Effectiveness of Pre-Transfusion Medication in Preventing Platelet Transfusion Reaction

Watanabe, Junichi; Sato, Ken; Horiuchi, Toshikatsu; Ito, Kayo; Iwanaga, Sachiko; Sakaguchi, Takeshi; Kato, Shingo; Hikota, Reina; Maekawa, Taira; Yamamura, Takeshi; Kobayashi, Ayako; Osawa, Yukiko; Kobayashi, Shinichi; Tsuji, Akira; Kimura, Fumihiko

doi:10.3925/jjtc.61.8

Cited by 4 publications

(1 citation statement)

References 19 publications

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“…There are some reports that prophylactic administration and use of washed blood components are effective for prevention of allergic transfusion reactions. 13,14 Because history of adverse events is one of the risk factors for severe transfusion-related disease for patients who had recurrent adverse events, even with mild symptoms, these treatments should be enforced to prevent severe transfusion-related diseases.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Acute Transfusion Reactions and Their Occurrence Times

et al. 2018

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Acute transfusion reactions (ATRs) are significantly relevant to the morbidity and mortality of patients. ATRs are mostly not severe and rarely cause severe conditions, including anaphylactic shock. The aim of this study was to clarify the frequency of ATRs and the time of event occurrence. A total of 18,745 transfusions were administered to 11,718 patients during a 3-year period. Adverse reactions including at least one sign or symptom were collected through a report system in 143 of 2,478 (5.7%) platelet concentrate transfusions, 105 of 6,629 (1.6%) red blood cell component transfusions and 51 of 2,307 (2.2%) fresh frozen plasma transfusions. Allergic signs and symptoms accounted for 70% of all adverse events. Severe signs and symptoms were observed in 7.1% of patients. These events appeared significantly earlier than those of non-severe signs and symptoms (median time 20 min vs 100 min, P < 0.05). For patients who have had repetitive transfusion-associated adverse events, preventive treatments for adverse events should be proactively promoted.

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Section: Discussionmentioning

confidence: 99%