Effectiveness of Percutaneous Ethanol Injection in Nodular Diseases of the Thyroid Gland: 10-Year Follow-Up

Espenbetova, Mayra; Amrenova, K; Zhumanbayeva, Zhanar; Zamanbekova, Zhanar; Yurkovskaya, Oksana; Shalgumbayeva, Gulnar; Dyussupova, Azhar; Telford, Onala; Glushkova, Natalya

doi:10.4158/ep-2018-0215

Cited by 4 publications

(5 citation statements)

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“…The final metaanalysis included 19 studies, consisting of eight two-arm parallel studies (four RCTs [10,11,13,31], two prospective cohort studies [6,32], and two retrospective cohort studies [8,9]), which compared EA with other types of non-surgical management, and 11 single-arm studies ( Fig. 1) [7,12,[33][34][35][36][37][38][39][40][41]. Of note, Verde et al [32] conducted a preliminary RCT followed by a prospective cohort, which was integrated into a larger cohort by pooling the VRRs at 1 month.…”

Section: Resultsmentioning

confidence: 99%

“…All the studies had a low risk of bias in the domain of selective outcome reporting, whereas most of them had an unclear risk of bias in the domain of blinding of outcome assessments. Six studies had a low risk of bias in the patient selection domain [ 6 – 9 , 35 , 38 ], while the others were given an unclear or high risk of bias due to an uncertain process of patient recruitment [ 12 , 33 , 39 , 41 ] and retrospective data collection [ 34 , 36 , 37 , 40 ] or selection of the intervention and control groups from different populations [ 32 ], respectively. One study had high risk of bias in the incomplete data domain due to a large number of dropout cases in long-term follow-up [ 7 ].…”

Section: Resultsmentioning

confidence: 99%

“…Low-grade fever was a rare side effect documented by Valcavi and Frasoldati [ 31 ], which spontaneously resolved within 2 to 3 days without medication. Dysphonia was the major complication reported in eight patients from six studies [ 11 , 13 , 31 , 34 , 38 , 40 ], with symptom duration ranging from a few minutes to 2 months. Two of the cases complicated by transient dysphonia reported by Guglielmi et al [ 34 ] occurred in the other parallel group consisting of solid nodules, rather than the cystic nodules.…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, the long-term efficacy of EA for cystic thyroid nodules is satisfactory, although long-term results were reported in just a few studies. The VRRs at 2, 3, 5, and 10 years of follow-up in different studies were 72.7%–91.9%, 73.2%–95.8%, 86.6%–98.5%, and 70.2%–100%, respectively [ 7 , 34 , 38 , 53 , 54 ]. The reported recurrence rates in thyroid cysts after EA were low (3.1%–18%), and also varied according to the criteria that were used [ 11 , 32 , 55 ].…”

Section: Discussionmentioning

confidence: 99%

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Efficacy of Ethanol Ablation for Benign Thyroid Cysts and Predominantly Cystic Nodules: A Systematic Review and Meta-Analysis

2021

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Background: Ultrasound-guided minimally invasive procedures are widely used to treat thyroid diseases. The objective of this study was to assess the efficacy and safety of ethanol ablation (EA) in comparison with other non-surgical options in the treatment of benign thyroid cystic nodules. Methods: We conducted a systematic search of studies on EA for thyroid cystic nodules, mainly in the Ovid-MEDLINE and Embase, Web of Science, and Cochrane databases. The standardized mean difference (SMD) of the volume reduction ratio (VRR) after EA versus other non-surgical treatments comprised the primary outcome, whereas the odds ratio (OR) of therapeutic success rates between the two groups comprised the secondary outcome. Results: The meta-analysis included 19 studies (four randomized controlled trials and 15 non-randomized studies) with 1,514 participants. The cumulative VRR of EA was 83.908% (95% confidence interval [CI], 79.358% to 88.457%). EA had a significantly higher pooled VRR (SMD, 0.381; 95% CI, 0.028 to 0.734; P=0.030), but not a significantly higher pooled therapeutic success rate (OR, 0.867; 95% CI, 0.132 to 5.689; P=0.880), than other forms of non-surgical management including radiofrequency ablation (RFA), polidocanol sclerotherapy, and simple aspiration with or without saline flush. However, the VRR and therapeutic success rate were not significantly different between EA and RFA. Major complications were recorded only in six patients (0.53%) with self-limiting dysphonia. Conclusion: The role of EA as the first-line treatment for benign thyroid cysts and predominantly cystic nodules is supported by its high effectiveness and good safety profile compared to other currently available non-surgical options.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Efficacy of Ethanol Ablation for Benign Thyroid Cysts and Predominantly Cystic Nodules: A Systematic Review and Meta-Analysis

2021

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“…Most of the population are descendants of individuals affected by the effects of the tests. A number of epidemiological studies on the health of the population and the risks of developing various neoplasms have been carried out in the region [28,29]. Data on contamination of the territory with trace elements also create prerequisites for aggravating the negative impact on the health of residents living in the region [30].…”

Section: Study Advantages and Limitationsmentioning

confidence: 99%

Preliminary Analysis Of Early And Late Radiation Responses In 3D Image-Guided Brachytherapy For Cervical Cancer

et al. 2022

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Rationale – The use of 3D image-guided brachytherapy (3D-IGBT) allows adequately optimizing the dose distribution to bring a target therapeutic dose to clinical target volume (CTV), thereby minimizing an impact on critical organs, while ensuring a decrease in the incidence and severity of radiation-caused complications. Use of 3D-IGBT also allows improving the quality of life in patients with cervical cancer. Objective – To conduct a preliminary analysis of the incidence of early and late radiation responses in 3D-IGBT of locally advanced cervical cancer (LACC). Materials and Methods – The objects of our study were female patients with stages IIB and IIIB of cervical squamous cell carcinoma, without confirmed metastases, preceding chemotherapy (CHT) and/or radiation therapy (RT), and surgical interventions in this localization, who underwent combined chemoradiotherapy during the study. Results – Statistically significant results were obtained when analyzing the incidence of late radiation responses. It is important to point out that when assessing early toxicity in the main group with 3D-IGBT, grade 3 responses were not diagnosed, while in the control group, they were observed in 4 (9.1%) women. For instance, the manifestation of grade 3 delayed radiation injuries in the rectum was diagnosed in 3 (6.8%) women in the control group, while in the main group, they were not detected. Grade 2 cystitis was observed in a smaller number of women in the group with 3D-IGBT, compared with the control group (9.1% vs. 13.6%, p<0.05). Grade 3 delayed radiation responses in the bladder were diagnosed in 4 (9.1%) women in the control group, whereas among the patients of the main group with 3D-IGBT, they were not recorded at all (p <0.05). Grade II reactions in the vaginal mucosa and cervix were diagnosed more often in the control group (16.7% vs. 13.6%, p<0.05). Conclusion – Hence, the method we have used to optimize the treatment of LACC by means of 3D planning in accordance with toxicity criteria exhibited a definite advantage, compared with RT with 2D planning. Based on the results of our research, we concluded that optimization of RT for LACC using 3D-IGBT created clinically favorable conditions for effective therapy: it reduced the risk of displacement of the applicators and decreased an impact on the patient via reducing the total radiation doses and incidence of severe early and late toxic effects, providing good outcomes of local control regardless of tumor size and clinical stage.

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Swellings of the Tracheal Region

Sakr

2024

Midline Neck Swellings

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Effectiveness of Percutaneous Ethanol Injection in Nodular Diseases of the Thyroid Gland: 10-Year Follow-Up

Cited by 4 publications

References 30 publications

Efficacy of Ethanol Ablation for Benign Thyroid Cysts and Predominantly Cystic Nodules: A Systematic Review and Meta-Analysis

Efficacy of Ethanol Ablation for Benign Thyroid Cysts and Predominantly Cystic Nodules: A Systematic Review and Meta-Analysis

Preliminary Analysis Of Early And Late Radiation Responses In 3D Image-Guided Brachytherapy For Cervical Cancer

Swellings of the Tracheal Region

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