Effectiveness of self-financed rotavirus vaccination in Ise City, Japan

Ito, Mitsue; Higashigawa, Masamune

doi:10.1080/21645515.2021.1972706

Cited by 4 publications

(4 citation statements)

References 20 publications

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“…Rotavirus vaccines produce a herd immunity effect and reduce hospitalization from rotavirus gastroenteritis. [32][33][34] In Japan, rotavirus vaccines have been commercially available since 2011 for voluntary vaccination, and vaccine coverage increased from 30.0% in 2012 to 78.4% in 2019, though full coverage has not been reached. 35 In October 2020, the rotavirus vaccine became available for routine vaccination in Japan, 36 and the vaccine coverage is expected to reach >95%, which is the coverage level for other routine vaccines.…”

Section: Discussionmentioning

confidence: 99%

Changing Patterns of Infectious Diseases Among Hospitalized Children in Hokkaido, Japan, in the Post-COVID-19 Era, July 2019 to June 2022

Fukuda

Togashi

Hirakawa

et al. 2023

Pediatric Infectious Disease Journal

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Background: Many reports have reported a reduction in respiratory infectious diseases and infectious gastroenteritis immediately after the coronavirus disease 2019 (COVID-19) pandemic, but data continuing into 2022 are very limited. We sought to understand the current situation of various infectious diseases among children in Japan as of July 2022 to improve public health in the post-COVID-19 era. Methods: We collected data on children hospitalized with infectious diseases in 18 hospitals in Japan from July 2019 to June 2022. Results: In total, 3417 patients were hospitalized during the study period. Respiratory syncytial virus decreased drastically after COVID-19 spread in early 2020, and few patients were hospitalized for it from April 2020 to March 2021. However, an unexpected out-of-season re-emergence of respiratory syncytial virus was observed in August 2021 (50 patients per week), particularly prominent among older children 3–6 years old. A large epidemic of delayed norovirus gastroenteritis was observed in April 2021, suggesting that the nonpharmaceutical interventions for COVID-19 are less effective against norovirus. However, influenza, human metapneumovirus, Mycoplasma pneumoniae, and rotavirus gastroenteritis were rarely seen for more than 2 years. Conclusions: The incidence patterns of various infectious diseases in Japan have changed markedly since the beginning of the COVID-19 pandemic to the present. The epidemic pattern in the post-COVID-19 era is unpredictable and will require continued careful surveillance.

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Section: Discussionmentioning

confidence: 99%

Changing Patterns of Infectious Diseases Among Hospitalized Children in Hokkaido, Japan, in the Post-COVID-19 Era, July 2019 to June 2022

Fukuda

Togashi

Hirakawa

et al. 2023

Pediatric Infectious Disease Journal

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“…The inconsistent results regarding hospitalisation for diarrhoea between the 2001 and 2010 cohorts may be attributed to the start of optional rotavirus vaccinations in Japan in 2011. Although participants in the present study were not eligible for vaccination, a reduction in hospitalisation for rotavirus enterocolitis and herd immunity effects in unvaccinated children were reported 19,20 . This decrease in the overall hospitalisation rate for enterocolitis may have influenced the current results.…”

Section: Discussionmentioning

confidence: 68%

“…Although participants in the present study were not eligible for vaccination, a reduction in hospitalisation for rotavirus enterocolitis and herd immunity effects in unvaccinated children were reported. 19,20 This decrease in the overall hospitalisation rate for enterocolitis may have influenced the current results.…”

Section: F I G U R E 1 Study Flow Chartmentioning

confidence: 91%

A nationwide birth cohort in Japan showed increased risk of early childhood hospitalisation in infants born small for gestational age

Ohyama,

Matsumoto,

Tamai

et al. 2023

Acta Paediatrica

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AimTo examine associations between children being born small for gestational age and childhood hospitalisation following term and preterm births.MethodsThis study included 34 564 children from a nationwide population‐based longitudinal survey starting in 2010, comprising 32 603 term births and 1961 preterm births. Children's hospitalisation history was examined during two observational periods, 6–18 and 6–66 months of age. Logistic regression analysis was conducted, adjusting for child and parental confounders, with children born appropriate for gestational age as reference.ResultsChildren born small for gestational age were more likely to be hospitalised during early childhood than those born appropriate for gestational age. The odds ratio (95% confidence interval) for hospitalisation from 6 to 66 months of age was 1.19 (1.05–1.34) in term children born small for gestational age and 1.47 (1.05–2.06) for preterm children born small for gestational age, compared with those born appropriate for gestational age. The risk of hospitalisation from 6 to 66 months of age in children born small for gestational age was observed for bronchitis/pneumonia.ConclusionWe observed the adverse effects of small for gestational age on hospitalisation during early childhood in both term and preterm births, particularly for bronchitis and pneumonia.

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“…Further studies are needed to clarify the differences in the quality of cross-reactivity among immune responses acquired by vaccination and natural infection with wild strains. While previous studies have elucidated upon the development of herd immunity induced by RNA vaccines ( Paulke-Korinek et al, 2011 ; Mast et al, 2015 ; Ito and Higashigawa, 2021 ), the G12 strain continued to be predominant in the United States even after vaccine introduction. It has been suggested that one reason may be due to a lower level of vaccine efficacy against G12 strains (i.e., different VP7 genotypes) ( Esona et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Molecular evolutionary analysis of novel NSP4 mono-reassortant G1P[8]-E2 rotavirus strains that caused a discontinuous epidemic in Japan in 2015 and 2018

Fujii,

Tsugawa,

Fukuda

et al. 2024

Front. Microbiol.

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In the 2010s, several unusual rotavirus strains emerged, causing epidemics worldwide. This study reports a comprehensive molecular epidemiological study of rotaviruses in Japan based on full-genome analysis. From 2014 to 2019, a total of 489 rotavirus-positive stool specimens were identified, and the associated viral genomes were analyzed by next-generation sequencing. The genotype constellations of those strains were classified into nine patterns (G1P[8] (Wa), G1P[8]-E2, G1P[8] (DS-1), G2P[4] (DS-1), G3P[8] (Wa), G3P[8] (DS-1), G8P[8] (DS-1), G9P[8] (Wa), and G9P[8]-E2). The major prevalent genotype differed by year, comprising G8P[8] (DS-1) (37% of that year’s isolates) in 2014, G1P[8] (DS-1) (65%) in 2015, G9P[8] (Wa) (72%) in 2016, G3P[8] (DS-1) (66%) in 2017, G1P[8]-E2 (53%) in 2018, and G9P[8] (Wa) (26%) in 2019. The G1P[8]-E2 strains (G1-P[8]-I1-R1-C1-M1-A1-N1-T1-E2-H1) isolated from a total of 42 specimens in discontinuous years (2015 and 2018), which were the newly-emerged NSP4 mono-reassortant strains. Based on the results of the Bayesian evolutionary analyses, G1P[8]-E2 and G9P[8]-E2 were hypothesized to have been generated from distinct independent inter-genogroup reassortment events. The G1 strains detected in this study were classified into multiple clusters, depending on the year of detection. A comparison of the predicted amino acid sequences of the VP7 epitopes revealed that the G1 strains detected in different years encoded VP7 epitopes harboring distinct mutations. These mutations may be responsible for immune escape and annual changes in the prevalent strains.

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Effectiveness of self-financed rotavirus vaccination in Ise City, Japan

Cited by 4 publications

References 20 publications

Changing Patterns of Infectious Diseases Among Hospitalized Children in Hokkaido, Japan, in the Post-COVID-19 Era, July 2019 to June 2022

Changing Patterns of Infectious Diseases Among Hospitalized Children in Hokkaido, Japan, in the Post-COVID-19 Era, July 2019 to June 2022

A nationwide birth cohort in Japan showed increased risk of early childhood hospitalisation in infants born small for gestational age

Molecular evolutionary analysis of novel NSP4 mono-reassortant G1P[8]-E2 rotavirus strains that caused a discontinuous epidemic in Japan in 2015 and 2018

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