Effectiveness of platelet rich fibrin alone or in combination with bone grafts in the treatment of infrabony defects: Systematic review and metanalysis

Theodosaki, Astero-Maria; Filippou, Sofia; Kazantzidis, Georgios; Doufexi, Aikaterini-Elisavet

doi:10.1016/j.hsr.2022.100066

Cited by 2 publications

(4 citation statements)

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“…8,9 Kelebihan dari material ini adalah pelepasan berbagai growth factors setidaknya selama 7 hari pada area yang dirawat, sehingga dapat menstimulasi proliferasi sel dan angiogenesis, mendukung proses penyembuhan dan regenerasi periodontal. 10 Platelet-rich Fibrin (PRF) telah menunjukkan manfaat yang cukup baik dalam bedah periodontal jika digunakan sebagai membran atau dicampur dengan bahan bone graft. 11 Zhou dkk., dalam tinjauan sistematisnya yang membahas tentang efek tambahan dari platelet-rich plasma (PRP), PRF, enamel matrix derivative (EMD), dan amnion membrane (AM) yang dikombinasikan dengan bone graft pada perawatan defek intraboni menyatakan bahwa PRF memberikan efek tambahan yang paling signifikan pada penyembuhan jaringan lunak, efektif sebagai adjunctive dalam perawatan regeneratif periodontal.…”

Section: American Academy Of Periodontology (Aap) Danunclassified

“…12 Platelet-rich fibrin (PRF) dapat meningkatkan sifat biologis bone graft ketika dicampur dengan bahan tersebut, menghasilkan integrasi yang lebih baik dengan jaringan di sekitarnya dan dukungan yang lebih baik untuk regenerasi jaringan periodontal. 10,11 Platelet-rich fibrin (PRF) sebagai membran menyediakan biological scafold yang banyak mengandung growth factors, sehingga dapat meningkatkan regenerasi jaringan dan penyembuhan luka pada defek periodontal. Bahan utama PRF yang diambil dari darah pasien itu sendiri juga membuatnya bersifat autologus dan mengurangi risiko reaksi kekebalan atau penularan penyakit, sehingga memberikan manfaat lebih dalam bedah periodontal.…”

Section: American Academy Of Periodontology (Aap) Danunclassified

“…menyatakan bahwa kombinasi PRF dengan material bone graft dapat meningkatkan proses penyembuhan tulang pada perawatan defek intraboni. 10 Studi klinis dari Liu dkk., yang mengevaluasi efektivitas penggunaan GTR bersama dengan bone graft dan PRF pada defek intraboni menyatakan bahwa kombinasi ini memberikan hasil klinis yang lebih baik bila dibandingkan dengan kombinasi GTR dan bone graft saja. 15 Tujuan dari laporan kasus ini adalah untuk mengevaluasi efektivitas kombinasi PRF dengan material/teknik regeneratif lainnya dalam perawatan defek intraboni pada dua kasus periodontitis lanjut (stage III/IV).…”

Section: American Academy Of Periodontology (Aap) Danunclassified

“…Platelet-rich fibrin dikombinasikan dengan material bone graft memiliki kemampuan untuk meningkatkan efek regeneratif pada defek intraboni. 10 Penggunaan kombinasi PRF dengan bone graft memudahkan manipulasi dan aplikasi ke daerah bedah. Tujuan penggunaan PRF sebagai campuran bone graft maupun sebagai membran adalah untuk melepas growth factors pada fase awal penyembuhan.…”

Section: Pembahasanunclassified

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Combination of Platelet-rich Fibrin (PRF) in Advanced Periodontitis Stage Treatment

Harsas,

Tadjoedin,

Sulijaya

et al. 2023

J Indones Dent Assoc

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Introduction: The treatment of advanced periodontitis has been a challenge for clinicians. Platelet-rich fibrin (PRF) is a second-generation platelet concentrate that contains various growth factorss and cytokines that promote tissue regeneration. The use of PRF in combination with other regenerative materials and techniques has been shown to be effective in the treatment of intrabony defects. This case series aims to evaluate the efficacy of PRF combinations in the regenerative treatment of patients with advanced periodontitis. Case report: Two patients diagnosed with advanced periodontitis (stage III/IV grade C) were selected for this study. After the completion of periodontal initial therapy, there were still pockets with a probing depth ≥ 5 mm (5–10 mm). Therefore, surgical interventions were planned. The first case used the combination of PRF with bone graft and guided tissue regeneration (GTR), while open flap debridement (OFD) with the addition of PRF and bone graft to create sticky bone was done in the second case. Three to five months of follow-up showed favorable outcomes, as evidenced by reductions in probing depth (PD), gains in clinical attachment level, and filling of bone defects, as well as improvements in patient comfort and rapid wound healing. Conclusion: The combination of PRF with grafting material and/or GTR has been shown to be a beneficial therapeutic approach for periodontal regenerative therapy. Platelet-rich fibrin in periodontal surgery may accelerate the tissue healing process.

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Section: American Academy Of Periodontology (Aap) Danunclassified

Section: Pembahasanunclassified

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Combination of Platelet-rich Fibrin (PRF) in Advanced Periodontitis Stage Treatment

Harsas,

Tadjoedin,

Sulijaya

et al. 2023

J Indones Dent Assoc

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Navigating the combinations of platelet-rich fibrin with biomaterials used in maxillofacial surgery

Ieviņa,

Dubņika

2024

Front. Bioeng. Biotechnol.

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Platelet-rich fibrin (PRF) is a protein matrix with growth factors and immune cells extracted from venous blood via centrifugation. Previous studies proved it a beneficial biomaterial for bone and soft tissue regeneration in dental surgeries. Researchers have combined PRF with a wide range of biomaterials for composite preparation as it is biocompatible and easily acquirable. The results of the studies are difficult to compare due to varied research methods and the fact that researchers focus more on the PRF preparation protocol and less on the interaction of PRF with the chosen material. Here, the literature from 2013 to 2024 is reviewed to help surgeons and researchers navigate the field of commonly used biomaterials in maxillofacial surgeries (calcium phosphate bone grafts, polymers, metal nanoparticles, and novel composites) and their combinations with PRF. The aim is to help the readers select a composite that suits their planned research or medical case. Overall, PRF combined with bone graft materials shows potential for enhancing bone regeneration both in vivo and in vitro. Still, results vary across studies, necessitating standardized protocols and extensive clinical trials. Overviewed methods showed that the biological and mechanical properties of the PRF and material composites can be altered depending on the PRF preparation and incorporation process.

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Effectiveness of platelet rich fibrin alone or in combination with bone grafts in the treatment of infrabony defects: Systematic review and metanalysis

Cited by 2 publications

References 58 publications

Combination of Platelet-rich Fibrin (PRF) in Advanced Periodontitis Stage Treatment

Combination of Platelet-rich Fibrin (PRF) in Advanced Periodontitis Stage Treatment

Navigating the combinations of platelet-rich fibrin with biomaterials used in maxillofacial surgery

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