2021
DOI: 10.1007/s00404-020-05939-y
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Effectiveness of progesterone-primed ovarian stimulation in assisted reproductive technology: a systematic review and meta-analysis

Abstract: Purpose Progestin-primed ovarian stimulation (PPOS) is a new ovarian stimulation protocol that has been used over the last decade to enhance reproductive function. The purpose of this study is to evaluate whether PPOS is as effective as conventional protocols (without GnRHa downregulation). Method Search terms included “medroxyprogesterone”, “dydrogesterone”, “progestin-primed ovarian stimulation”, “PPOS”, “oocyte retrieval”, “in vitro fertilization”, “IVF… Show more

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Cited by 32 publications
(15 citation statements)
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“…In the current study, similar oocyte yields, metaphase II oocyte numbers, implantation rates, and clinical pregnancy rates were obtained in the PPOS and GnRH-ant groups. Several studies have also noted similar embryonic and pregnancy outcomes (e.g., oocyte and embryo quality) for PPOS and ovarian stimulation protocols other than GnRH-ant [19,20]. Moreover, there have been no differences in miscarriage rates or the euploidy rates of blastocysts between PPOS and GnRH-ant protocols [21].…”
Section: Discussionmentioning
confidence: 84%
“…In the current study, similar oocyte yields, metaphase II oocyte numbers, implantation rates, and clinical pregnancy rates were obtained in the PPOS and GnRH-ant groups. Several studies have also noted similar embryonic and pregnancy outcomes (e.g., oocyte and embryo quality) for PPOS and ovarian stimulation protocols other than GnRH-ant [19,20]. Moreover, there have been no differences in miscarriage rates or the euploidy rates of blastocysts between PPOS and GnRH-ant protocols [21].…”
Section: Discussionmentioning
confidence: 84%
“…Results were comparable in terms of the number of oocytes retrieved, viable embryo rate per oocyte retrieved and no patients experienced a premature LH surge [20]. Moreover, a recent meta-analysis that included 3565 cycles, revealed that PPOS is a safe option as a protocol for infertile patients [21]. There were no differences in clinical pregnancy rates and live birth rates, and the rate of OHSS was lower in the PPOS protocol [21].…”
Section: Prevention Of a Spontaneous Lh Surgementioning
confidence: 92%
“…Moreover, a recent meta-analysis that included 3565 cycles, revealed that PPOS is a safe option as a protocol for infertile patients [21]. There were no differences in clinical pregnancy rates and live birth rates, and the rate of OHSS was lower in the PPOS protocol [21]. PPOS is a viable protocol to prevent a premature LH surge in IVF cycles [22].…”
Section: Prevention Of a Spontaneous Lh Surgementioning
confidence: 99%
“…Use of a moderate dose of long-acting gonadotropin appears to be as effective as daily gonadotropin (Pouwer, et al, 2015) in autologous oocyte cycles; a single injection of Corifollitropin alfa (150-180 mcg) in the first week of stimulation has been shown to increase donor's satisfaction (Requena, et al, 2013). Oral progestogens have been introduced to replace GnRHantagonist injections, both in donor cycles (Begueria, et al, 2019, Martinez, et al, 2019 and in treating infertile couples and have been found to be a more convenient and less expensive method for endogenous LH suppression with equivalent efficacy (Cui, et al, 2021). Although a recent systematic review found a lower incidence of OHSS with progesterone priming, higher requirement of gonadotropin stimulation (Cui, et al, 2021), and a RCT evidence of lower pregnancy rate among the oocyte recipients (Begueria, et al, 2019) cast doubt on the use of progesterone-primed protocols at present (Martinez, et al, 2021).…”
Section: Ovarian Stimulation For Oocyte Donorsmentioning
confidence: 99%