dubia) contra microorganismos orales: una revisión sistemática

Pardo-Aldave

Pareja-Vásquez

Guillén

et al. 2019

Rev Peru Med Exp Salud Publica

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Objetivos. Evaluar la actividad antimicrobiana de la Myrciaria dubia sobre microorganismos orales. Materiales y métodos. Se realizó una revisión sistemática de la literatura siguiendo las recomendaciones PRISMA mediante búsquedas en Pubmed, LILACS, SciELO, ProQuest, EBSCO y Google Scholar, de estudios publicados durante 2008 y 2018. Resultados. Se recopilaron 11 estudios, in vitro, todos los estudios evidenciaron actividad antimicrobiana positiva, principalmente por cada una de las partes de sus frutos, sobre grampositivos. Sin embargo, dicha actividad fue comparada con clorhexidina en solo dos estudios y en otro resultó ser mejor que un antibiótico. Se detectó un alto riesgo de sesgo en la mayoría de estudios. Los compuestos fenólicos incluidos polifenoles y acilfloroglucinoles fueron señalados como los responsables de su actividad. Conclusiones. Existe evidencia sobre la actividad antimicrobiana de M. dubia. Su estudio como antimicrobiano contra microorganismos orales es aún incipiente, pero se advierte un gran potencial debido a los fitoquímicos potentes que posee. Además, se necesita más estudios de calidad, que comparen su actividad versus antisépticos orales y sobre más microorganismos asociados a caries dental y enfermedad periodontal.

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Effectiveness of Oral Antiseptics on Tooth Biofilm: A Study in vivo

Abstract: The reduction in the plaque index during the period of evaluation was different between the types of mouth-wash. The mouthwash containing the active ingredient chlorhexidine was the most effective, followed by the essential oil, cetylpyridinium chloride, triclosan and H. virginiana.

Cited by 14 publications

References 22 publications

Development of antiseptic adaptation and cross-adapatation in selected oral pathogens in vitro

Development of antiseptic adaptation and cross-adapatation in selected oral pathogens in vitro

Revisiting Oral Antiseptics, Microorganism Targets and Effectiveness

Actividad antimicrobiana in vitro del camu camu (Myrciaria dubia) contra microorganismos orales: una revisión sistemática

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