Effectiveness of Serotonin-Receptor Antagonist Antiemetic Therapy over Successive Courses of Carboplatin-Based Chemotherapy

Markman, M.; Peterson, Gertrude; Kulp, Barbara; Markman, Maurie

doi:10.1006/gyno.2002.6656

Cited by 4 publications

(2 citation statements)

References 13 publications

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“…A decline in antiemetic effect has been shown during successive treatment cycles with standard antiemetic regimens, including high-dose metoclopramide plus dexamethasone or methylprednisolone [74] and combination prophylaxis with methylprednisolone, thiethylperazine, and amitriptyline [75]. In contrast, combination therapy with a 5-HT 3 -receptor antagonist plus dexamethasone has been shown to be effective in the majority of patients over successive courses of carboplatin-based chemotherapy [76]. Unlike metoclopramide, antiemetic efficacy of ondansetron plus dexamethasone was retained in patients who completed second and third cycles of cisplatin chemotherapy [27].…”

Section: Multiple-cycle Chemotherapymentioning

confidence: 99%

Chemotherapy-Induced Nausea and Vomiting: The Importance of Acute Antiemetic Control

Schnell¹

2003

The Oncologist

189

167

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Nausea and vomiting are two of the most feared side effects of cancer chemotherapy and radiotherapy. Chemotherapy-induced nausea and vomiting can be broadly categorized as acute (occurring within 24 hours of therapy), delayed (persisting for 6-7 days after therapy), or anticipatory (occurring prior to chemotherapy administration). Breakthrough and refractory nausea and vomiting describe the symptoms of uncontrolled emesis. Evidence suggests that good control of nausea and vomiting during the acute period correlates with the control of delayed emesis. Conversely, protection failure during the first 24 hours has a high predictive value for delayed emesis in the same cycle.The 5-HT 3 -receptor antagonists, regarded as the 'gold standard' in antiemetic therapy, are the first-line treatment for moderately and highly emetogenic chemotherapy and radiotherapy regimens in adults and children. Evidence suggests that the 5-HT 3 -receptor antagonists administered in combination with corticosteroids afford the best protection from symptoms of acute emesis and, by extrapolation, the most effective prevention of delayed emesis.Antiemetic therapeutic guidelines stress that the goal of therapy is to prevent cytostatic-induced nausea and vomiting. Therefore, the prophylactic use of the most effective antiemetic regimen-taking into consideration the emetogenicity of the chemotherapy and individual patient characteristics-must be adhered to in order to prevent acute, delayed, and anticipatory nausea and vomiting.

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Section: Multiple-cycle Chemotherapymentioning

confidence: 99%

Chemotherapy-Induced Nausea and Vomiting: The Importance of Acute Antiemetic Control

Schnell¹

2003

The Oncologist

189

167

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“…Серотонін (5гидрокситриптамін або 5-НТ) утворюється з незамінної амінокислоти триптофану і в найвищих концентраціях міститься в ентерохромафінних клітинах слизової оболонки тонкої кишки (до 90% всього серотоніну в організмі). Серотонін звільняється при цитостатичному ушкодженні слизової травного тракту, зв'язується з 5-НТ3-рецепторами блукаючого нерва, які активують блювотний центр, або безпосередньо активують 5-НТ3-рецептори стовбура мозку, викликаючи блювання [9,11].…”

Section: вступunclassified

Correction of the Emetic Syndrome in Case of the Chemotherapy

Borysenko

Maikut-Zabrodskaja

Melnyk

et al. 2019

gec

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Current Awareness: Pharmacoepidemiology and Drug Safety

2002

Pharmacoepidemiology and Drug

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of pharmacoepidemiology and drug safety. Each bibliography is divided into 19 sections: 1 Books, Reviews & Symposia; 2 General; 3 Anti‐infective Agents; 4 Cardiovascular System Agents; 5 CNS Depressive Agents; 6 Non‐steroidal Anti‐inflammatory Agents; 7 CNS Agents; 8 Anti‐neoplastic Agents; 9 Haematological Agents; 10 Neuroregulator‐Blocking Agents; 11 Dermatological Agents; 12 Immunosuppressive Agents; 13 Autonomic Agents; 14 Respiratory System Agents; 15 Neuromuscular Agents; 16 Reproductive System Agents; 17 Gastrointestinal System Agents; 18 Anti‐inflammatory Agents ‐ Steroidal; 19 Others. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted.

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Effectiveness of Serotonin-Receptor Antagonist Antiemetic Therapy over Successive Courses of Carboplatin-Based Chemotherapy

Cited by 4 publications

References 13 publications

Chemotherapy-Induced Nausea and Vomiting: The Importance of Acute Antiemetic Control

Chemotherapy-Induced Nausea and Vomiting: The Importance of Acute Antiemetic Control

Correction of the Emetic Syndrome in Case of the Chemotherapy

Current Awareness: Pharmacoepidemiology and Drug Safety

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