Effectiveness of Physical Activity Interventions on Cognition, Neuropsychiatric Symptoms, and Quality of Life of Alzheimer’s Disease: An Update of a Systematic Review and Meta-Analysis

Liang, Yajing; Su, Qingwen; Sheng, Zhiren; Weng, Qiuyan; Niu, Yanfang; Zhou, Huixing; Liu, Chunbo

doi:10.3389/fnagi.2022.830824

Cited by 15 publications

(6 citation statements)

References 39 publications

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“…For example, in 2020, Eikelboom et al found that early and accurate identification of neuropsychiatric symptoms in persons with dementia may improve quality of life [ 25 ]. In a meta-analysis, Liang showed in 2022 that planned and professional physical activity has a positive effect on improving neuropsychiatric symptoms and the quality of life of individuals with Alzheimer’s disease [ 26 ]. Identifying neuropsychiatric symptoms in hospitalized patients is the first step in implementing appropriate interventions that may improve the quality of life of geriatric persons with NPS.…”

Section: Discussionmentioning

confidence: 99%

Neuropsychiatric Symptoms as Indicators of Fall Risk in Geriatric Inpatients

et al. 2023

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Background and Objectives: It is well established that patients with cognitive impairment are at a higher risk of falls. However, the impact of coexisting neuropsychiatric symptoms on the overall risk of falls in hospitalized geriatric individuals with and without dementia has not been extensively studied. This cross-sectional study will assess the association between neuropsychiatric symptoms and fall risk in geriatric individuals analyzed by sex. Materials and Methods: A total of 234 patients, both with and without dementia, admitted to the geriatric ward at Leszek Giec Upper-Silesian Medical Centre of the Silesian Medical University in Katowice, Poland, between January 2019 and January 2020 were included in this study. The Neuropsychiatric Inventory–Questionnaire was used to assess the presence of neuropsychiatric symptoms. Increased fall risk was defined by Berg scores of ≤40. Results: The mean age of the study group was 80.7 ± 6.6, and women accounted for 62.8% of the study population. Apathy was the most common neuropsychiatric symptom, affecting 58.1% of patients, and it was the most common symptom among people with dementia, affecting 67.80% of patients. The receiver operating characteristics curve analysis revealed that a high fall risk was significantly associated with the total number of neuropsychiatric symptoms (≥4) and the total intensity of these symptoms (≥6). For women, high fall risk was associated with three or more neuropsychiatric symptoms and a total neuropsychiatric symptom intensity score of at least 6. For men, the association of high fall risk with the total number of NPS was not significant; a total NPS intensity score of 10 or more was associated with high fall risk. Multivariate logistic regression analysis identified associations with fall risk for hallucinations. Conclusions: Our results suggest that the presence of neuropsychiatric symptoms, particularly hallucinations is associated with an increased risk of falls in geriatric inpatients. In addition, the cumulative total of NPS and their cumulative intensity are both independently associated with an increased risk of falls. These results suggest that fall prevention strategies should include the management of neuropsychiatric symptoms in hospitalized geriatric individuals.

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Section: Discussionmentioning

confidence: 99%

Neuropsychiatric Symptoms as Indicators of Fall Risk in Geriatric Inpatients

et al. 2023

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“…More precisely, it is thought that "short-term (2-5 months) physical activity interventions" would be a reasonable formula to favorably address the overall QOL in AD patients based on improvements in cognition and neuropsychiatric impairments. However, regarding their effectiveness, no objective distinction has been found between the different types of interventions [126] or the related outcomes in control groups receiving common care [127]. There are also rather conflicting opinions in the literature regarding the effects of physical exercise on mental activity in AD [13].…”

Section: Exercise/physical Activitymentioning

confidence: 99%

Topical Cellular/Tissue and Molecular Aspects Regarding Nonpharmacological Interventions in Alzheimer’s Disease—A Systematic Review

Aurelian,

Ciobanu,

Cărare

et al. 2023

IJMS

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One of the most complex and challenging developments at the beginning of the third millennium is the alarming increase in demographic aging, mainly—but not exclusively—affecting developed countries. This reality results in one of the harsh medical, social, and economic consequences: the continuously increasing number of people with dementia, including Alzheimer’s disease (AD), which accounts for up to 80% of all such types of pathology. Its large and progressive disabling potential, which eventually leads to death, therefore represents an important public health matter, especially because there is no known cure for this disease. Consequently, periodic reappraisals of different therapeutic possibilities are necessary. For this purpose, we conducted this systematic literature review investigating nonpharmacological interventions for AD, including their currently known cellular and molecular action bases. This endeavor was based on the PRISMA method, by which we selected 116 eligible articles published during the last year. Because of the unfortunate lack of effective treatments for AD, it is necessary to enhance efforts toward identifying and improving various therapeutic and rehabilitative approaches, as well as related prophylactic measures.

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“…The second important element of the CGA is assessing the mental state of the elderly. Even though the definitions of concepts are already in place, due to cultural diversity, individual feelings and the uncharted areas of the human mind, it is difficult to unequivocally define the boundary between well-being and mental abnormality, which is particularly relevant in case of the elderly, whose mental state has a significant impact on their quality of life [9,10]. The ageing process is characterised by a continuous progression of body function loss, which is reflected in the mood of the elderly.…”

Section: Introductionmentioning

confidence: 99%

Assessment of functional capacity of the elderly

Wróblewska¹,

Chmielewski²,

Florek-Łuszczki³

et al. 2023

Ann Agric Environ Med.

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Introduction and Objective.Ageing is a continuous, progressive process of functional reserve loss. Physical fitness and mental state have a significant impact on the functionality level of the elderly population. Assessing the degree elderly people's of independence regarding self-care is an important aspect of the Comprehensive Geriatric Assessment (CGA). The aim of the study was to assess the functional capacity of people over 65 years of age. Materials and method. The study involved 312 patients in hospital wards across Lower Silesia, south-west Poland. The criteria for participation were as follows: providing informed consent to participate in the study, intellectual capacity to be interviewed, and age over 65. The study applied the diagnostic survey method, together with the use of the VAS, Barthel, IADL and GDS scales. Results. Among the respondents, 59.94% were in a moderately severe condition according to the Barthel scale, average IADL score -20.56 points; according to the GDS scale, 58.97% had no symptoms of depression. Respondents suffered from multiple chronic diseases, the most common of which were hypertension (71.47%); they also reported some medical issues, mainly back pain (47.44). Assessment of the correlation of the Barthel and GDS scales, as well as the IADL and GDS, revealed a significant and negative correlation at -0.49 and -0.50. Assessment of the correlation between the number of diseases and the Barthel scale was -0.49, the number of symptoms and the Barthel scale -0.4; pain severity and the Barthel scale -0.41, number of diseases and IADL -0.58, and number of symptoms and IADL -0.52. Conclusions. The greater the seniors' independence regarding instrumental activities of daily living, the weaker the symptoms of depression. Multimorbidity and experiencing pain impaired independence among the elderly.

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Effectiveness of Physical Activity Interventions on Cognition, Neuropsychiatric Symptoms, and Quality of Life of Alzheimer’s Disease: An Update of a Systematic Review and Meta-Analysis

Cited by 15 publications

References 39 publications

Neuropsychiatric Symptoms as Indicators of Fall Risk in Geriatric Inpatients

Neuropsychiatric Symptoms as Indicators of Fall Risk in Geriatric Inpatients

Topical Cellular/Tissue and Molecular Aspects Regarding Nonpharmacological Interventions in Alzheimer’s Disease—A Systematic Review

Assessment of functional capacity of the elderly

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