Effectiveness of platelet‐rich plasma therapy in wound healing of pilonidal sinus surgery: A comprehensive systematic review and meta‐analysis

Mostafaei, Shayan; Norooznezhad, Fatemeh; Mohammadi, Saeed; Norooznezhad, Amir Hossein

doi:10.1111/wrr.12597

Cited by 33 publications

(21 citation statements)

References 23 publications

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“…In the first stage of screening titles and abstracts, 79 references were selected. Full texts were scrutinised against the inclusion and exclusion criteria, with a final inclusion of 29 SRs (Figure ) . Reasons for exclusion of studies at the second stage are presented by topic and clinical indication in Files …”

Section: Resultsmentioning

confidence: 99%

Efficacy of platelet‐rich plasma for non‐transfusion use: Overview of systematic reviews

2019

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Platelet-rich plasma (PRP) is a blood component with a supraphysiologic concentration of platelets, usually obtained from the processing of autologous blood by different techniques, such as centrifugation and filtering. Despite the fact that strict recommendations on the most adequate techniques that should be employed for the production of PRP are still lacking, it is logical to assume that the type of method used for blood processing may determine the resulting concentration of platelet and other components, possibly impacting on its therapeutic potential. 1 The physiological rationale of the non-transfusion use of PRP relies on the high concentration of growth factors contained in platelets, such as the platelet derived-growth factor, the vascular endothelial growth factor and the fibroblast growth factor. 2 Several biological functions are attributed to these growth factors, including the proliferation of epithelial and mesenchymal cells, the stimulation of myoblasts and fibroblasts and angiogenesis. 3-5 Abstract Introduction: Platelet-rich plasma (PRP) is a blood component therapy with a supraphysiological concentration of platelets derived from allogenic or, more commonly, autologous blood. PRP has been used in different non-transfusion indications because of its role in the promotion of tissue repair and healing, in fields such as Traumatology, Dermatology and Dentistry.Objective: To provide a synthesis of the efficacy of PRP for different clinical situations. Methods: Systematic searches were carried out in MEDLINE, Embase, CochraneLibrary and LILACS in July 2018 to identify systematic reviews (SRs) of randomized clinical trials (RCTs) focusing on PRP for non-transfusion use. Two authors independently screened all retrieved references in two stages (titles and abstracts at a first stage and full texts at a second stage). The methodological quality of SRs that met the eligibility criteria was appraised by AMSTAR 2. Conclusions were based on the most recent SRs with highest quality. Results:One thousand two hundred and forty references were retrieved. After checking the inclusion criteria, 29 SRs of RCTs related to three different fields (wound care, Orthopedics and Dentistry) were included. The results suggest the benefit of PRP for different clinical situations, such as diabetic wounds, acute lesions of musculoskeletal system, rotator cuff lesions, tendinopathies, knee and hip osteoarthritis, total knee arthroplasty, allogenic bone graft for dental implants and periodontal intrabony defects. Conclusion:There is low to moderate quality evidence supporting the efficacy of PRP for specific clinical situations. The low quality of the evidence limits the certainty of these findings. Well-planned and well-conducted RCTs are still needed to further assess the efficacy of PRP.

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Section: Resultsmentioning

confidence: 99%

Efficacy of platelet‐rich plasma for non‐transfusion use: Overview of systematic reviews

2019

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“…Its use as an adjunct in the treatment of pilonidal sinus disease has been evaluated in a meta-analysis in 2017, which included 4 RCTs in surgery with secondary intention healing comparing PRP with the control group (classic dressings). 43 The healing time was found to be significantly shorter in the intervention group (Pooled effect size 0.642, 95% CI 0.485-0.798; P < 0.001), with a mean time to healing of 27.1 days in the PRP group compared with 43.0 days in the control group. The pooled effect size for time to return to work was 0.703 (95% CI 0.539-0.867), with a difference of 9.83 days shorter in the PRP group.…”

Section: Platelet-rich Plasmamentioning

confidence: 89%

“…Platelet‐rich plasma (PRP) is a product described to attempt to accelerate wound healing because of the release of several angiogenic factors upon degradation (vascular endothelial growth factor, insulin‐like growth factor, platelet‐derived angiogenesis factor, and platelet‐derived growth factor). Its use as an adjunct in the treatment of pilonidal sinus disease has been evaluated in a meta‐analysis in 2017, which included 4 RCTs in surgery with secondary intention healing comparing PRP with the control group (classic dressings) . The healing time was found to be significantly shorter in the intervention group (Pooled effect size 0.642, 95% CI 0.485‐0.798; P < 0.001), with a mean time to healing of 27.1 days in the PRP group compared with 43.0 days in the control group.…”

Section: Adjuncts To Surgerymentioning

confidence: 99%

Management of sacrococcygeal pilonidal sinus disease

Harries

Alqallaf

Torkington

et al. 2018

International Wound Journal

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The ideal treatment for patients who suffer from pilonidal sinus disease should lead to a cure with a rapid recovery period allowing a return to normal daily activities, with a low level of associated morbidity. A variety of different surgical techniques have been described for the primary treatment of pilonidal sinus disease and current practice remains variable and contentious. Whilst some management options have improved outcomes for some patients, the complications of surgery, particularly related to wound healing, often remain worse than the primary disease. This clinical review aims to provide an update on the management options to guide clinicians involved in the care of patients who suffer from sacrococcygeal pilonidal sinus disease.

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“…“Platelet concentrates” (PCs) is a generic term for different products enriched in platelets . Over the past decade, PCs have been used widely in the regeneration and repair of tissue for wound healing, bone fractures, osteoarthritis, skin rejuvenation, and hair growth . However, their application is confusing and the classification of terminologies for PCs is lacking.…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, autologous PRP derivatives have been used widely in dermatology, orthopedics, sports medicine, oral/maxillofacial surgery, cardiac surgery, gynecology, ophthalmology, cosmetic surgery, plastic, and reconstructive surgery . However, several studies have reported that PRP has no proven effect .…”

mentioning

confidence: 99%

Application of standardized platelet‐rich plasma in elderly patients with complex wounds

Tian

Cheng

Chen

et al. 2019

Wound Repair Regeneration

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In recent years, autologous platelet-rich plasma (PRP) derivatives have been used widely in the regeneration and repair of tissue, but a standard definition and preparation method for PRP are lacking. We developed a standardized method using platelet indices as quality-control indicators for PRP preparation. Twenty-one elderly patients (9 males, 12 females) with complex wounds were treated with standardized platelet-rich plasma (S-PRP). The platelet count in PRP after the second centrifugation was 1,069-1,436 × 10 9 /L. We adjusted the platelet concentration in PRP after a second centrifugation to 1,000 × 10 9 /L according to a formula using platelet-poor plasma (PPP). The standardized preparation method that we developed gave S-PRP with a relatively uniform platelet concentration. The wounds of 21 patients showed accelerated healing after S-PRP treatment, and there were no obvious side effects during treatment. These data suggest that our preparation method of S-PRP, using platelet indices as quality-control indicators with platelet count of 1,000 × 10 9 /L could be used for the treatment of complex wounds in the elderly. The preparation method of S-PRP proposed in the present study may be a simple and effective method of PRP quality control.

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Effectiveness of platelet‐rich plasma therapy in wound healing of pilonidal sinus surgery: A comprehensive systematic review and meta‐analysis

Cited by 33 publications

References 23 publications

Efficacy of platelet‐rich plasma for non‐transfusion use: Overview of systematic reviews

Efficacy of platelet‐rich plasma for non‐transfusion use: Overview of systematic reviews

Management of sacrococcygeal pilonidal sinus disease

Application of standardized platelet‐rich plasma in elderly patients with complex wounds

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