Effectiveness of seasonal influenza vaccination during pregnancy in preventing influenza infection in infants, England, 2013/14

Dabrera, Gavin; Zhao, Hongxin; Andrews, Nicholas; Begum, F; Green, H K; Ellis, Joanna; Elias, K.M.; Donati, Matthew; Zambon, Maria; Pebody, Richard

doi:10.2807/1560-7917.es2014.19.45.20959

Cited by 69 publications

(51 citation statements)

References 11 publications

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“…For subjects younger than 6 months, infant protection from influenza can be assured by maternal vaccination. 67,68 Administration of influenza vaccine is recommended by several health authorities for pregnant women at-risk because suffering from a severe chronic underlying disease. Moreover, considering that influenza can be a disease significantly more severe in pregnant women than in the general population leading in many cases to hospitalization and rarely to death, many health authorities suggest influenza vaccine also to otherwise healthy pregnant women.…”

Section: Influenza Vaccine Administration To Pregnant Womenmentioning

confidence: 99%

Protection of young children from influenza through universal vaccination

Principi

Senatore

Esposito

2015

Human Vaccines & Immunotherapeutics

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Influenza is a very common disease among infants and young children, with a considerable clinical and socioeconomic impact. A significant number of health authorities presently recommend universal influenza vaccination for the pediatric population, but a large number of European health authorities is still reluctant to include influenza vaccination in their national vaccination programs. The reasons for this reluctance include the fact that the protection offered by the currently available vaccines is considered poor. This review shows that although future research could lead to an increase in the immunogenicity and potential efficacy of influenza vaccines, the available vaccines, even with their limits, assure sufficient protection in most subjects aged ≥ 6 months, thus reducing the total burden of influenza in young children and justifying the recommendation for the universal vaccination of the whole pediatric population. For younger subjects, the vaccination of their mother during pregnancy represents an efficacious strategy.

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Section: Influenza Vaccine Administration To Pregnant Womenmentioning

confidence: 99%

Protection of young children from influenza through universal vaccination

Principi

Senatore

Esposito

2015

Human Vaccines & Immunotherapeutics

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show abstract

“…In the US, effectiveness of the vaccine given to pregnant women was 45-92% in preventing seasonal influenza-related hospitalizations in infants aged <6 months [55,56]. In England during the 2013-2014 influenza season, vaccination prevented 71% of influenza infections in infants aged <6 months and 64% of infant hospitalizations due to influenza [57]. Results from a randomized controlled trial in Bangladesh provided a proof of concept that maternal vaccination could reduce infant influenza disease in developing countries, with 36% efficacy against febrile respiratory illness in mothers and 29% in infants and 63% efficacy against confirmed influenza illness in infants, compared to the 23-valent pneumococcal polysaccharide vaccine [58].…”

Section: Influenzamentioning

confidence: 99%

Maternal immunization: where are we now and how to move forward?

et al. 2018

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Pregnancy and the postpartum period are associated with elevated risks to both mother and infant from infectious disease. Vaccination of pregnant women, also called maternal immunization, has the potential to protect pregnant women, foetuses and infants from several vaccinepreventable diseases. Maternal immunoglobulin G antibodies are actively transferred through the placenta to provide passive immunity to new-borns during the first months of life, until the time for infant vaccinations or until the period of greatest susceptibility has passed. Currently, inactivated influenza, tetanus, and pertussis vaccines are recommended during pregnancy in many countries, but other vaccines may also be administered to pregnant women when risk factors are present. Several new vaccines with a specific indication for use during pregnancy are under development (e.g. respiratory syncytial virus and group B streptococcus vaccines). Years of experience suggest that maternal immunization against influenza, tetanus or pertussis has an acceptable safety profile, is well tolerated, effective and confers significant benefits to pregnant women and their infants. This review describes the principles of maternal immunization and provides an update of the recent evidence regarding the use and timing of maternal immunization. Finally, the barriers preventing wider vaccination coverage and the current limitations in addressing these are also described (Supplementary Material). KEY MESSAGESMaternal immunization gives pregnant women greater protection against infectious diseases; induces high levels of maternal antibodies that can be transferred to the foetus; and helps protect new-borns during their first months of life, until they are old enough to be vaccinated. Pregnant women and new-borns are more vulnerable to infectious diseases than the overall population; nevertheless, vaccination rates are often low in pregnant women. This review provides an update of the recent evidence regarding the use and timing of maternal immunization and describes the barriers preventing wider vaccination uptake and the current limitations in addressing these. ARTICLE HISTORY

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“…[73][74][75] Vaccine effectiveness in the studies that used a laboratory confirmed end point ranged from 48% to 91.5%. 73,74 These demonstrate the importance of the vaccine in reducing severe disease and hospitalization in children too young to be vaccinated.…”

Section: Maternal Influenza Immunization For Infantsmentioning

confidence: 99%

Vaccines in pregnancy: The dual benefit for pregnant women and infants

Marshall

McMillan

Andrews

et al. 2016

Human Vaccines & Immunotherapeutics

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Maternal immunization has the potential to reduce the burden of infectious diseases in the pregnant woman and her infant. Many countries now recommend immunization against influenza at any stage of pregnancy and against pertussis in the third trimester. Despite evidence of the safety and effectiveness of these vaccines when administered during pregnancy, uptake generally remains low for influenza and moderate for pertussis vaccine. Enhancing confidence in both immunization providers and pregnant women by increasing the evidence-base for the safety and effectiveness of vaccines during pregnancy, improving communication and access by incorporating immunization into standard models of antenatal care are likely to improve uptake. Developing a framework for implementation of vaccines for pregnant women which is cognizant of local and national cultural, epidemiological, behavioral and societal factors will enable a smooth transition and high uptake for new vaccines currently in development for pregnant women.

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Effectiveness of seasonal influenza vaccination during pregnancy in preventing influenza infection in infants, England, 2013/14

Abstract: Binary file ES_Abstracts_Final_ECDC.txt matches

Cited by 69 publications

References 11 publications

Protection of young children from influenza through universal vaccination

Protection of young children from influenza through universal vaccination

Maternal immunization: where are we now and how to move forward?

Vaccines in pregnancy: The dual benefit for pregnant women and infants

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