Background: Postpartum period is highly critical, as mothers are vulnerable to hazards and most of sudden emergency and life threatening complications occurs during this period. If the mothers received an effective care, their mortality and complications will be reduced. So, mother's knowledge and education before childbirth regarding postpartum complications and ways of its preventions are important. Aim of the study: Focused to evaluate the effect of antenatal educational package on primiparous women's knowledge and practices for prevention of selected aspects postpartum complications. Research design: A quasi experimental design was used. Setting: On antenatal and postnatal departments at Zagazig University hospitals. Subjects: A purposive sample composed of 100 primiparous women divided into two groups (intervention and control). Tools of data collections: Three tools were used as: Tool I: Interviewing questionnaire. Tool II: Self-structured knowledge questionnaire and Tool III: An observational checklist regarding selected practices to prevent some of postpartum complications. Results: It was observed that after applying the educational package there was a highly statistically significant difference between the means of total score of knowledge and practice in intervention group than those in control one throughout the study phases. Moreover, the control group had a high percentage of postpartum complications than the intervention group with no statistical difference. Conclusion: It was evident that the educational package was effective in enhancing knowledge and practice where, the intervention group had higher score than the control, also had a significant reduction in the occurrences of postpartum complications than those in the control. Recommendations: It is mandatory to establish a comprehensive training intervention for primiparous pregnant women at MCH centers to enhance their knowledge and practices on postpartum complications and methods of preventions which can reduce the maternal morbidity and complications.