Effectiveness of probiotics in apical periodontitis progression: A scoping review and implications for research

Abstract

To synthesise the current knowledge on the effects of probiotics in apical periodontitis progression by a scoping review of animal and human studies. Reporting was based on Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) Extension for Scoping Reviews. The literature search and screening was performed on PubMed and Scopus databases by two independent reviewers selecting human and animal studies that evaluated the effectiveness of probiotics in reducing the severity of apical periodontitis. Two animal studies with 3 publications met the eligibility criteria for qualitative synthesis. The most common probiotics were Lactobacillus rhamnosus and Lactobacillus acidophilus orally administered for gavage in Wistar rats with induced apical periodontitis. Overall, probiotics significantly reduced inflammation and bone resorption with an improvement in the apical periodontitis progression. Although results in animal studies are promising, the use of probiotics in apical periodontitis progression requires caution due to the insufficient available evidence.

Antimicrobial Activity of Antibacterial Sutures in Oral Surgery: A Scoping Review

“…A scoping review is a methodological approach to define the current boundaries of a large and recent topic and provide useful indications for future research. 34 , 35 , 36 The antibacterial efficacy of sutures coated with antibacterial material is a topic of clinical interest in dentistry. Accordingly, the primary purpose of this scoping review was to identify the currently available studies assessing the antimicrobial activity of antimicrobial-coated sutures in oral surgery and the major limitations of the current research.…”