2008
DOI: 10.1111/j.1469-8749.2008.03069.x
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Effectiveness of sedation using nitrous oxide compared with enteral midazolam for botulinum toxin A injections in children

Abstract: This randomized, double-blind, placebo-controlled study compared the efficacy of inhaled nitrous oxide (N 2 O) with enteral midazolam for sedation of children with cerebral palsy (CP) undergoing botulinum toxin A (BoNT-A) injections. Fifty children (29 males, 21 females; mean age 8y 2mo [SD 4y 5mo]; range 1-16y) were randomized to sedation with N 2 O (n=25) or midazolam (n=25). Groups were similar in type of

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Cited by 42 publications
(22 citation statements)
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“…Furthermore, inhalation of nitrous oxide at 50%, prior to intravenous administration of propofol, reduces the pain associated with injection in children, when compared to the inhalation of 100% oxygen 60 (A). In children with cerebral palsy submitted to injection of botulinum toxin A, sedation promoted by the inhalation of nitrous oxide is more effective than midazolam administered by the enteral route 61 …”
Section: Injectionsmentioning
confidence: 98%
See 1 more Smart Citation
“…Furthermore, inhalation of nitrous oxide at 50%, prior to intravenous administration of propofol, reduces the pain associated with injection in children, when compared to the inhalation of 100% oxygen 60 (A). In children with cerebral palsy submitted to injection of botulinum toxin A, sedation promoted by the inhalation of nitrous oxide is more effective than midazolam administered by the enteral route 61 …”
Section: Injectionsmentioning
confidence: 98%
“…Recommendation: The administration of nitrous oxide, alone or in combination with EMLA is associated with effective sedation and pain relief in children receiving injections [59][60][61] (A).…”
Section: (A)mentioning
confidence: 99%
“…Zier et al 22 Randomized, double-blind and placebo controlled: 50 children randomized in two groups (nitrous oxide and midazolam citrate) aged between one and 16 years.…”
Section: Acute Pain Managementmentioning
confidence: 99%
“…The postoperative period becomes more complicated for these children, especially for those unable to verbally communicate, being important the qualification of professionals for the adequate assistance of this population [17][18][19][20][21][22][23][24][25][26] . It was also observed the importance of the anesthetic process in the perioperative period of children submitted to botulinum toxin injections since this procedure requires several muscle punctures and is referred as painful.…”
Section: Riquelme and Montoya 30mentioning
confidence: 99%
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