Effectiveness of red alga <i>Asparagopsis taxiformis</i> extracts against <i>Leishmania infantum</i>

Vitale, Fabrizio; Genovese, Giuseppa; Bruno, Federica; Castelli, Germano; Piazza, Maria; Migliazzo, Antonella; Minicante, Simona Armeli; Manghisi, Antonio; Morabito, Marina

doi:10.1515/biol-2015-0050

Cited by 8 publications

(5 citation statements)

References 26 publications

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“…Researchers demonstrated that a concentration of 1 mg/mL of A. armata dichloromethane extracts was able to significantly reduce Human colorectal cancer model (Caco‑2 cells) proliferation, proving antitumoral bioactivity [ 218 ]. For another perspective, A. taxiformis extracts at a concentration of 40 µg/mL exhibited activity against the protozoan Leishmania infantum , which affects animals and humans [ 219 ]. Therefore, this red seaweed extract also demonstrated to be efficient in the inhibition of fungal growth, namely, Aspergillus fumigatus , Aspergillus terreus, and Aspergillus flavus [ 220 ].…”

Section: Pharmacological Potential Of the Invasive Seaweedsmentioning

confidence: 99%

Invasive Seaweeds in the Iberian Peninsula: A Contribution for Food Supply

et al. 2020

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The introduction of exotic organisms in marine ecosystems can lead to economic and ecological losses. Globally, seaweeds represent a significant part of these non-indigenous species (NIS), with 407 introduced algal species. Furthermore, the presence of NIS seaweeds has been reported as a major concern worldwide since the patterns of their potential invasion mechanisms and vectors are not yet fully understood. Currently, in the Iberian Peninsula, around 50 NIS seaweeds have been recorded. Some of these are also considered invasive due to their overgrowth characteristic and competition with other species. However, invasive seaweeds are suitable for industrial applications due to their high feedstock. Hence, seaweeds’ historical use in daily food diet, allied to research findings, showed that macroalgae are a source of nutrients and bioactive compounds with nutraceutical properties. The main goal of this review is to evaluate the records of NIS seaweeds in the Iberian Peninsula and critically analyze the potential of invasive seaweeds application in the food industry.

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Section: Pharmacological Potential Of the Invasive Seaweedsmentioning

confidence: 99%

Invasive Seaweeds in the Iberian Peninsula: A Contribution for Food Supply

et al. 2020

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“…In fact, dichloromethane and hexane extracts from A. taxiformis , ethanol-hexane:ethylacetate and ethanol-ethylacetate fractions from A. taxiformis and A. armata also showed significant effect on L. donovani promastigotes with IC 50 values ranging from 10 to 20 μg/mL [ 52 ]. Additionally, ethanol extract of A. taxiformis was shown to be active against promastigotes and axenic amastigotes of L. infantum with IC 50 values of 25 μg/mL and 9 μg/mL, respectively and acceptable safety profile on VERO and DH82 cell lines (CC 50 > 90 μg/mL) [ 53 ]. These activities of Asparagopsis species could be attributed to the presence of volatile halogenated compounds (halomethanes, haloethers, haloacetals) which have been otherwise described as responsible for the antimicrobial properties of A. armata [ 67 ].…”

Section: Current Status Of Antileishmanial Drug Discovery From Marmentioning

confidence: 99%

Marine Algae as Source of Novel Antileishmanial Drugs: A Review

et al. 2017

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Leishmaniasis is a vector-borne neglected tropical disease caused by protozoan parasites of the Leishmania genus and transmitted by the female Phlebotomus and Lutzomyia sand flies. The currently prescribed therapies still rely on pentavalent antimonials, pentamidine, paromomycin, liposomal amphotericin B, and miltefosine. However, their low efficacy, long-course treatment regimen, high toxicity, adverse side effects, induction of parasite resistance and high cost require the need for better drugs given that antileishmanial vaccines may not be available in the near future. Although most drugs are still derived from terrestrial sources, the interest in marine organisms as a potential source of promising novel bioactive natural agents has increased in recent years. About 28,000 compounds of marine origin have been isolated with hundreds of new chemical entities. Recent trends in drug research from natural resources indicated the high interest of aquatic eukaryotic photosynthetic organisms, marine algae in the search for new chemical entities given their broad spectrum and high bioactivities including antileishmanial potential. This current review describes prepared extracts and compounds from marine macroalgae along with their antileishmanial activity and provides prospective insights for antileishmanial drug discovery.

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“…In the last ten years (Table S1), research has focused on the potential of seaweed extracts in the pharmaceutical field as antimicrobics [154][155][156][157][158][159][160], anticoagulants [161,162] and antidiabetics [64]. In the technological field, biomaterial as bio-oils [163] was obtained from Gracilaria gracilis, whereas chlorophylls from Undaria pinnatifida were tested as dye in photovoltaic cells [164].…”

Section: Research Harvesting and Industrial Activity Of Seaweedsmentioning

confidence: 99%

Bio-Based Products from Mediterranean Seaweeds: Italian Opportunities and Challenges for a Sustainable Blue Economy

Minicante

Bongiorni

2022

Sustainability

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Seaweeds are attracting increasing attention as an alternative healthy food and renewable drugs source and as agents of climate change mitigation that provide essential ecosystem services. In this context, seaweeds represent marine resources capable of supporting and pursuing the objectives of the Sustainable Blue Economy and the Bio-Based Circular Economy. In this review, we analyze the state of seaweed bio-based products and research on the Mediterranean Sea from the last 20 years. Results of this analysis show a large number of investigations focusing on antimicrobial, antioxidant and anti-inflammatory activities compared to on biofuels and bioplastics. Attempts at seaweed farming, although generally very limited, are present in Israel and some North African countries. Lastly, we focus on the Italian situation—including research, companies and legislation on seaweed production—and we discuss gaps, perspectives and challenges for the potential development of a sustainable seaweed industry according to the Sustainable Blue Economy.

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Effectiveness of red alga Asparagopsis taxiformis extracts against Leishmania infantum

Abstract: Leishmaniasis is a disease with a worldwide distribution affecting both humans and animals. There is a need to identify and develop new drugs for the treatment of leishmaniasis. This study showed that crude ethanolic extracts of the red alga

Cited by 8 publications

References 26 publications

Invasive Seaweeds in the Iberian Peninsula: A Contribution for Food Supply

Invasive Seaweeds in the Iberian Peninsula: A Contribution for Food Supply

Marine Algae as Source of Novel Antileishmanial Drugs: A Review

Bio-Based Products from Mediterranean Seaweeds: Italian Opportunities and Challenges for a Sustainable Blue Economy

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