Effectiveness of Penicillin Irrigation in Control of Infection in Sutured Lacerations

Lindsey, Douglas; Nava, C; Marti, Maria

doi:10.1097/00005373-198203000-00002

Cited by 33 publications

(10 citation statements)

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“…Although controversial, local deposition of antibiotics has been reported to be an effective means of reducing the risk of post operative infections (Lindsey et al . ; Beroza ). Local deposition of antibiotics is performed solely to reduce the amount of contaminating bacteria present when the incisions between the sterno‐ and omohyoid muscles are sutured and it is not probable that local deposition of antibiotics will prevent infection if continuous leakage of air and/or saliva is present.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, we used antibiotics routinely locally in the incision intraoperatively and systemically for 5 days post operatively compared with no local antibiotics and only 1-2 days of post operative systemic administration in the study by Boulton et al (1995). Although controversial, local deposition of antibiotics has been reported to be an effective means of reducing the risk of post operative infections (Lindsey et al 1982;Beroza 1994). Local deposition of antibiotics is performed solely to reduce the amount of contaminating bacteria present when the incisions between the sterno-and omohyoid muscles are sutured and it is not probable that local deposition of antibiotics will prevent infection if continuous leakage of air and/or saliva is present.…”

Section: Discussionmentioning

confidence: 99%

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Primary closure of equine laryngotomy incisions: Healing characteristics and complications of 180 cases

Lindegaard

Karlsson

Ekstrøm

et al. 2016

Equine Veterinary Education

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Summary The objective was to report healing characteristics and complications after primary closure of equine laryngotomies and analyse factors potentially associated with complications. This retrospective case series of the medical records of horses (n = 180) undergoing laryngoplasty and laryngotomy incision between January 1995 and June 2012 were reviewed. Horses with a laryngotomy incision closed in three layers for primary healing were included. Descriptive data on healing characteristics and complications of laryngotomy wounds were collected from the medical records and via follow‐up questionnaires sent to the owners. During hospitalisation 6.1% of the laryngotomy wounds became infected. In addition, 3.3% had oedema around the wound and 3.3% had subcutaneous emphysema after surgery. Neither oedema nor emphysema required additional treatment. No signs of respiratory distress, need of a tracheotomy or need for a reopening of the laryngotomy was observed in any horse. Infection of the laryngoplasty wound occurred in one horse. A total of 96 questionnaires were answered. Prolonged healing of the incision after discharge from the hospital was reported in four horses (4.2%). Laryngotomy infections were confined to the subcutaneous tissues; none led to complete dehiscence and all healed within 4 weeks. Regression analysis showed that closure of the skin with suture carried significantly higher odds of infection than skin staples (OR = 7.93 [95% CI: 2.55–24.67]; P = 0.032). Complications after primary closure of equine laryngotomy incisions are infrequent and considered of minimal severity and can be performed safely when paying careful attention to the closure of the cricothyroid membrane.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Primary closure of equine laryngotomy incisions: Healing characteristics and complications of 180 cases

Lindegaard

Karlsson

Ekstrøm

et al. 2016

Equine Veterinary Education

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“…The topical use of a variety of antibiotics has long been used effectively in treatment and prophylaxis of wound infection. 5,33,35 Moreover, in neurosurgical shunt operations the use of a local antibiotic injected directly into the shunt 34 Staphylococcus species are highly sensitive to vancomycin. Thus, the use of a local vancomycin wash into subcutaneous tissue is judicious in hardware implantation surgery.…”

Section: Discussionmentioning

confidence: 99%

Changing of the guard: reducing infection when replacing neural pacemakers

Pepper

Meliak

Akram

et al. 2017

JNS

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OBJECTIVE Infection of deep brain stimulation (DBS) hardware has a significant impact on patient morbidity. Previous experience suggests that infection rates appear to be higher after implantable pulse generator (IPG) replacement surgery than after the de novo DBS procedure. In this study the authors examine the effect of a change in practice during DBS IPG replacements at their institution. METHODS Starting in January 2012, patient screening for methicillin-resistant Staphylococcus aureus (MRSA) and, and where necessary, eradication was performed prior to elective DBS IPG change. Moreover, topical vancomycin was placed in the IPG pocket during surgery. The authors then prospectively examined the infection rate in patients undergoing DBS IPG replacement at their center over a 3-year period with at least 9 months of follow-up. RESULTS The total incidence of infection in this prospective consecutive series of 101 IPG replacement procedures was 0%, with a mean follow-up duration of 24 ± 11 months. This was significantly lower than the authors' previously published historical control group, prior to implementing the change in practice, where the infection rate for IPG replacement was 8.5% (8/94 procedures; p = 0.003). CONCLUSIONS This study suggests that a change in clinical practice can significantly lower infection rates in patients undergoing DBS IPG replacement. These simple measures can minimize unnecessary surgery, loss of benefit from chronic stimulation, and costly hardware replacement, further improving the cost efficacy of DBS therapies.

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“…In a controlled, double‐blind trial of 260 lacerations that required suture, Lindsey et al. [7] found that additional irrigation with penicillin‐containing solution was superior (p < 0.001) to irrigation with saline alone with respect to the prevention of infection, as estimated by a single observer.…”

Section: Antibiotic‐containing Solutions For the Prevention Of Infectmentioning

confidence: 99%

Irrigation with antibiotic-containing solutions for the prevention and treatment of infections

Falagas

Vergidis

2005

Clinical Microbiology and Infection

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Administration routes for antimicrobial agents used in clinical practice include the topical, inhaled, enteral and parenteral routes. An antibiotic administration route used frequently worldwide, although not well-studied, involves the irrigation of wounds with antibiotic-containing solutions for the prevention and treatment of infections. This review considers the data available from various experimental and clinical studies in order to provide an update on the use of antibiotic-containing solutions in modern clinical practice. Although irrigation with antibiotic-containing solutions has been suggested to be beneficial in the prevention or treatment of infections in several settings and patient populations, no firm, evidence-based recommendations can be made regarding its use until additional data from well-designed, randomised clinical trials become available. Current exceptions include empyema following lobectomy, or pneumonectomy and pyocystis (vesical empyema), since irrigation with solutions containing antimicrobial agents seems to be a crucial component of the management of these conditions.

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Effectiveness of Penicillin Irrigation in Control of Infection in Sutured Lacerations

Cited by 33 publications

References 0 publications

Primary closure of equine laryngotomy incisions: Healing characteristics and complications of 180 cases

Primary closure of equine laryngotomy incisions: Healing characteristics and complications of 180 cases

Changing of the guard: reducing infection when replacing neural pacemakers

Irrigation with antibiotic-containing solutions for the prevention and treatment of infections

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