Effectiveness of Perindopril/Indapamide Single-Pill Combination in Uncontrolled Patients with Hypertension: A Pooled Analysis of the FORTISSIMO, FORSAGE, ACES and PICASSO Observational Studies

Beneficial Effects of a Perindopril/Indapamide Single-Pill Combination in Hypertensive Patients with Diabetes and/or Obesity or Metabolic Syndrome: A Post Hoc Pooled Analysis of Four Observational Studies

“…The methodology for this subgroup pooled analysis has been fully described elsewhere [26] [34,35]) were integrated into a single database. The four studies had similar designs, study endpoints (office sitting SBP/ DBP), time points (1-and 3-month visits) and reported information.…”

“…In the present analysis, we investigated the efficacy and safety of a Per/Ind SPC in these difficult-to-treat subgroups of patients, using pooled data from four similar, large observational studies conducted in Eastern Europe [26]. The Per/Ind SPC provides an optimised ratio of two recommended major drug classes of antihypertensive agents, which in addition to providing reliable BP reduction, have cardioprotective properties that could be valuable in patients with hypertension and metabolic abnormalities [27,28].…”

“…The Per/Ind SPC provides an optimised ratio of two recommended major drug classes of antihypertensive agents, which in addition to providing reliable BP reduction, have cardioprotective properties that could be valuable in patients with hypertension and metabolic abnormalities [27,28]. The results of the overall population in this pooled analysis as well as the response of patients with isolated systolic hypertension and by age class and gender are presented separately [26]. Data from this pooled analysis have previously been presented at the meeting of the International Society of Hypertension in 2018 and published as two abstracts: Dézsi and colleagues reported the results in patients with obesity and Farsang for patients with T2DM [29,30].…”

“…The results of the overall population in this pooled analysis as well as the response of patients with isolated systolic hypertension and by age class and gender are presented separately [26]. Data from this pooled analysis have previously been presented at the meeting of the International Society of Hypertension in 2018 and published as two abstracts: Dézsi and colleagues reported the results in patients with obesity and Farsang for patients with T2DM [29,30].…”

The Application of Combined Preparations With Constant Doses of Antihypertensive Drugs as the Initial Tactics of Treatment at High Blood Pressure Level: Proven Facts and Expert’s Opinion

“…наблюдения сопровождалось статистически значимым снижением систолического и диастолического АД на 30 и 14 мм рт. соответственно (р<0,001), и позволило достичь целевого уровня АД у 70% пациентов[48].В то же время, у пациента с повышенной жесткостью артерий и/или вазоконстрикцией начальная терапия должна включать сочетанный прием блокатора РААС с АК или таким тиазидоподобным диуретиком, как индапамид.В качестве второго этапа при неэффективности ранее назначенной АГТ может быть рекомендован переход к трехкомпонентной комбинированной АГТ (преимущественно в виде ТОТ), т.е., переход на сочетанный прием блокатора РААС, АК и диуретика. мес.…”